ArticleInternational journal of epidemiology2016
Relationship between mediation analysis and the structured life course approach.
Article in International journal of epidemiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- What Increases the Likelihood of Dementia Among Asian Americans? Analysis of Nativity and Life Course Factors.Journal of racial and ethnic health disparities · 2026Article
- Life-course Psychosocial Adversity and Biological Aging in the Hispanic Community Health Study / Study of Latinos: A Life-course Model Analysis.Research square · 2026Article
- Life course adversity and risk of incident atrial fibrillation: causal mediation analysis of psychological distress in the population-based Tromsø Study.BMJ public health · 2026Article
- Article
- Geographic Access Barrier as a Critical Mediator in Obstetric Fistula Treatment Cascade in Nigeria: Evidence from a Causal Mediation Analysis of 5,496 Cases.International journal of women's health · 2026Article
- Association of childhood and adult socioeconomic status with adult social connection: a mediation analysis.American journal of epidemiology · 2025Article
- Intergenerational transmission of health inequalities: research agenda for a life course approach to socioeconomic inequalities in health.Journal of epidemiology and community health · 2024Article
- Intra-generational social mobility and mortality among older men in the Concord Health and Ageing in Men Project: A cohort study.SSM - population health · 2024Article
- Intergenerational educational trajectories and inequalities in longevity: A population-based study of adults born before 1965 in 14 European countries.SSM - population health · 2023Article
- Incorporating interactions into structured life course modelling approaches: A simulation study and applied example of the role of access to green space and socioeconomic position on cardiometabolic health.medRxiv : the preprint server for health sciences · 2023Article
- Intergenerational educational trajectories and premature mortality from chronic diseases: A registry population-based study.SSM - population health · 2022Article
- Cardiovascular health in the menopause transition: a longitudinal study of up to 3892 women with up to four repeated measures of risk factors.BMC medicine · 2022Article
- Urinary sodium excretion and the risk of CVD: a community-based cohort study in Taiwan.The British journal of nutrition · 2022Article
- Associations between indicators of socioeconomic position and DNA methylation: a scoping review.Clinical epigenetics · 2021Article
- Passive Smoking Throughout the Life Course and the Risk of Incident Rheumatoid Arthritis in Adulthood Among Women.Arthritis & rheumatology (Hoboken, N.J.) · 2021Article
- A Structured Approach to Evaluating Life-Course Hypotheses: Moving Beyond Analyses of Exposed Versus Unexposed in the -Omics Context.American journal of epidemiology · 2021Article
- Association of the Mediterranean Diet With Onset of Diabetes in the Women's Health Study.JAMA network open · 2020Article
- Stress resilience in young men mediates the effect of childhood trauma on their offspring's birth weight - An analysis of 250,000 families.SSM - population health · 2019Article
- Association between antenatal blood pressure and 5-year postpartum retinal arteriolar structural and functional changes.BMJ open ophthalmology · 2019Article
- A Bayesian approach to investigate life course hypotheses involving continuous exposures.International journal of epidemiology · 2018Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Many questions in life course epidemiology involve mediation and/or interaction because of the long latency period between exposures and outcomes. In this paper, we explore how mediation analysis (based on counterfactual theory and implemented using conventional regression approaches) links with a structured approach to selecting life course hypotheses. Using theory and simulated data, we show how the alternative life course hypotheses assessed in the structured life course approach correspond to different combinations of mediation and interaction parameters. For example, an early life critical period model corresponds to a direct effect of the early life exposure, but no indirect effect via the mediator and no interaction between the early life exposure and the mediator. We also compare these methods using an illustrative real-data example using data on parental occupational social class (early life exposure), own adult occupational social class (mediator) and physical capability (outcome).
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