ArticleProceedings of the National Academy of Sciences of the United States of America2016
Compartment and signal-specific codependence in the transcriptional control of Salmonella periplasmic copper homeostasis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 33 citations in OpenAlex.
- The transcriptional regulator CueR positively regulates the expression of theMicrobiology spectrum · 2026Article
- CuiT is a Cu importer required for metal homeostasis inBiochemistry and biophysics reports · 2026Article
- Dual regulation ofmicroLife · 2026Article
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- Genetic Characteristics of Salmonella Isolates Recovered From Reused Broiler Litter Over Three Successive Flocks.Journal of food protection · 2024Article
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- A Copper-Responsive Two-Component System Governs Lipoprotein Remodeling in Listeria monocytogenes.Journal of bacteriology · 2023Article
- An ensemble learning approach to identify pastured poultry farm practice variables and soil constituents that promoteHeliyon · 2022Article
- Unique underlying principles shaping copper homeostasis networks.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2022Review
- Experimental Evolution of Copper Resistance inAntibiotics (Basel, Switzerland) · 2022Article
- Evolution of Copper Homeostasis and Virulence inFrontiers in microbiology · 2022Article
- Copper Homeostatic Mechanisms and Their Role in the Virulence of Escherichia coli and Salmonella enterica.EcoSal Plus · 2021Review
- Copper Handling in the Salmonella Cell Envelope and Its Impact on Virulence.Trends in microbiology · 2021Article
- Maturation ofFrontiers in microbiology · 2021Article
- Article
- The Role ofGenes · 2020Article
- New Roles for Two-Component System Response Regulators ofMicroorganisms · 2020Article
- The CpxAR Two-Component System Contributes to Growth, Stress Resistance, and Virulence ofFrontiers in microbiology · 2020Article
- The Scs disulfide reductase system cooperates with the metallochaperone CueP inThe Journal of biological chemistry · 2019Article
- CpxR/CpxA ControlsJournal of bacteriology · 2018Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Copper homeostasis is essential for bacterial pathogen fitness and infection, and has been the focus of a number of recent studies. In Salmonella, envelope protection against copper overload and macrophage survival depends on CueP, a major copper-binding protein in the periplasm. This protein is also required to deliver the metal ion to the Cu/Zn superoxide dismutase SodCII. The Salmonella-specific CueP-coding gene was originally identified as part of the Cue regulon under the transcriptional control of the cytoplasmic copper sensor CueR, but its expression differs from the rest of CueR-regulated genes. Here we show that cueP expression is controlled by the concerted action of CueR, which detects the presence of copper in the cytoplasm, and by CpxR/CpxA, which monitors envelope stress. Copper-activated CueR is necessary for the appropriate spatial arrangement of the -10 and -35 elements of the cueP promoter, and CpxR is essential to recruit the RNA polymerase. The integration of two ancestral sensory systems-CueR, which provides signal specificity, and CpxR/CpxA, which detects stress in the bacterial envelope-restricts the expression of this periplasmic copper resistance protein solely to cells encountering surplus copper that disturbs envelope homeostasis, emulating the role of the CusR/CusS regulatory system present in other enteric bacteria.
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