ArticleMolecular genetics and genomics : MGG2017
Integrated RNA-seq and sRNA-seq analysis reveals miRNA effects on secondary metabolism in Solanum tuberosum L.
Article in Molecular genetics and genomics : MGG, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 53 citations in OpenAlex.
- MiRNA-based drugs: challenges and delivery strategies.Applied microbiology and biotechnology · 2025Review
- Genome-wide analysis of non-coding RNA reveals the role of a novel miR319c for tuber dormancy release process in potato.Horticulture research · 2025Article
- Potato steroidal glycoalkaloids: properties, biosynthesis, regulation and genetic manipulation.Molecular horticulture · 2024Review
- Predicting abiotic stress-responsive miRNA in plants based on multi-source features fusion and graph neural network.Plant methods · 2024Article
- Biomod2 modeling for predicting the potential ecological distribution of three Fritillaria species under climate change.Scientific reports · 2023Article
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- Identification of microRNAs and their target genes related to the accumulation of anthocyanin in purple potato tubers (Plant direct · 2022Article
- ASRmiRNA: Abiotic Stress-Responsive miRNA Prediction in Plants by Using Machine Learning Algorithms with PseudoInternational journal of molecular sciences · 2022Article
- Biosynthesis of Secondary Metabolites Based on the Regulation of MicroRNAs.BioMed research international · 2022Review
- Revealing the mechanisms of the bioactive ingredients accumulation inFrontiers in plant science · 2022Article
- Identification of miRNAs and their target genes associated with improved maize seed vigor induced by gibberellin.Frontiers in plant science · 2022Article
- MicroRNAs Roles in Plants Secondary Metabolism.Plant signaling & behavior · 2021Review
- The Critical Role of Small RNAs in Regulating Plant Innate Immunity.Biomolecules · 2021Review
- Photocontrol of Axillary Bud Outgrowth by MicroRNAs: Current State-of-the-Art and Novel Perspectives Gained From the Rosebush Model.Frontiers in plant science · 2021Article
- Identification of Small RNAs During High Light Acclimation inFrontiers in plant science · 2021Article
- Investigation of genes associated with petal variations between diploid and autotetraploid in Chinese cabbage (Brassica rapa L. ssp. pekinensis) by RNA-seq and sRNA-seq.Molecular genetics and genomics : MGG · 2020Article
- Transcriptomic and biochemical investigations support the role of rootstock-scion interaction in grapevine berry quality.BMC genomics · 2020Article
- The Mantle Exosome and MicroRNAs of Hyriopsis cumingii Involved in Nacre Color Formation.Marine biotechnology (New York, N.Y.) · 2019Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Light is a major environmental factor that affects metabolic pathways and stimulates the production of secondary metabolites in potato. However, adaptive changes in potato metabolic pathways and physiological functions triggered by light are partly explained by gene expression changes. Regulation of secondary metabolic pathways in potato has been extensively studied at transcriptional level, but little is known about the mechanisms of post-transcriptional regulation by miRNAs. To identify light-responsive miRNAs/mRNAs and construct putative metabolism pathways regulated by the miRNA-mRNA pairs, an integrated omics (sRNAome and transcriptome) analysis was performed to potato under light stimulus. A total of 31 and 48 miRNAs were identified to be differentially expressed in the leaves and tubers, respectively. Among the DEGs, 1353 genes in the leaves and 1841 genes in the tubers were upregulated, while 1595 genes in the leaves and 897 genes in the tubers were downregulated by light. Mapman enrichment analyses showed that genes related to MVA pathway, alkaloids-like, phenylpropanoids, flavonoids, and carotenoids metabolism were significantly upregulated, while genes associated with major CHO metabolism were repressed in the leaves and tubers. Integrated miRNA and mRNA profiles revealed that light-responsive miRNAs are important regulators in alkaloids metabolism, UMP salvage, lipid biosynthesis, and cellulose catabolism. Moreover, several miRNAs may participate in glycoalkaloids metabolism via JA signaling pathway, UDP-glucose biosynthesis and hydroxylation reaction. This study provides a global view of miRNA and mRNA expression profiles in potato response to light, our results suggest that miRNAs might play important roles in secondary metabolic pathways, especially in glycoalkaloid biosynthesis. The findings will enlighten us on the genetic regulation of secondary metabolite pathways and pave the way for future application of genetically engineered potato.
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