Evidence map›Paper›PMID 27681204›Full record

ReviewInternational wound journal2017

Deconstructing negative pressure wound therapy.

Shadi Lalezari, Christine J Lee, Anna A Borovikova, Derek A Banyard, Keyianoosh Z Paydar, Garrett A Wirth, Alan D Widgerow

Registry-linked trialOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International wound journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05169814 (Micro/Nanobubbles), which is not on this map. Cited by 44 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 1 pooled it
5.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05169814 early_phase1recruitingnot on this mapstarted 2021, after this paper: background citation

Micro/Nanobubbles (MNBs) and Wound Therapy: A Pilot Study Involving a Novel Oxygen Delivery System for Treatment of Acute and Chronic Wounds

TypeinterventionalSponsorUniversity of California, IrvineRan2021 to 2027Enrolled40ConditionsOpen Wound, Wound HealArmsMicro/nanobubble (MNB) - Irrigation, 0.9% Normal Saline - Irrigation, Micro/nanobubble (MNB) - Negative Pressure Wound Therapy with Instillation (NPWTi), 0.9% Normal Saline - Negative Pressure Wound Therapy with Instillation (NPWTi)
3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 1 synthesis or guideline pooled it, 118 citations in OpenAlex.

  1. Skin graft bolstered by negative pressure therapy in chronic wounds: A systematic review.Journal of the European Academy of Dermatology and Venereology : JEADV · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Shadi LalezariCenter for Tissue Engineering, Department of Plastic Surgery, University of California, Irvine, CA, USA.
Christine J LeeCenter for Tissue Engineering, Department of Plastic Surgery, University of California, Irvine, CA, USA.
Anna A BorovikovaCenter for Tissue Engineering, Department of Plastic Surgery, University of California, Irvine, CA, USA.
Derek A BanyardCenter for Tissue Engineering, Department of Plastic Surgery, University of California, Irvine, CA, USA.
Keyianoosh Z PaydarCenter for Tissue Engineering, Department of Plastic Surgery, University of California, Irvine, CA, USA.
Garrett A WirthCenter for Tissue Engineering, Department of Plastic Surgery, University of California, Irvine, CA, USA.
Alan D WidgerowCenter for Tissue Engineering, Department of Plastic Surgery, University of California, Irvine, CA, USA.
University of California, Irvine · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Since its introduction 20 years ago for the treatment of chronic wounds, negative pressure wound therapy use has expanded to a variety of other wound types. Various mechanisms of action for its efficacy in wound healing have been postulated, but no unifying theory exists. Proposed mechanisms include induction of perfusion changes, microdeformation, macrodeformation, exudate control and decreasing the bacterial load in the wound. We surmise that these different mechanisms have varying levels of dominance in each wound type. Specifically, negative pressure wound therapy is beneficial to acute open wounds because it induces perfusion changes and formation of granulation tissue. Post-surgical incisional wounds are positively affected by perfusion changes and exudate control. In the context of chronic wounds, negative pressure wound therapy removes harmful and corrosive substances within the wounds to affect healing. When skin grafts and dermal substitutes are used to close a wound, negative pressure wound therapy is effective in promoting granulation tissue formation, controlling exudate and decreasing the bacterial load in the wound. In this review, we elucidate some of the mechanisms behind the positive wound healing effects of negative pressure wound therapy, providing possible explanations for these effects in different wound types.

Indexed as

AdultAgedAged, 80 and overChronic DiseaseFemaleHumansMaleMiddle AgedNegative-Pressure Wound TherapyWound HealingWounds and InjuriesExudate controlMacrodeformationMicrodeformationNegative pressure wound therapyPerfusion changes

Identifiers

PMID27681204
PMCPMC7949947
OpenAlexW2528395763

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.