ArticleScience advances2016
Single-neuron and genetic correlates of autistic behavior in macaque.
Article in Science advances, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 54 citations in OpenAlex.
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- A General Principle of Neuronal Evolution Reveals a Human-Accelerated Neuron Type Potentially Underlying the High Prevalence of Autism in Humans.Molecular biology and evolution · 2025Article
- Three-dimensional markerless motion capture of multiple freely behaving monkeys toward automated characterization of social behavior.Science advances · 2025Article
- A general principle of neuronal evolution reveals a human-accelerated neuron type potentially underlying the high prevalence of autism in humans.bioRxiv : the preprint server for biology · 2025Article
- Evolutionary constrained genes associated with autism spectrum disorder across 2,054 nonhuman primate genomes.Molecular autism · 2025Article
- Exploring the singularity of human neurons: keep calm and carry on.Frontiers in synaptic neuroscience · 2025Review
- Association ofMolecular syndromology · 2024Article
- Article
- Cognitive genomics of learning delay and low level of social performance monitoring in macaque.Scientific reports · 2022Article
- Exome sequencing analysis of Japanese autism spectrum disorder case-control sample supports an increased burden of synaptic function-related genes.Translational psychiatry · 2022Article
- Heritability of social behavioral phenotypes and preliminary associations with autism spectrum disorder risk genes in rhesus macaques: A whole exome sequencing study.Autism research : official journal of the International Society for Autism Research · 2022Article
- Dedicated Representation of Others in the Macaque Frontal Cortex: From Action Monitoring and Prediction to Outcome Evaluation.Cerebral cortex (New York, N.Y. : 1991) · 2022Review
- "Natural Laboratory Complex" for novel primate neuroscience.Frontiers in integrative neuroscience · 2022Article
- Use of ATP-Binding Cassette Subfamily A Member 13 (ABCA13) for Sensitive Detection of Focal Pathological Forms of Subclinical Bovine Paratuberculosis.Frontiers in veterinary science · 2022Article
- Comparative connectomics of the primate social brain.NeuroImage · 2021Review
- A novel mind-set in primate experimentation: Implications for primate welfare.Animal models and experimental medicine · 2021Review
- Social agent identity cells in the prefrontal cortex of interacting groups of primates.Science (New York, N.Y.) · 2021Article
- Genomic selection signatures in autism spectrum disorder identifies cognitive genomic tradeoff and its relevance in paradoxical phenotypes of deficits versus potentialities.Scientific reports · 2021Article
- ATP-binding cassette transporter 13 mRNA expression level in schizophrenia patients.Scientific reports · 2020Article
- A causal role for frontal cortico-cortical coordination in social action monitoring.Nature communications · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Atypical neurodevelopment in autism spectrum disorder is a mystery, defying explanation despite increasing attention. We report on a Japanese macaque that spontaneously exhibited autistic traits, namely, impaired social ability as well as restricted and repetitive behaviors, along with our single-neuron and genomic analyses. Its social ability was measured in a turn-taking task, where two monkeys monitor each other's actions for adaptive behavioral planning. In its brain, the medial frontal neurons responding to others' actions, abundant in the controls, were almost nonexistent. In its genes, whole-exome sequencing and copy number variation analyses identified rare coding variants linked to human neuropsychiatric disorders in 5-hydroxytryptamine (serotonin) receptor 2C (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.