ReviewWorld journal of gastroenterology2016
Exploring the metabolic syndrome: Nonalcoholic fatty pancreas disease.
Review in World journal of gastroenterology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers, 4 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
97 citing papers in PubMed, 4 syntheses or guidelines pooled it, 182 citations in OpenAlex.
- Clinical Outcomes of Acute Pancreatitis in Patients with Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD): A Systematic Review and Meta-Analysis.Digestive diseases and sciences · 2026Pooled it
- Prevalence of fatty pancreas and its associations with pancreatic disease and metabolic disorders: a systematic review and meta-analysis of 124 studies.Frontiers in nutrition · 2026Pooled it
- Mechanisms of obesity- and diabetes mellitus-related pancreatic carcinogenesis: a comprehensive and systematic review.Signal transduction and targeted therapy · 2023Pooled it
- Association of Incidence between Pancreatic Adipose Infiltration and Metabolic Syndrome: A Literature Review and Meta-analysis.Computational and mathematical methods in medicine · 2021Pooled it
- Exercise training decreases pancreatic fat content and improves beta cell function regardless of baseline glucose tolerance: a randomised controlled trial.Diabetologia · 2018Trial
- Polycystic Ovary Syndrome Is Associated with Fatty Pancreas Disorder: A Case-Control Study in Non-Diabetic Women.Journal of clinical medicine · 2026Article
- Pancreatic steatosis is associated with exocrine pancreatic dysfunction in children with MASLD: a prospective cross-sectional study.BMC pediatrics · 2026Article
- Association of BCAAs/BCKAs with pancreatic steatosis in patients with type 2 diabetes mellitus: A cross-sectional study.Journal of diabetes investigation · 2026Article
- Imaging findings of diabetic complications from head to toe: a comprehensive radiologic review.Japanese journal of radiology · 2026Review
- Development of a Donor-Based Predictive Model for Pancreas Non-Utilization Among Deceased Donor Transplants in the US.Clinical transplantation · 2026Article
- Development and validation of a clinical prediction model for fatty pancreas disease: from CT-based indicators to an easy-to-use prediction application.Nutrition journal · 2026Article
- Construction of a nomogram for hypertriglyceridemic severe acute pancreatitis that includes metabolic indexes.Lipids in health and disease · 2025Article
- Significance of Pancreatic Steatosis as a Predictor of New-Onset Diabetes Mellitus Following Pancreatectomy.Pancreas · 2025Article
- Pancreatic changes in patients with visceral fat obesity: an evaluation with contrast-enhanced dual-energy computed tomography with automated three-dimensional volumetry.La Radiologia medica · 2025Article
- Ultrasound innovations in abdominal radiology: techniques and clinical applications in pediatric imaging.Abdominal radiology (New York) · 2025Review
- The association between pancreatic diseases and pancreatic fat content: a cross-sectional study from the UK Biobank.Frontiers in endocrinology · 2025Article
- Evaluation of pancreatic iodine uptake and related influential factors in multiphase dual-energy CT.European radiology · 2024Article
- Non-invasive diagnosis of pancreatic steatosis with ultrasound images using deep learning network.Heliyon · 2024Article
- Effect of uric acid on lipid metabolism assessed via restricted cubic splines: A new insight.Heliyon · 2024Article
- Developmental programming: Testosterone excess masculinizes female pancreatic transcriptome and function in sheep.Molecular and cellular endocrinology · 2024Article
37 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
After the first description of fatty pancreas in 1933, the effects of pancreatic steatosis have been poorly investigated, compared with that of the liver. However, the interest of research is increasing. Fat accumulation, associated with obesity and the metabolic syndrome (MetS), has been defined as "fatty infiltration" or "nonalcoholic fatty pancreas disease" (NAFPD). The term "fatty replacement" describes a distinct phenomenon characterized by death of acinar cells and replacement by adipose tissue. Risk factors for developing NAFPD include obesity, increasing age, male sex, hypertension, dyslipidemia, alcohol and hyperferritinemia. Increasing evidence support the role of pancreatic fat in the development of type 2 diabetes mellitus, MetS, atherosclerosis, severe acute pancreatitis and even pancreatic cancer. Evidence exists that fatty pancreas could be used as the initial indicator of "ectopic fat deposition", which is a key element of nonalcoholic fatty liver disease and/or MetS. Moreover, in patients with fatty pancreas, pancreaticoduodenectomy is associated with an increased risk of intraoperative blood loss and post-operative pancreatic fistula.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.