ArticleeNeuro
Physiological, Behavioral, and Scientific Impact of Different Fluid Control Protocols in the Rhesus Macaque (
Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The trial behind it
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Who cites it
28 citing papers in PubMed.
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- Physiological correlates of a simple saccadic-decision task to extended objects in superior colliculus.iScience · 2025Article
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- The Differential Weights of Motivational and Task Performance Measures on Medial and Lateral Frontal Neural Activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Ripples in macaque V1 and V4 are modulated by top-down visual attention.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- A framework and resource for global collaboration in non-human primate neuroscience.Current research in neurobiology · 2023Review
- The Representation of Time Windows in Primate Auditory Cortex.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Dopamine influences attentional rate modulation in Macaque posterior parietal cortex.Scientific reports · 2022Article
- Stimulus dependence of directed information exchange between cortical layers in macaque V1.eLife · 2022Article
- Neuronal figure-ground responses in primate primary auditory cortex.Cell reports · 2021Article
- Contribution of Ionotropic Glutamatergic Receptors to Excitability and Attentional Signals in Macaque Frontal Eye Field.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Effects of muscarinic and nicotinic receptors on contextual modulation in macaque area V1.Scientific reports · 2021Article
- International primate neuroscience research regulation, public engagement and transparency opportunities.NeuroImage · 2021Review
- Directed information exchange between cortical layers in macaque V1 and V4 and its modulation by selective attention.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Article
- Using non-invasive neuroimaging to enhance the care, well-being and experimental outcomes of laboratory non-human primates (monkeys).NeuroImage · 2021Review
- Beyond MRI: on the scientific value of combining non-human primate neuroimaging with metadata.NeuroImage · 2021Article
- Pacing behaviour in laboratory macaques is an unreliable indicator of acute stress.Scientific reports · 2019Article
- Reward cues readily direct monkeys' auditory performance resulting in broad auditory cortex modulation and interaction with sites along cholinergic and dopaminergic pathways.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Rhesus macaques are an important model in behavioral neuroscience due to their advanced cognitive abilities. To motivate animals to engage in complex tasks, fluid rewards, in conjunction with fluid control protocols, are often used. The impact of these protocols on animal welfare is controversial. We compared two fluid control protocols against a protocol providing free access to water and evaluated the impacts on physiological states of hydration, behavioral measures of welfare, and scientific output. Blood physiology did not significantly differ between any of the protocols, and urine measures were indicative of well functioning, healthy kidneys. Changes in behaviors were limited, the main one being an increase in motivation to drink on the stricter fluid control protocol, and improved task performance early in the week. Overall, fluid control protocols had little measurable impact on the welfare of rhesus macaques while ensuring that scientific data of high quality could be obtained.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.