ArticleFrontiers in microbiology2016
Antimicrobial Activity and Mechanism of Inhibition of Silver Nanoparticles against Extreme Halophilic Archaea.
Article in Frontiers in microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Antibiofilm potential of biogenic magnesium oxide nanoparticles against multidrug resistant gram-negative bacteria.International microbiology : the official journal of the Spanish Society for Microbiology · 2026Article
- Paenibacillus barengoltzii: isolation, growth, and characterization of a high dextrinizer α-amylase.Biotechnology letters · 2025Article
- Article
- Antibacterial activity and mechanism of X33 antimicrobial oligopeptide againstSynthetic and systems biotechnology · 2024Article
- Bacterioruberin: Biosynthesis, Antioxidant Activity, and Therapeutic Applications in Cancer and Immune Pathologies.Marine drugs · 2024Review
- Challenges and prospects of microbial α-amylases for industrial application: a review.World journal of microbiology & biotechnology · 2023Review
- Oxidative stress generated due to photocatalytic activity of biosynthesized selenium nanoparticles triggers cytoplasmic leakage leading to bacterial cell death.RSC advances · 2023Article
- Antibacterial Mechanisms of Zinc Oxide Nanoparticle against Bacterial Food Pathogens Resistant to Beta-Lactam Antibiotics.Molecules (Basel, Switzerland) · 2022Article
- A Twist to the Kirby-Bauer Disk Diffusion Susceptibility Test: an Accessible Laboratory Experiment Comparing Haloferax volcanii and Escherichia coli Antibiotic Susceptibility to Highlight the Unique Cell Biology of Archaea.Journal of microbiology & biology education · 2022Article
- Biogenic Silver Nanoparticles Strategically Combined WithFrontiers in microbiology · 2022Article
- Accessible and Insightful Scientific Learning Experiences Using the Microorganism Haloferax volcanii.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Synthesis of silver nanoparticles conjugated with kaempferol and hydrocortisone and an evaluation of their antibacterial effects.3 Biotech · 2021Article
- Biogenic Silver Nanoparticles Decorated with Methylene Blue Potentiated the Photodynamic Inactivation ofPharmaceutics · 2020Article
- Anthracycline Shunt Metabolites From Philippine Marine Sediment-DerivedFrontiers in microbiology · 2020Article
- Editorial: Alternative Therapeutics Against Antimicrobial-Resistant Pathogens.Frontiers in microbiology · 2019Article
- Three-dimensional models of Mycobacterium tuberculosis proteins Rv1555, Rv1554 and their docking analyses with sildenafil, tadalafil, vardenafil drugs, suggest interference with quinol binding likely to affect protein's function.BMC structural biology · 2018Article
- Jacalin capped platinum nanoparticles confer persistent immunity against multiple Aeromonas infection in zebrafish.Scientific reports · 2018Article
- Emphasized Mechanistic Antimicrobial Study of Biofunctionalized Silver Nanoparticles on ModelJournal of drug delivery · 2018Article
- Mechanism of Anti-bacterial Activity of Zinc Oxide Nanoparticle Against Carbapenem-ResistantFrontiers in microbiology · 2018Article
- Response of extreme haloarchaeon Haloarcula argentinensis RR10 to simulated microgravity in clinorotation.3 Biotech · 2017Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Haloarchaea are salt-loving halophilic microorganisms that inhabit marine environments, sea water, salterns, and lakes. The resistance of haloarchaea to physical extremities that challenge organismic survival is ubiquitous. Metal and antibiotic resistance of haloarchaea has been on an upsurge due to the exposure of these organisms to metal sinks and drug resistance genes augmented in their natural habitats due to anthropogenic activities and environmental pollution. The efficacy of silver nanoparticles (SNPs) as a potent and broad spectrum inhibitory agent is known, however, there are no reports on the inhibitory activity of SNPs against haloarchaea. In the present study, we have investigated the antimicrobial potentials of SNPs synthesized using aqueous leaf extract of Cinnamomum tamala against antibiotic resistant haloarchaeal isolates Haloferax prahovense RR8, Haloferax lucentense RR15, Haloarcula argentinensis RR10 and Haloarcula tradensis RR13. The synthesized SNPs were characterized by UV-Vis spectroscopy, scanning electron microscopy, energy dispersive X-ray spectroscopy, dynamic light scattering, X-ray diffraction and Fourier transform infrared spectroscopy. The SNPs demonstrated potent antimicrobial activity against the haloarchaea with a minimum inhibitory concentration of 300-400 μg/ml. Growth kinetics of haloarchaea in the presence of SNPs was studied by employing the Baranyi mathematical model for microbial growth using the DMFit curve fitting program. The C. tamala SNPs also demonstrated cytotoxic activity against human lung adenocarcinoma epithelial cell line (A540) and human breast adenocarcinoma cell line (MCF-7). The mechanism of inhibition of haloarchaea by the SNPs was investigated. The plausible mechanism proposed is the alterations and disruption of haloarchaeal membrane permeability by turbulence, inhibition of respiratory dehydrogenases and lipid peroxidation causing cellular and DNA damage resulting in cell death.
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