ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2017
White Matter Microstructural Alterations in Children with ADHD: Categorical and Dimensional Perspectives.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 4 syntheses or guidelines pooled it, 81 citations in OpenAlex.
- White matter alterations in Attention-Deficit/Hyperactivity Disorder (ADHD): a systematic review of 129 diffusion imaging studies with meta-analysis.Molecular psychiatry · 2023Pooled it
- White matter microstructure in children and adolescents with ADHD.NeuroImage. Clinical · 2022Pooled it
- Genetic Markers of ADHD-Related Variations in Intracranial Volume.The American journal of psychiatry · 2019Pooled it
- Brain imaging genetics in ADHD and beyond - Mapping pathways from gene to disorder at different levels of complexity.Neuroscience and biobehavioral reviews · 2017Pooled it
- The cingulum as a marker of individual differences in neurocognitive development.Scientific reports · 2019Trial
- Dissecting the shared genetic architecture between testosterone traits and attention-deficit/hyperactivity disorder.European child & adolescent psychiatry · 2026Article
- Structural integrity of the anterior thalamic radiation predicts alpha oscillations and inattention during visual encoding.Scientific reports · 2026Article
- ADHD symptoms and efficient learning strategies in college students: the parallel mediating roles of motivation and mind-wandering.Frontiers in psychology · 2026Article
- Deep adversarial learning identifies ADHD-specific associations between apoptotic genes and white matter microstructure in frontal-striatum-cerebellum circuit.Translational psychiatry · 2025Article
- Spine-Prints: Transposing Brain Fingerprints to the Spinal Cord.bioRxiv : the preprint server for biology · 2025Article
- Quantification of myelination in children with attention-deficit/hyperactivity disorder: a comparative assessment with synthetic MRI and DTI.European child & adolescent psychiatry · 2024Article
- Association between reported ADHD symptom and motor development delay in preschool children.Frontiers in pediatrics · 2024Article
- Brain Function Characteristics of Children with Attention-Deficit/Hyperactivity Disorder Aged 4-9 Years During a GO/NOGO Task: An Functional Near-Infrared Spectroscopy Study.Neuropsychiatric disease and treatment · 2024Article
- Review
- Adolescents with ADHD and co-occurring motor difficulties show a distinct pattern of maturation within the corticospinal tract from those without: A longitudinal fixel-based study.Human brain mapping · 2023Article
- Functional and structural brain network development in children with attention deficit hyperactivity disorder.Human brain mapping · 2023Article
- Multivariate associations between behavioural dimensions and white matter across children and adolescents with and without attention-deficit/hyperactivity disorder.Journal of child psychology and psychiatry, and allied disciplines · 2023Article
- The clinical, neuropsychological, and brain functional characteristics of the ADHD restrictive inattentive presentation.Frontiers in psychiatry · 2023Article
- DUSP15 expression is reduced in the hippocampus of Myrf knock-out mice but attention and object recognition memory remain intact.PloS one · 2023Article
- Attention-deficit/hyperactivity disorder and white matter microstructure: the importance of dimensional analyses and sex differences.JCPP advances · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Studies of brain alterations in children with attention-deficit/hyperactivity disorder (ADHD) have shown heterogeneous results. The aims of the current study were to investigate white matter microstructure in children using both categorical and dimensional definitions of ADHD and to determine the functional consequences of observed alterations. In a large single-site sample of children (aged 8-15 years) with ADHD (n=83) and healthy controls (n=122), we used tract-based spatial statistics on diffusion tensor imaging data to investigate whole-skeleton differences of fractional anisotropy (FA), mean, axial, and radial diffusivity (MD, AD, RD), and mode of anisotropy related to ADHD status (categorical) and symptom severity (dimensional). For categorical differences observed, we analyzed their association with cognitive functioning in working memory and inhibition. Compared with healthy controls, children with ADHD showed decreased FA and increased RD in widespread, overlapping brain regions, mainly in corpus callosum (CC) and major tracts in the left hemisphere. Decreased FA was associated with inhibition performance in the participants with ADHD. Using dimensional definitions, greater hyperactivity/impulsivity symptom severity was associated with higher FA also in widespread regions, mainly in CC and major tracts in the right hemisphere. Our study showed white matter alterations to be related to ADHD status and symptom severity in patients. The coexistence of decreased FA and increased RD in the absence of alterations in MD or AD might indicate altered myelination as a pathophysiological factor in ADHD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.