ArticleThe Journal of clinical endocrinology and metabolism2016
Independent Contributions of Nocturnal Hot Flashes and Sleep Disturbance to Depression in Estrogen-Deprived Women.
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Article in The Journal of clinical endocrinology and metabolism, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
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27citing papers in PubMed, 2 pooled it
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Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 74 citations in OpenAlex.
- Vasomotor Symptoms and Their Association with Depressive and Anxiety Symptoms in Peri- and Postmenopausal Women: A Systematic Review of Observational Studies.Medicina (Kaunas, Lithuania) · 2026Pooled it
- Pooled it
- Characterizing the spectrum of distress symptoms in midlife women with perimenopausal depression.Journal of affective disorders · 2026Trial
- Sleep Disruption in the Menopausal Transition and Postmenopause: A Narrative Review.Obstetrics and gynecology · 2026Review
- Adverse Cardiometabolic Impacts of Sleep Fragmentation and Estradiol Suppression: An Experimental Model of Menopause.The Journal of clinical endocrinology and metabolism · 2026Article
- Sex differences in neuromodulatory subcortical systems and their implications for Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Sleep Disturbance and Perimenopause: A Narrative Review.Journal of clinical medicine · 2025Review
- A non-randomized pre-post pilot study of cooling bed sheets in hot sleeping people.Frontiers in sleep · 2025Article
- Depressive symptoms over the final menstrual period: Study of Women's Health Across the Nation (SWAN).Journal of affective disorders · 2024Article
- Article
- The intersection between menopause and depression: overview of research using animal models.Frontiers in psychiatry · 2024Review
- Effects of Sleep Fragmentation and Estradiol Decline on Cortisol in a Human Experimental Model of Menopause.The Journal of clinical endocrinology and metabolism · 2023Article
- Neuroendocrine pathogenesis of perimenopausal depression.Frontiers in psychiatry · 2023Review
- Hot flashes, insomnia, and the reproductive stages: a cross-sectional observation of women from the EPISONO study.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2021Article
- Orexin and Alzheimer's Disease: A New Perspective.Psychiatry investigation · 2020Article
- Impact of Estradiol Variability and Progesterone on Mood in Perimenopausal Women With Depressive Symptoms.The Journal of clinical endocrinology and metabolism · 2020Observational
- Psychosocial and health-related risk factors for depressive symptom trajectories among midlife women over 15 years: Study of Women's Health Across the Nation (SWAN).Psychological medicine · 2019Article
- Dietary total antioxidant capacity is inversely associated with depression, anxiety and some oxidative stress biomarkers in postmenopausal women: a cross-sectional study.Annals of general psychiatry · 2019Article
- Sleep, Health, and Metabolism in Midlife Women and Menopause: Food for Thought.Obstetrics and gynecology clinics of North America · 2018Review
- Depression During and After the Perimenopause: Impact of Hormones, Genetics, and Environmental Determinants of Disease.Obstetrics and gynecology clinics of North America · 2018 · on this mapReview
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Authors and funding
10 authors at 3 institutions in 1 country.
Hadine JoffeDepartment of Psychiatry (H.J., S.K., J.C.), Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115; Department of Psychosocial Oncology and Palliative Care (H.J.), Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02215; Department of Psychiatry (H.J., M.P.F., N.E., L.S.C.), Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114; Department of Medicine (S.L.C.), Division of Preventive and Behavioral Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01655; Division of Sleep Medicine (D.P.W.), Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115; Sleep Division, Department of Neurology (M.T.B.), and Reproductive Endocrine Unit, Department of Medicine (J.E.H.), Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114; and National Institute of Environmental Health Sciences (J.E.H.), National Institutes of Health, Research Triangle Park, North Carolina 27709.
Sybil L CrawfordDepartment of Psychiatry (H.J., S.K., J.C.), Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115; Department of Psychosocial Oncology and Palliative Care (H.J.), Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02215; Department of Psychiatry (H.J., M.P.F., N.E., L.S.C.), Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114; Department of Medicine (S.L.C.), Division of Preventive and Behavioral Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01655; Division of Sleep Medicine (D.P.W.), Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115; Sleep Division, Department of Neurology (M.T.B.), and Reproductive Endocrine Unit, Department of Medicine (J.E.H.), Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114; and National Institute of Environmental Health Sciences (J.E.H.), National Institutes of Health, Research Triangle Park, North Carolina 27709.
Marlene P FreemanDepartment of Psychiatry (H.J., S.K., J.C.), Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115; Department of Psychosocial Oncology and Palliative Care (H.J.), Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02215; Department of Psychiatry (H.J., M.P.F., N.E., L.S.C.), Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114; Department of Medicine (S.L.C.), Division of Preventive and Behavioral Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01655; Division of Sleep Medicine (D.P.W.), Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115; Sleep Division, Department of Neurology (M.T.B.), and Reproductive Endocrine Unit, Department of Medicine (J.E.H.), Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114; and National Institute of Environmental Health Sciences (J.E.H.), National Institutes of Health, Research Triangle Park, North Carolina 27709.
David P WhiteDepartment of Psychiatry (H.J., S.K., J.C.), Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115; Department of Psychosocial Oncology and Palliative Care (H.J.), Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02215; Department of Psychiatry (H.J., M.P.F., N.E., L.S.C.), Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114; Department of Medicine (S.L.C.), Division of Preventive and Behavioral Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01655; Division of Sleep Medicine (D.P.W.), Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115; Sleep Division, Department of Neurology (M.T.B.), and Reproductive Endocrine Unit, Department of Medicine (J.E.H.), Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114; and National Institute of Environmental Health Sciences (J.E.H.), National Institutes of Health, Research Triangle Park, North Carolina 27709.
Matt T BianchiDepartment of Psychiatry (H.J., S.K., J.C.), Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115; Department of Psychosocial Oncology and Palliative Care (H.J.), Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02215; Department of Psychiatry (H.J., M.P.F., N.E., L.S.C.), Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114; Department of Medicine (S.L.C.), Division of Preventive and Behavioral Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01655; Division of Sleep Medicine (D.P.W.), Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115; Sleep Division, Department of Neurology (M.T.B.), and Reproductive Endocrine Unit, Department of Medicine (J.E.H.), Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114; and National Institute of Environmental Health Sciences (J.E.H.), National Institutes of Health, Research Triangle Park, North Carolina 27709.
Semmie KimDepartment of Psychiatry (H.J., S.K., J.C.), Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115; Department of Psychosocial Oncology and Palliative Care (H.J.), Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02215; Department of Psychiatry (H.J., M.P.F., N.E., L.S.C.), Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114; Department of Medicine (S.L.C.), Division of Preventive and Behavioral Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01655; Division of Sleep Medicine (D.P.W.), Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115; Sleep Division, Department of Neurology (M.T.B.), and Reproductive Endocrine Unit, Department of Medicine (J.E.H.), Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114; and National Institute of Environmental Health Sciences (J.E.H.), National Institutes of Health, Research Triangle Park, North Carolina 27709.
Nicole EconomouDepartment of Psychiatry (H.J., S.K., J.C.), Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115; Department of Psychosocial Oncology and Palliative Care (H.J.), Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02215; Department of Psychiatry (H.J., M.P.F., N.E., L.S.C.), Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114; Department of Medicine (S.L.C.), Division of Preventive and Behavioral Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01655; Division of Sleep Medicine (D.P.W.), Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115; Sleep Division, Department of Neurology (M.T.B.), and Reproductive Endocrine Unit, Department of Medicine (J.E.H.), Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114; and National Institute of Environmental Health Sciences (J.E.H.), National Institutes of Health, Research Triangle Park, North Carolina 27709.
Julie CamusoDepartment of Psychiatry (H.J., S.K., J.C.), Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115; Department of Psychosocial Oncology and Palliative Care (H.J.), Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02215; Department of Psychiatry (H.J., M.P.F., N.E., L.S.C.), Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114; Department of Medicine (S.L.C.), Division of Preventive and Behavioral Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01655; Division of Sleep Medicine (D.P.W.), Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115; Sleep Division, Department of Neurology (M.T.B.), and Reproductive Endocrine Unit, Department of Medicine (J.E.H.), Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114; and National Institute of Environmental Health Sciences (J.E.H.), National Institutes of Health, Research Triangle Park, North Carolina 27709.
Janet E HallDepartment of Psychiatry (H.J., S.K., J.C.), Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115; Department of Psychosocial Oncology and Palliative Care (H.J.), Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02215; Department of Psychiatry (H.J., M.P.F., N.E., L.S.C.), Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114; Department of Medicine (S.L.C.), Division of Preventive and Behavioral Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01655; Division of Sleep Medicine (D.P.W.), Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115; Sleep Division, Department of Neurology (M.T.B.), and Reproductive Endocrine Unit, Department of Medicine (J.E.H.), Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114; and National Institute of Environmental Health Sciences (J.E.H.), National Institutes of Health, Research Triangle Park, North Carolina 27709.
Lee S CohenDepartment of Psychiatry (H.J., S.K., J.C.), Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115; Department of Psychosocial Oncology and Palliative Care (H.J.), Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02215; Department of Psychiatry (H.J., M.P.F., N.E., L.S.C.), Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114; Department of Medicine (S.L.C.), Division of Preventive and Behavioral Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01655; Division of Sleep Medicine (D.P.W.), Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115; Sleep Division, Department of Neurology (M.T.B.), and Reproductive Endocrine Unit, Department of Medicine (J.E.H.), Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114; and National Institute of Environmental Health Sciences (J.E.H.), National Institutes of Health, Research Triangle Park, North Carolina 27709.
Harvard University · USBrigham and Women's Hospital · USUniversity of Massachusetts Chan Medical School · US
Funding
Defining the Mechanisms of Menopause-Associated Sleep and Mood DisturbancesR01MH082922 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI JOFFE, HADINE · 2009 to 2013
$2.0MNIMH NIH HHS R01 MH082922
Abstract
contextWomen are at increased risk for mood disturbance during the menopause transition. Hot flashes (HFs), sleep disruption, and fluctuating estradiol levels correlate with menopause-associated depression but co-occur, making cause and effect relationships difficult to disentangle.
objectiveUsing a GnRH agonist (GnRHa) experimental model, we investigated whether depressive symptoms are associated with HFs and/or are explained by concomitant sleep fragmentation in the absence of estradiol fluctuation. DESIGN AND
interventionDepressive symptoms, objective polysomnographic sleep parameters, subjective sleep quality, serum estradiol, and HFs were assessed before and 4 weeks after open-label depot GnRHa (leuprolide 3.75-mg) administration.
settingAcademic medical center.
participantsTwenty-nine healthy nondepressed premenopausal volunteers (mean age, 27.3 years).
resultsSerum estradiol was rapidly and uniformly suppressed. HFs developed in 69% of the subjects. On univariate analysis, worsening of mood was predicted by increases in time in light sleep (stage N1), number of transitions to wake, non-REM arousals, subjective sleep quality, and reductions in perceived sleep efficiency (all P < .045), as well as the number of nighttime (P = .006), but not daytime (P = .28), HFs reported. In adjusted models, the number of nighttime HFs reported, increases in non-REM arousals, time in stage N1, transitions to wake, and reduced sleep quality remained significant predictors of mood deterioration (P ≤ .05).
conclusionsDepressive symptoms emerged after estradiol withdrawal in association with objectively and subjectively measured sleep disturbance and the number of nighttime, but not daytime, HFs reported. Results suggest that sleep disruption and perceived nighttime HFs both contribute to vulnerability to menopause-associated depressive symptoms in hypoestrogenic women.
Indexed as
AdolescentAdultDepressionEstradiolFertility Agents, FemaleGonadotropin-Releasing HormoneHealthy VolunteersHot FlashesHumansLeuprolideMenopauseMiddle AgedSleep Wake DisordersYoung AdultEstradiolFertility Agents, FemaleGonadotropin-Releasing HormoneLeuprolide
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