ArticleRadiology and oncology2016
Association between polymorphisms in segregation genes BUB1B and TTK and gastric cancer risk.
Article in Radiology and oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 27 citations in OpenAlex.
- Article
- Common Core Genes Play Vital Roles in Gastric Cancer With Different Stages.Frontiers in genetics · 2022Article
- Aberrant Expression of BUB1B Contributes to the Progression of Thyroid Carcinoma and Predicts Poor Outcomes for Patients.Journal of Cancer · 2022Article
- Association of High Expression of Mitochondrial Fission Regulator 2 with Poor Survival of Patients with Esophageal Squamous Cell Carcinoma.Journal of cancer prevention · 2021Article
- Reversine inhibits proliferation, invasion and migration and induces cell apoptosis in gastric cancer cells by downregulating TTK.Experimental and therapeutic medicine · 2021Article
- Identification of key genes and biological pathways in lung adenocarcinoma via bioinformatics analysis.Molecular and cellular biochemistry · 2021Article
- Identifying of biomarkers associated with gastric cancer based on 11 topological analysis methods of CytoHubba.Scientific reports · 2021Article
- Identification of Seven Cell Cycle-Related Genes with Unfavorable Prognosis and Construction of their TF-miRNA-mRNA regulatory network in Breast Cancer.Journal of Cancer · 2021Article
- Defining an embryonal rhabdomyosarcoma endotype.Cold Spring Harbor molecular case studies · 2020Article
- Prognostic Prediction Using a Stemness Index-Related Signature in a Cohort of Gastric Cancer.Frontiers in molecular biosciences · 2020Article
- Mitotic checkpoint kinase Mps1/TTK predicts prognosis of colon cancer patients and regulates tumor proliferation and differentiation via PKCα/ERK1/2 and PI3K/Akt pathway.Medical oncology (Northwood, London, England) · 2019Article
- Evaluation of core serous epithelial ovarian cancer genes as potential prognostic markers and indicators of the underlying molecular mechanisms using an integrated bioinformatics analysis.Oncology letters · 2019Article
- Identification of significant genes with poor prognosis in ovarian cancer via bioinformatical analysis.Journal of ovarian research · 2019Article
- Identification of five hub genes as monitoring biomarkers for breast cancer metastasis in silico.Hereditas · 2019Article
- Targeting dual specificity protein kinase TTK attenuates tumorigenesis of glioblastoma.Oncotarget · 2018Article
- Genome-wide Analyses on Single Disease Samples for Potential Biomarkers and Biological Features of Molecular Subtypes: A Case Study in Gastric Cancer.International journal of biological sciences · 2018Article
- Protein kinase TTK promotes proliferation and migration and mediates epithelial-mesenchymal transition in human bladder cancer cells.International journal of clinical and experimental pathology · 2018Article
- Comprehensive analysis of differentially expressed genes associated with PLK1 in bladder cancer.BMC cancer · 2017Article
- The FOXM1/BUB1B signaling pathway is essential for the tumorigenicity and radioresistance of glioblastoma.Oncology reports · 2017Article
- Bioinformatics study on genes related to a high-risk postoperative recurrence of lung adenocarcinoma.Science progressArticle
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMalignant transformation of normal gastric cells is a complex and multistep process, resulting in development of heterogeneous tumours. Susceptible genetic background, accumulation of genetic changes, and environmental factors play an important role in gastric carcinogenesis. Single nucleotide polymorphisms (SNPs) in mitotic segregation genes could be responsible for inducing the slow process of accumulation of genetic changes, leading to genome instability. PATIENTS AND
methodsWe performed a case-control study of polymorphisms in mitotic kinases TTK rs151658 and BUB1B rs1031963 and rs1801376 to assess their effects on gastric cancer risk. We examined the TTK abundance in gastric cancer tissues using immunoblot analysis.
resultsC/G genotype of rs151658 was more frequent in patients with diffuse type of gastric cancer and G/G genotype was more common in intestinal types of gastric cancers (p = 0.049). Polymorphic genotype A/A of rs1801376 was associated with higher risk for developing diffuse type of gastric cancer in female population (p = 0.007), whereas A/A frequencies were increased in male patients with subserosa tumour cell infiltration (p = 0.009). T/T genotype of rs1031963 was associated with well differentiated tumours (p = 0.035). TT+CT genotypes of rs1031963 and GG+AG genotypes of rs1801376 were significantly associated with gastric cancer risk (dominant model; OR = 2,929, 95% CI: 1.281-6.700; p = 0.017 and dominant model; OR = 0,364, 95% CI: 0.192-0.691; p = 0.003 respectively).
conclusionsOur results suggest that polymorphisms in mitotic kinases TTK and BUB1B may contribute to gastric tumorigenesis and risk of tumour development. Further investigations on large populations and populations of different ethnicity are needed to determine their clinical utility.
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