Evidence map›Paper›PMID 27679431›Full record

SynthesisEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2017

Treating multi-level cervical disc disease with hybrid surgery compared to anterior cervical discectomy and fusion: a systematic review and meta-analysis.

Victor M Lu, Lucy Zhang, Daniel B Scherman, Prashanth J Rao, Ralph J Mobbs, Kevin Phan

Registry-linked trialAbstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05522010 (Dynamic Cervical Implant), which is not on this map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05522010 naunknown statusnot on this mapstarted 2022, after this paper: background citation

Dynamic Cervical Implant (DCI) Versus Anterior Cervical Discectomy And Fusion(ACDF) For The Treatment Of Single-Level Cervical Degenerative Disc Disease (DDD): An RCT

TypeinterventionalSponsorAssiut UniversityRan2022 to 2024Enrolled50ConditionsCervical Degenerative Disc DiseaseArmsCervical spine surgery
3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 46 citations in OpenAlex.

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  9. Changes in the centre of rotation and the anterior bone loss of the vertebral body in Mobi-C artificial disc replacement segments after cervical hybrid surgery: a retrospective study.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2024
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  18. A Comparison of 2 Anterior Hybrid Techniques for 3-Level Cervical Degenerative Disc Disease.Medical science monitor : international medical journal of experimental and clinical research · 2020
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Victor M LuSydney Medical School, The University of Sydney, Sydney, NSW, 2006, Australia. vilu6071@uni.sydney.edu.au.
Lucy ZhangSydney Medical School, The University of Sydney, Sydney, NSW, 2006, Australia.
Daniel B SchermanSydney Medical School, The University of Sydney, Sydney, NSW, 2006, Australia.
Prashanth J RaoSydney Medical School, The University of Sydney, Sydney, NSW, 2006, Australia.
Ralph J MobbsSydney Medical School, The University of Sydney, Sydney, NSW, 2006, Australia.
Kevin PhanSydney Medical School, The University of Sydney, Sydney, NSW, 2006, Australia.
University of Sydney · AUPrince of Wales Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe traditional surgical approach to treat multi-level cervical disc disease (mCDD) has been anterior cervical discectomy and fusion (ACDF). There has been recent development of other surgical approaches to further improve clinical outcomes. Collectively, when elements of these different approaches are combined in surgery, it is known as hybrid surgery (HS) which remains a novel treatment option. A systematic review and meta-analysis was conducted to compare the outcomes of HS versus ACDF for the treatment of mCDD.

methodsRelevant articles were identified from six electronic databases from their inception to January 2016.

resultsFrom 8 relevant studies identified, 169 patients undergoing HS were compared with 193 ACDF procedures. Operative time was greater after HS by 42 min (p < 0.00001), with less intraoperative blood loss by 26 mL (p < 0.00001) and shorter return to work by 32 days (p < 0.00001). In terms of clinical outcomes, HS was associated with greater C2-C7 range of motion (ROM) preservation (p < 0.00001) and less functional impairment (p = 0.008) after surgery compared to ACDF. There was no significant difference between HS and ACDF with respect to postoperative pain (p = 0.12). The postoperative course following HS was not significantly different to ACDF in terms of length of stay (p = 0.24) and postoperative complication rates (p = 0.18).

conclusionsHS is a novel surgical approach to treat mCDD, associated with a greater operative time, less intraoperative blood loss and comparable if not superior clinical outcomes compared to ACDF. While it remains a viable consideration, there is a lack of robust clinical evidence in the literature. Future large prospective registries and randomised trials are warranted to validate the findings of this study.

Indexed as

DiskectomySpinal FusionBlood Loss, SurgicalCervical VertebraeHumansIntervertebral Disc DegenerationIntervertebral Disc DisplacementOperative TimePostoperative ComplicationsPostoperative PainAnterior cervical corpectomy and fusionAnterior cervical discectomy and fusionArthroplastyArtificial disc replacementCervical disc diseaseHybrid surgeryMulti-levelRange of motionSpineSystematic review

Identifiers

PMID27679431
OpenAlexW2524771751

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.