Evidence map›Paper›PMID 27680877›Full record

Trial reportThe Journal of clinical endocrinology and metabolism2016

Nuchal Skinfold Thickness: A Novel Parameter for Assessment of Body Composition in Childhood Craniopharyngioma.

Anthe S Sterkenburg, Anika Hoffmann, Julia Reichel, Kristin Lohle, Maria Eveslage, Monika Warmuth-Metz, Hermann L Müller

Open access · hybridAbstract readClinical TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of clinical endocrinology and metabolism, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Anthe S SterkenburgDepartment of Pediatrics (A.S.S., A.H., J.R., K.L., H.L.M.), Klinikum Oldenburg AöR, Medical Campus University Oldenburg, 26133 Oldenburg, Germany; University of Groningen (A.S.S.), 9700 Groningen, The Netherlands; Institute of Biostatistics and Clinical Research (M.E.), University of Münster, 48149 Münster, Germany; and Department of Neuroradiology (M.W.-M.), University Hospital, 97080 Würzburg, Germany.
Anika HoffmannDepartment of Pediatrics (A.S.S., A.H., J.R., K.L., H.L.M.), Klinikum Oldenburg AöR, Medical Campus University Oldenburg, 26133 Oldenburg, Germany; University of Groningen (A.S.S.), 9700 Groningen, The Netherlands; Institute of Biostatistics and Clinical Research (M.E.), University of Münster, 48149 Münster, Germany; and Department of Neuroradiology (M.W.-M.), University Hospital, 97080 Würzburg, Germany.
Julia ReichelDepartment of Pediatrics (A.S.S., A.H., J.R., K.L., H.L.M.), Klinikum Oldenburg AöR, Medical Campus University Oldenburg, 26133 Oldenburg, Germany; University of Groningen (A.S.S.), 9700 Groningen, The Netherlands; Institute of Biostatistics and Clinical Research (M.E.), University of Münster, 48149 Münster, Germany; and Department of Neuroradiology (M.W.-M.), University Hospital, 97080 Würzburg, Germany.
Kristin LohleDepartment of Pediatrics (A.S.S., A.H., J.R., K.L., H.L.M.), Klinikum Oldenburg AöR, Medical Campus University Oldenburg, 26133 Oldenburg, Germany; University of Groningen (A.S.S.), 9700 Groningen, The Netherlands; Institute of Biostatistics and Clinical Research (M.E.), University of Münster, 48149 Münster, Germany; and Department of Neuroradiology (M.W.-M.), University Hospital, 97080 Würzburg, Germany.
Maria EveslageDepartment of Pediatrics (A.S.S., A.H., J.R., K.L., H.L.M.), Klinikum Oldenburg AöR, Medical Campus University Oldenburg, 26133 Oldenburg, Germany; University of Groningen (A.S.S.), 9700 Groningen, The Netherlands; Institute of Biostatistics and Clinical Research (M.E.), University of Münster, 48149 Münster, Germany; and Department of Neuroradiology (M.W.-M.), University Hospital, 97080 Würzburg, Germany.
Monika Warmuth-MetzDepartment of Pediatrics (A.S.S., A.H., J.R., K.L., H.L.M.), Klinikum Oldenburg AöR, Medical Campus University Oldenburg, 26133 Oldenburg, Germany; University of Groningen (A.S.S.), 9700 Groningen, The Netherlands; Institute of Biostatistics and Clinical Research (M.E.), University of Münster, 48149 Münster, Germany; and Department of Neuroradiology (M.W.-M.), University Hospital, 97080 Würzburg, Germany.
Hermann L MüllerDepartment of Pediatrics (A.S.S., A.H., J.R., K.L., H.L.M.), Klinikum Oldenburg AöR, Medical Campus University Oldenburg, 26133 Oldenburg, Germany; University of Groningen (A.S.S.), 9700 Groningen, The Netherlands; Institute of Biostatistics and Clinical Research (M.E.), University of Münster, 48149 Münster, Germany; and Department of Neuroradiology (M.W.-M.), University Hospital, 97080 Würzburg, Germany.
Klinikum Oldenburg · DEUniversitätsklinikum Würzburg · DEUniversity of Groningen · NLUniversity of Münster · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

contextHypothalamic obesity, cardiovascular disease (CVD), and relapse/progression have a major impact on prognosis in childhood-onset craniopharyngioma (CP). We analyzed nuchal skinfold thickness (NST) on magnetic resonance imaging performed for follow-up monitoring as a novel parameter for body composition (BC) and CVD in CP.

objectiveThe objective of the study was to identify the association of NST with body mass index (BMI), waist to height ratio (WHtR), functional capacity, and blood pressure (BP) in CP and controls.

designThis was a cross-sectional and longitudinal prospective study in CP patients.

settingThe study was conducted at HIT-Endo, KRANIOPHARYNGEOM 2000/2007. PATIENTS: Participants included 94 CP patients and 75 controls.

interventionsThere were no interventions.

main outcome measuresAssociation of NST with BC and BP in 43 CP and 43 controls was measured.

resultsNST correlated with BMI SD score (SDS; r = 0.78; P < .001; n = 169) and WHtR (r = 0.85; P < .001; n = 86) in the total cohort and CP patients (NST-BMI SDS: r = 0.77, P < .001, n = 94); NST-WHtR: r = 0.835, P < .001, n=43) and controls (NST-BMI SDS: r = 0.792, P < .001, n = 75; NST-WHtR: r = 0.671, P < .001, n = 43). In CP, systolic BP correlated with NST (r = 0.575, P < .001), BMI SDS (r = 0.434, P = .004), and WHtR (r = 0.386, P = .011). Similar results were observed for diastolic BP in CP. In multivariate analyses, NST had a predictive value for hypertension in postpubertal CP and controls (odds ratio 6.98, 95% confidence interval [1.65, 29.5], P = .008). During a longitudinal follow-up, changes in NST correlated with changes in BMI SDS (P < .001) and WHtR (P = .01) but not with changes in BP and functional capacity.

conclusionsBecause monitoring of magnetic resonance imaging and BC is essential for follow-up in CP, NST could serve as a novel and clinically relevant parameter for longitudinal assessment of BC and CVD risk in CP.

Indexed as

Body Mass IndexRegistriesSkinfold ThicknessWaist-Height RatioAdolescentAdultAge of OnsetBlood PressureBody CompositionCardiovascular DiseasesChildChild, PreschoolCraniopharyngiomaCross-Sectional StudiesFemaleFollow-Up Studies

Identifiers

PMID27680877
PMCPMC5155678
OpenAlexW2524298693

What OpenQuestion holds

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LicenceCC BY-NC
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.