Evidence map›Paper›PMID 27680298›Full record

ArticleJournal of proteome research2016

APOSTL: An Interactive Galaxy Pipeline for Reproducible Analysis of Affinity Proteomics Data.

Brent M Kuenzi, Adam L Borne, Jiannong Li, Eric B Haura, Steven A Eschrich, John M Koomen, Uwe Rix, Paul A Stewart

Abstract read
In one paragraph

Article in Journal of proteome research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

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  8. Proximity labeling reveals novel interactomes in liveDevelopment (Cambridge, England) · 2019
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Brent M KuenziDepartment of Drug Discovery, H. Lee Moffitt Cancer Center & Research Institute , Tampa, Florida 33612-9497, United States.
Adam L BorneDepartment of Thoracic Oncology, H. Lee Moffitt Cancer Center & Research Institute , Tampa, Florida 33612-9497, United States.
Jiannong LiDepartment of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center & Research Institute , Tampa, Florida 33612-9497, United States.
Eric B HauraDepartment of Thoracic Oncology, H. Lee Moffitt Cancer Center & Research Institute , Tampa, Florida 33612-9497, United States.
Steven A EschrichDepartment of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center & Research Institute , Tampa, Florida 33612-9497, United States.
John M KoomenMolecular Oncology, H. Lee Moffitt Cancer Center & Research Institute , Tampa, Florida 33612-9497, United States.
Uwe RixDepartment of Drug Discovery, H. Lee Moffitt Cancer Center & Research Institute , Tampa, Florida 33612-9497, United States.
Paul A StewartDepartment of Thoracic Oncology, H. Lee Moffitt Cancer Center & Research Institute , Tampa, Florida 33612-9497, United States.

Funding

TRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI John L. Cleveland · 1998 to 2026
$93.5M
Harnessing beneficial off-target effects of kinase inhibitors in lung cancerR01CA181746 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI RIX, UWE · 2015 to 2019
$2.3M
New therapeutic opportunities from mining polypharmacology mechanisms of ceritinib in ALK-negative non-small cell lung cancerF99CA212456 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI KUENZI, BRENT · 2016 to 2017
$70k
NCI NIH HHS F99 CA212456NCI NIH HHS P30 CA076292NCI NIH HHS R01 CA181746
6 · The paper itself

Abstract

With continuously increasing scale and depth of coverage in affinity proteomics (AP-MS) data, the analysis and visualization is becoming more challenging. A number of tools have been developed to identify high-confidence interactions; however, a cohesive and intuitive pipeline for analysis and visualization is still needed. Here we present Automated Processing of SAINT Templated Layouts (APOSTL), a freely available Galaxy-integrated software suite and analysis pipeline for reproducible, interactive analysis of AP-MS data. APOSTL contains a number of tools woven together using Galaxy workflows, which are intuitive for the user to move from raw data to publication-quality figures within a single interface. APOSTL is an evolving software project with the potential to customize individual analyses with additional Galaxy tools and widgets using the R web application framework, Shiny. The source code, data, and documentation are freely available from GitHub ( https://github.com/bornea/APOSTL ) and other sources.

Indexed as

WorkflowComputational BiologyProteomicsSoftwareUser-Computer Interfaceaffinity proteomicsAP−MSdata analysisdata visualizationGalaxypipelineSAINTSAINTexpressworkflow

Identifiers

PMID27680298
PMCPMC5231908

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.