ArticleAnnals of biomedical engineering2017
Development of a Smart Pump for Monitoring and Controlling Intraocular Pressure.
Article in Annals of biomedical engineering, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed.
- Modeling complex age-related eye disease.Progress in retinal and eye research · 2024Review
- Accurate Robotic Posterior Capsule Polishing with Tissue Stabilization.IEEE/ASME transactions on mechatronics : a joint publication of the IEEE Industrial Electronics Society and the ASME Dynamic Systems and Control Division · 2024Article
- Boosting the Piezoelectric Sensitivity of Amino Acid Crystals by Mechanical Annealing for the Engineering of Fully Degradable Force Sensors.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- A portable feedback-controlled pump for monitoring eye outflow facility in conscious rats.PloS one · 2023Article
- Simulation of gravity- and pump-driven perfusion techniques for measuring outflow facility of ex vivo and in vivo eyes.PloS one · 2023Article
- Emerging Materials and Technologies with Applications in Flexible Neural Implants: A Comprehensive Review of Current Issues with Neural Devices.Advanced materials (Deerfield Beach, Fla.) · 2021Review
- Effects of acute stress, general anesthetics, tonometry, and temperature on intraocular pressure in rats.Experimental eye research · 2021Article
- Experimental glaucoma model with controllable intraocular pressure history.Scientific reports · 2020Article
- Intracranial pressure modulates aqueous humour dynamics of the eye.The Journal of physiology · 2020Article
- Aqueous Humor Dynamics of the Brown-Norway Rat.Investigative ophthalmology & visual science · 2018Article
- Biodegradable Piezoelectric Force Sensor.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- A Wireless Pressure Sensor for Continuous Monitoring of Intraocular Pressure in Conscious Animals.Annals of biomedical engineering · 2017Article
- Biomechanical aspects of axonal damage in glaucoma: A brief review.Experimental eye research · 2017Review
- Upcoming Methods and Specifications of Continuous Intraocular Pressure Monitoring Systems for Glaucoma.Journal of ophthalmic & vision researchArticle
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Animal models of ocular hypertension are important for glaucoma research but come with experimental costs. Available methods of intraocular pressure (IOP) elevation are not always successful, the amplitude and time course of IOP changes are unpredictable and irreversible, and IOP measurement by tonometry is laborious. Here we present a novel system for monitoring and controlling IOP without these limitations. It consists of a cannula implanted in the anterior chamber of the eye, a pressure sensor that continually measures IOP, and a bidirectional pump driven by control circuitry that can infuse or withdraw fluid to hold IOP at user-desired levels. A portable version was developed for tethered use on rats. We show that rat eyes can be cannulated for months without causing significant anatomical or physiological damage although the animal and its eyes freely move. We show that the system measures IOP with <0.7 mmHg resolution and <0.3 mmHg/month drift and can maintain IOP within a user-specified window of desired levels for any duration necessary. We conclude that the system is ready for cage- or bench-side applications. The results lay the foundation for an implantable version that would give glaucoma researchers unprecedented knowledge and control of IOP in rats and potentially larger animals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.