Evidence map›Paper›PMID 27679993›Full record

ArticleJournal of fluorescence2017

Green Synthetic Approach for Synthesis of Fluorescent Carbon Dots for Lisinopril Drug Delivery System and their Confirmations in the Cells.

Vaibhavkumar N Mehta, Shiva Shankaran Chettiar, Jigna R Bhamore, Suresh Kumar Kailasa, Ramesh M Patel

Abstract read
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In one paragraph

Article in Journal of fluorescence, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 98 citations in OpenAlex.

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  14. Natural carbon-based quantum dots and their applications in drug delivery: A review.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2020
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Vaibhavkumar N MehtaApplied chemistry Department, S. V. National Institute of Technology, Surat, 395 007, India.
Shiva Shankaran ChettiarDepartment of Biotechnology, Shree Ramkrishna Institute of Computer Education and Applied Sciences, Surat, India.
Jigna R BhamoreApplied chemistry Department, S. V. National Institute of Technology, Surat, 395 007, India.
Suresh Kumar KailasaApplied chemistry Department, S. V. National Institute of Technology, Surat, 395 007, India. sureshkumarchem@gmail.com.
Ramesh M PatelASPEE SHAKILAM Agricultural Biotechnology Institute, Navsari Agricultural University, Surat, 395007, India.
Sardar Vallabhbhai National Institute of Technology Surat · INNavsari Agricultural University · INRamakrishna Mission Vidyamandira · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this work, highly luminescent carbon dots (CDs) were synthesized by the hydrothermal method at 170 °C for 12 h using pasteurized milk as a carbon source. The prepared CDs exhibited bright blue fluorescence under UV light illumination at 365 nm. The CDs show fluorescence life time of ~4.89 ns at excitation wavelength of 370 nm. The effect of different solvents on the fluorescence property of CDs was also investigated. The lisinopril (Lis)-loaded CDs were fabricated by self-assembly of lisinopril on the surfaces of CDs, which were characterized by UV-visible and FT-IR spectroscopic techniques. The controlled release of lisinopril from the Lis-CDs was realized at pH values of 5.2, 6.2 and 7.4, respectively. The results of the cytotoxicity and confocal laser scanning microscopic images indicate that the Lis-CDs were successfully uptaken by HeLa cells without apparent cytotoxicity. The synthesized CDs show great potential as drug vehicles with good biocompatibility, sustained release of lisinopril from CDs, indicating that the CDs can act as a promising drug delivery system for therapeutic delivery and/or bioimaging applications.

Indexed as

Drug Delivery SystemsAntihypertensive AgentsCarbonCell SurvivalFluorescent DyesGreen Chemistry TechnologyHeLa CellsHumansLisinoprilQuantum DotsAntihypertensive AgentsCarbonFluorescent DyesLisinoprilFluorescence microscopyHeLa cellsLis-loaded CDsPasteurized milkUV-visible and fluorescence spectroscopic techniques

Identifiers

PMID27679993
OpenAlexW2525787444

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.