Evidence map›Paper›PMID 27679798›Full record

ReviewFrontiers in cell and developmental biology2016

The Role of Cardiac Side Population Cells in Cardiac Regeneration.

Amritha Yellamilli, Jop H van Berlo

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in cell and developmental biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 28 citations in OpenAlex.

  1. Heart-derived endogenous stem cells.Molecular biology reports · 2025
    Review
  2. MuSCs and IPCs: roles in skeletal muscle homeostasis, aging and injury.Cellular and molecular life sciences : CMLS · 2024
    Review
  3. Article
  4. Review
  5. Abcg2-expressing side population cells contribute to cardiomyocyte renewal through fusion.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020
    Article
  6. Article
  7. Review
  8. Profiling proliferative cells and their progeny in damaged murine hearts.Proceedings of the National Academy of Sciences of the United States of America · 2018
    Article
  9. Review
  10. Review
  11. Article
  12. Decline in cellular function of aged mouse c-kitThe Journal of physiology · 2017
    Article
  13. Targeting BCRP/ABCG2 by RNA interference enhances the chemotherapy sensitivity of human colon cancer side population cells.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Amritha YellamilliStem Cell Institute, University of MinnesotaMinneapolis, MN, USA; Lillehei Heart Institute, University of MinnesotaMinneapolis, MN, USA; Department of Integrative Biology and Physiology, University of MinnesotaMinneapolis, MN, USA.
Jop H van BerloStem Cell Institute, University of MinnesotaMinneapolis, MN, USA; Lillehei Heart Institute, University of MinnesotaMinneapolis, MN, USA; Department of Integrative Biology and Physiology, University of MinnesotaMinneapolis, MN, USA; Department of Medicine/Cardiology, University of MinnesotaMinneapolis, MN, USA.
University of Minnesota · US

Funding

Strategic activation of endogenous c-kit+ progenitor cells for cardiac regenerationR01HL130072 · NHLBI · UNIVERSITY OF MINNESOTA · PI VAN BERLO, JOHANNES (JOP) · 2016 to 2020
$1.9M
Functional relevance of cardiac regeneration by c-kit positive stem cellsR00HL112852 · NHLBI · UNIVERSITY OF MINNESOTA · PI VAN BERLO, JOHANNES (JOP) · 2013 to 2015
$712k
Functional relevance of cardiac regeneration by c-kit positive stem cellsK99HL112852 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI VAN BERLO, JOHANNES (JOP) · 2012 to 2013
$263k
NHLBI NIH HHS K99 HL112852NHLBI NIH HHS R00 HL112852NHLBI NIH HHS R01 HL130072
6 · The paper itself

Abstract

The heart has a limited ability to regenerate. It is important to identify therapeutic strategies that enhance cardiac regeneration in order to replace cardiomyocytes lost during the progression of heart failure. Cardiac progenitor cells are interesting targets for new regenerative therapies because they are self-renewing, multipotent cells located in the heart. Cardiac side population cells (cSPCs), the first cardiac progenitor cells identified in the adult heart, have the ability to differentiate into cardiomyocytes, endothelial cells, smooth muscle cells, and fibroblasts. They become activated in response to cardiac injury and transplantation of cSPCs into the injured heart improves cardiac function. In this review, we will discuss the current literature on the progenitor cell properties and therapeutic potential of cSPCs. This body of work demonstrates the great promise cSPCs hold as targets for new regenerative strategies.

Indexed as

Abcg2cardiac regenerationheart failureside populationstem cells

Identifiers

PMID27679798
PMCPMC5020051
OpenAlexW2520905422

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.