Evidence map›Paper›PMID 27680405›Full record

Trial reportEnvironment international2016

Biomonitoring Human Exposure to Household Air Pollution and Association with Self-reported Health Symptoms - A Stove Intervention Study in Peru.

Zheng Li, Adwoa Commodore, Stella Hartinger, Michael Lewin, Andreas Sjödin, Erin Pittman, Debra Trinidad, Kendra Hubbard, Claudio F Lanata, Ana I Gil and 2 more

Open access · greenAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Environment international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Air Pollution and Headache Disorders.Annals of Indian Academy of Neurology · 2022
    Article
  5. Effects of Polycyclic Aromatic Hydrocarbons on Lung Function in Children with Asthma: A Mediation Analysis.International journal of environmental research and public health · 2022
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 3 countries.

Zheng LiCenters for Disease Control and Prevention, National Center for Environmental Health, Atlanta, USA; Agency for Toxic Substances and Disease Registry, Division of Toxicology and Human Health Sciences, Atlanta, USA. Electronic address: ZJLi@cdc.gov.
Adwoa CommodoreMedical University of South Carolina, Charleston, USA.
Stella HartingerInstituto de Investigación Nutricional, Lima, Perú; Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland; Universidad Peruana Cayetano Heredia, Lima, Perú.
Michael LewinAgency for Toxic Substances and Disease Registry, Division of Toxicology and Human Health Sciences, Atlanta, USA.
Andreas SjödinCenters for Disease Control and Prevention, National Center for Environmental Health, Atlanta, USA.
Erin PittmanCenters for Disease Control and Prevention, National Center for Environmental Health, Atlanta, USA.
Debra TrinidadCenters for Disease Control and Prevention, National Center for Environmental Health, Atlanta, USA.
Kendra HubbardCenters for Disease Control and Prevention, National Center for Environmental Health, Atlanta, USA.
Claudio F LanataInstituto de Investigación Nutricional, Lima, Perú.
Ana I GilInstituto de Investigación Nutricional, Lima, Perú.
Daniel MäusezahlSwiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland.
Luke P NaeherUniversidad Peruana Cayetano Heredia, Lima, Perú; University of Georgia, Athens, USA.
Centers for Disease Control and Prevention · USInstituto de Investigación Nutricional · PENational Center for Environmental Health · USUniversidad Peruana Cayetano Heredia · PEAgency for Toxic Substances and Disease Registry · USMedical University of South Carolina · USSwiss Tropical and Public Health Institute · CH

Funding

Deep South Occupational Safety & Health Education & Research Center-SupplementT42OH008436 · OH · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LUNGU, CLAUDIU T · 2005 to 2025
$28.8M
Respiratory, reproductive, and other effects of air pollution and high altitudeD43TW005746 · FIC · EMORY UNIVERSITY · PI STEENLAND, NELSON K · 2001 to 2012
$1.9M
ACL HHS T42OH008436FIC NIH HHS D43 TW005746Intramural CDC HHS CC999999NIOSH CDC HHS T42 OH008436
6 · The paper itself

Abstract

backgroundHousehold air pollution (HAP) from indoor biomass stoves contains harmful pollutants, such as polycyclic aromatic hydrocarbons (PAHs), and is a leading risk factor for global disease burden. We used biomonitoring to assess HAP exposure and association with self-reported symptoms in 334 non-smoking Peruvian women to evaluate the efficacy of a stove intervention program.

methodsWe conducted a cross-sectional study within the framework of a community randomized control trial. Using urinary PAH metabolites (OH-PAHs) as the exposure biomarkers, we investigated whether the intervention group (n=155, with new chimney-equipped stoves) were less exposed to HAP compared to the control group (n=179, with mostly open-fire stoves). We also estimated associations between the exposure biomarkers, risk factors, and self-reported health symptoms, such as recent eye conditions, respiratory conditions, and headache.

resultsWe observed reduced headache and ocular symptoms in the intervention group than the control group. Urinary 2-naphthol, a suggested biomarker for inhalation PAH exposure, was significantly lower in the intervention group (GM with 95% CI: 13.4 [12.3, 14.6] μg/g creatinine) compared to control group (16.5 [15.0, 18.0] μg/g creatinine). Stove type and/or 2-naphthol was associated with a number of self-reported symptoms, such as red eye (adjusted OR with 95% CI: 3.80 [1.32, 10.9]) in the past 48h.

conclusionsEven with the improved stoves, the biomarker concentrations in this study far exceeded those of the general populations and were higher than a no-observed-genotoxic-effect-level, indicating high exposure and a potential for increased cancer risk in the population.

Indexed as

CookingSelf ReportAdultAir Pollution, IndoorBiomarkersBiomassCross-Sectional StudiesEnvironmental ExposureEnvironmental MonitoringEye DiseasesFemaleFiresHeadacheHumansInhalation ExposureNaphthols2-naphtholBiomarkersNaphtholsPolycyclic Aromatic HydrocarbonsSmoke1-hydroxypyrenebiomonitoringhousehold air pollutionpolycyclic aromatic hydrocarbonstove interventionwoodsmoke

Identifiers

PMID27680405
PMCPMC5154792
OpenAlexW2521806306

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.