ArticleClinical kidney journal2016
Iohexol plasma clearance for measuring glomerular filtration rate in clinical practice and research: a review. Part 2: Why to measure glomerular filtration rate with iohexol?
Article in Clinical kidney journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers.
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Who cites it
82 citing papers in PubMed, 218 citations in OpenAlex.
- Reliability of glomerular filtration rate estimating formulas compared to iohexol plasma clearance in critically ill children.European journal of pediatrics · 2022Trial
- Iohexol plasma and urinary concentrations in cirrhotic patients: A pilot study.World journal of hepatology · 2022Trial
- Accuracy of single intravenous access iohexol GFR in children is hampered by marker contamination.Scientific reports · 2021Trial
- Iohexol plasma clearance in children: validation of multiple formulas and single-point sampling times.Pediatric nephrology (Berlin, Germany) · 2018Trial
- Kidney failure risk equation and early renal risk in adults with sickle cell disease: comparison with KDIGO classification using measured GFR.Renal failure · 2026Article
- Toward the Future: A Race-Agnostic, Bayesian Approach to Defining Glomerular Filtration for Personalized Drug Dosing.Clinical pharmacology and therapeutics · 2026Review
- Gold Standard GFR measurement and GFR estimation in pediatric oncology - indications and limitations.Pediatric nephrology (Berlin, Germany) · 2026Review
- Clearance of mannitol for assessment of glomerular filtration rate in chronic kidney disease: A validation against iohexol clearance.Clinical physiology and functional imaging · 2026Article
- Accurate Estimation of Glomerular Filtration Rate in Critically Ill Infants and Children Using a Iohexol Population Pharmacokinetic Modeling Approach.Clinical pharmacokinetics · 2026Article
- Comparison of DTPA camera-based Gates method versus plasma-clearance methods for assessment of GFR in cirrhosis: A pilot study.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2026Article
- Performance of creatinine and cystatin C-based equations to estimate glomerular filtration rate in African children with sickle cell anemia.Pediatric nephrology (Berlin, Germany) · 2026Article
- Renal clearance of endogenous lithium as a marker of proximal tubule function in sepsis and sepsis-associated acute kidney injury : A prospective single-centre study.BMC nephrology · 2026Observational
- Pelvi-Ureteric Junction Obstruction in a Solitary Functioning Kidney in Children: An Unfavourable Combination.Acta paediatrica (Oslo, Norway : 1992) · 2026Article
- Advancements in Renal Imaging: A Comprehensive Systematic Review of PET Probes for Enhanced GFR and Renal Perfusion Assessment.Diagnostics (Basel, Switzerland) · 2025Review
- Pharmacokinetic Study of Carboplatin Using Various Overweight-Correcting Dosing Algorithms and Biomarkers in Patients With Varying BMI Categories.Therapeutic drug monitoring · 2025Article
- Measuring and estimating the GFR in children: state of the art in 2025.Pediatric nephrology (Berlin, Germany) · 2025Review
- Asymmetric dimethylarginine and citrulline are risk factors for cardiovascular disease independently of both estimated and measured GFR.Clinical kidney journal · 2025Article
- Determination of Glomerular Filtration Rate After Contrast-Enhanced CT Among Critically Ill Patients: Support for a New Procedure.Critical care explorations · 2025Observational
- Performance of the 2021 Estimated Glomerular Filtration Rate CKD-EPI Refit and the European Kidney Function Consortium (EKFC) Formulas.Diagnostics (Basel, Switzerland) · 2025Article
- Early life factors and variation in adult kidney function in the Swedish LifeGene cohort.Scientific reports · 2025Article
22 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
17 authors at 11 institutions in 7 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A reliable assessment of glomerular filtration rate (GFR) is of paramount importance in clinical practice as well as epidemiological and clinical research settings. It is recommended by Kidney Disease: Improving Global Outcomes guidelines in specific populations (anorectic, cirrhotic, obese, renal and non-renal transplant patients) where estimation equations are unreliable. Measured GFR is the only valuable test to confirm or confute the status of chronic kidney disease (CKD), to evaluate the slope of renal function decay over time, to assess the suitability of living kidney donors and for dosing of potentially toxic medication with a narrow therapeutic index. Abnormally elevated GFR or hyperfiltration in patients with diabetes or obesity can be correctly diagnosed only by measuring GFR. GFR measurement contributes to assessing the true CKD prevalence rate, avoiding discrepancies due to GFR estimation with different equations. Using measured GFR, successfully accomplished in large epidemiological studies, is the only way to study the potential link between decreased renal function and cardiovascular or total mortality, being sure that this association is not due to confounders, i.e. non-GFR determinants of biomarkers. In clinical research, it has been shown that measured GFR (or measured GFR slope) as a secondary endpoint as compared with estimated GFR detected subtle treatment effects and obtained these results with a comparatively smaller sample size than trials choosing estimated GFR. Measuring GFR by iohexol has several advantages: simplicity, low cost, stability and low interlaboratory variation. Iohexol plasma clearance represents the best chance for implementing a standardized GFR measurement protocol applicable worldwide both in clinical practice and in research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.