Evidence map›Paper›PMID 27681179›Full record

ArticleAmerican journal of physiology. Cell physiology2016

Mouse Slc4a11 expressed in Xenopus oocytes is an ideally selective H+/OH- conductance pathway that is stimulated by rises in intracellular and extracellular pH.

Evan J Myers, Aniko Marshall, Michael L Jennings, Mark D Parker

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Cell physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
6.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 44 citations in OpenAlex.

  1. Trial
  2. Biomolecules · 2025
    Review
  3. Systematic review:Frontiers in medicine · 2025
    Review
  4. The role of NaPflugers Archiv : European journal of physiology · 2024
    Review
  5. NHFrontiers in physiology · 2024
    Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. The HCells · 2022
    Review
  14. Article
  15. Article
  16. Altered gene expression in slc4a11Scientific reports · 2021
    Article
  17. "SLC-omics" of the kidney: solute transporters along the nephron.American journal of physiology. Cell physiology · 2021
    Review
  18. The therapeutic importance of acid-base balance.Biochemical pharmacology · 2021
    Review
  19. pH dependence of the Slc4a11-mediated HAmerican journal of physiology. Cell physiology · 2020
    Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Evan J MyersDepartment of Physiology and Biophysics, The State University of New York: The University at Buffalo, Buffalo, New York.
Aniko MarshallDepartment of Physiology and Biophysics, The State University of New York: The University at Buffalo, Buffalo, New York.
Michael L JenningsDepartment of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas.
Mark D ParkerDepartment of Physiology and Biophysics, The State University of New York: The University at Buffalo, Buffalo, New York; parker28@buffalo.edu.
University at Buffalo, State University of New York · USUniversity of Arkansas for Medical Sciences · US

Funding

Functional role of transporter Slc4a11 (BTR1/NaBC1) in the corneaR21EY021646 · NEI · UNIV OF ARKANSAS FOR MED SCIS · PI JENNINGS, MICHAEL L, PARKER, MARK · 2012 to 2013
$416k
NEI NIH HHS R21 EY021646
6 · The paper itself

Abstract

The SLC4A11 gene encodes the bicarbonate-transporter-related protein BTR1, which is mutated in syndromes characterized by vision and hearing loss. Signs of these diseases [congenital hereditary endothelial dystrophy (CHED) and Harboyan syndrome] are evident in mouse models of Slc4a11 disruption. However, the intrinsic activity of Slc4a11 remains controversial, complicating assignment of its (patho)physiological role. Most studies concur that Slc4a11 transports H

Indexed as

AnimalsAnion Transport ProteinsAntiportersBicarbonatesCorneal Dystrophies, HereditaryCytoplasmHearing Loss, SensorineuralHydrogen-Ion ConcentrationHydroxidesMembrane PotentialsMiceOocytesSodiumSymportersXenopusAnion Transport ProteinsAntiportersBicarbonateshydroxide ionHydroxidesSlc4a11 protein, mouseSodiumSymportersacid-basecorneafluid transportNaBC1proton

Identifiers

PMID27681179
PMCPMC5206308
OpenAlexW2526425776

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.