Evidence map›Paper›PMID 27678389›Full record

ArticleJournal of the renin-angiotensin-aldosterone system : JRAAS2016

Volume regulatory hormones and plasma volume in pregnant women with sickle cell disorder.

Bosede B Afolabi, Olajumoke O Oladipo, Alani S Akanmu, Olalekan O Abudu, Olusoga A Sofola, Fiona Broughton Pipkin

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the renin-angiotensin-aldosterone system : JRAAS, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05253781 (Low Dose Aspirin for Preventing Intrauterine Growth Restriction and Preeclampsia in Sickle Cell Pregnancy), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05253781 phase3completednot on this mapstarted 2020, after this paper: background citation

Low Dose Aspirin for Preventing Intrauterine Growth Restriction and Preeclampsia in Sickle Cell Pregnancy (PIPSICKLE): a Randomized Controlled Trial

TypeinterventionalSponsorUniversity of Lagos, NigeriaRan2020 to 2024Enrolled476ConditionsIntrauterine Growth Restriction, Preeclampsia, Sickle Cell Disease, Pregnancy ComplicationsArmsLow-dose aspirin, Placebo
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Evidence-based obstetric management of women with sickle cell disease in low-income countries.Hematology. American Society of Hematology. Education Program · 2022
    Article
  5. Article
  6. Complications in pregnant women with sickle cell disease.Hematology. American Society of Hematology. Education Program · 2019
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Bosede B AfolabiDepartment of Obstetrics and Gynaecology, College of Medicine, University of Lagos, Nigeria bosedeafolabi2003@yahoo.com.
Olajumoke O OladipoDepartment of Pathology, University of Texas Medical Branch, Galveston, USA.
Alani S AkanmuDepartment of Haematology and Blood Transfusion, College of Medicine, University of Lagos, Nigeria.
Olalekan O AbuduDepartment of Obstetrics and Gynaecology, College of Medicine, University of Lagos, Nigeria.
Olusoga A SofolaDepartment of Physiology, College of Medicine, University of Lagos, Nigeria.
Fiona Broughton PipkinDepartment of Obstetrics and Gynaecology, Faculty of Medicine and Health Sciences, University of Nottingham, UK.
University of Lagos · NGThe University of Texas Medical Branch at Galveston · USUniversity of Nottingham · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSickle cell disease (haemoglobin SS (HbSS)) mainly affects those of West African origin and is associated with hypervolaemia. Plasma volume rises by up to 50% in normal pregnancy but was previously found to be paradoxically contracted in late sickle cell pregnancy. The renin-angiotensin-aldosterone system is activated very early in human pregnancy to support the plasma volume expansion. We hypothesised that activation of the renin-angiotensin-aldosterone system would be blunted in pregnant women with sickle cell disease. MATERIALS AND

methodsWe measured plasma volume and concentrations of plasma renin, angiotensinogen, aldosterone and other volume-related hormones in a cross-sectional study of pregnant and non-pregnant Nigerian women with HbSS or HbAA.

resultsPlasma volume was higher in non-pregnant HbSS than HbAA women, but had not risen by 16 weeks, unlike plasma volume in HbAA women. The concentration of plasma renin also rose significantly less by 16 weeks in HbSS; angiotensinogen and aldosterone concentrations increased.

conclusionsThe lower plasma renin concentration at 16 weeks with HbSS could be either primary or secondary to vasoconstriction related to inadequate vasodilator activity. The contracted plasma volume might then stimulate aldosterone synthesis by non-angiotensin II dependent stimulation. Studies of vasodilators such as nitric oxide, vasodilator eicosanoids or the PlGF/VEGF/sFlT-1 axis in pregnant HbSS and HbAA women will test this hypothesis.

Indexed as

plasma volumepregnancyrenin–angiotensin–aldosterone system (RAAS)sickle cell anaemiaSickle cell diseasevolume regulatory hormones

Identifiers

PMID27678389
PMCPMC5843859
OpenAlexW2527393471

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.