ArticleBone & joint research2016
Pharmacokinetics of gentamicin eluted from a regenerating bone graft substitute: In vitro and clinical release studies.
Article in Bone & joint research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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Who cites it
59 citing papers in PubMed, 92 citations in OpenAlex.
- Trial
- Translation-driven design: development of an antibiotic-loaded hydrogel for the management of orthopaedic device-related infection.Bioactive materials · 2026Article
- Short or Long Antibiotic Regimens in Orthopedics.The New England journal of medicine · 2026Article
- Intramedullary nailing with absorbable antibiotic-eluting ceramic for fracture-related infection prophylaxis in high-risk open fractures: a case series and technique.OTA international : the open access journal of orthopaedic trauma · 2026Article
- A Pre-Set Calcium Sulfate/Hydroxyapatite Biomaterial as an Antibiotic-Eluting Bone Extender and a Carrier for BMP-2: A Pilot Study in a Rabbit Posterolateral Spinal Fusion Model.Journal of functional biomaterials · 2026Article
- Intramedullary nailing with an absorbable antibiotic bone graft substitute in fracture-related infections and osteomyelitis: a case series.OTA international : the open access journal of orthopaedic trauma · 2026Article
- CaO-SiOMaterials (Basel, Switzerland) · 2026Article
- Safety of locally applied antibiotics in orthopaedic trauma surgery: descriptive results from a prospective cohort study.Journal of bone and joint infection · 2026Article
- Staged Management of Bone Defects in Chronic Osteomyelitis and Nonunions Using Antibiotic-Loaded Calcium Sulphate-Hydroxyapatite: A Multicenter Retrospective Analysis of 101 Cases.Therapeutics and clinical risk management · 2026Article
- Clinical and functional outcomes of the silo technique in the management of diabetic calcaneal osteomyelitis.Cardiovascular diabetology. Endocrinology reports · 2025Article
- Managing Nonunions and Fracture-Related Infections-A Quarter Century of Knowledge, and Still Curious: A Narrative Review.Journal of clinical medicine · 2025Review
- A Scoping Review of CERAMENT™ Applications in Orthopedic Surgery.Journal of clinical medicine · 2025Review
- Current Concepts of Local Antibiotic Delivery in Bone and Joint Infections-A Narrative Review of Techniques and Clinical Experiences.Microorganisms · 2025Review
- Antibiofilm Activity of a Novel Calcium Phosphate Cement Doped with Two Antibiotics.Journal of functional biomaterials · 2025Article
- Clinical practice guidelines for antimicrobial-loaded cements and beads in orthopedic trauma and arthroplasty.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2024Review
- The Efficacy of Calcium Sulfate/Hydroxyapatite (CaS/HA) Gentamicin in Osteomyelitis Treatment: A Case Series.Antibiotics (Basel, Switzerland) · 2024Article
- The role of implant retention and conservative management in the management of fracture-related infection.Journal of orthopaedics · 2024Article
- A Review of Phage Therapy for Bone and Joint Infections.Methods in molecular biology (Clifton, N.J.) · 2024Review
- Current application and future perspectives of antimicrobial degradable bone substitutes for chronic osteomyelitis.Frontiers in bioengineering and biotechnology · 2024Review
- The benefit of antibiotic-combined Mg-hydroxyapatite bone graft substitute over autologous bone for surgical site infection prevention in posterolateral spinal fusion: a retrospective cohort study.Annals of medicine and surgery (2012) · 2023Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesDeep bone and joint infections (DBJI) are directly intertwined with health, demographic change towards an elderly population, and wellbeing.The elderly human population is more prone to acquire infections, and the consequences such as pain, reduced quality of life, morbidity, absence from work and premature retirement due to disability place significant burdens on already strained healthcare systems and societal budgets.DBJIs are less responsive to systemic antibiotics because of poor vascular perfusion in necrotic bone, large bone defects and persistent biofilm-based infection. Emerging bacterial resistance poses a major threat and new innovative treatment modalities are urgently needed to curb its current trajectory. MATERIALS AND
methodsWe present a new biphasic ceramic bone substitute consisting of hydroxyapatite and calcium sulphate for local antibiotic delivery in combination with bone regeneration. Gentamicin release was measured in four setups: 1) in vitro elution in Ringer's solution; 2) local elution in patients treated for trochanteric hip fractures or uncemented hip revisions; 3) local elution in patients treated with a bone tumour resection; and 4) local elution in patients treated surgically for chronic corticomedullary osteomyelitis.
resultsThe release pattern in vitro was comparable with the obtained release in the patient studies. No recurrence was detected in the osteomyelitis group at latest follow-up (minimum 1.5 years).
conclusionsThis new biphasic bone substitute containing antibiotics provides safe prevention of bone infections in a range of clinical situations. The in vitro test method predicts the in vivo performance and makes it a reliable tool in the development of future antibiotic-eluting bone-regenerating materials.Cite this article: M. Stravinskas, P. Horstmann, J. Ferguson, W. Hettwer, M. Nilsson, S. Tarasevicius, M. M. Petersen, M. A. McNally, L. Lidgren. Pharmacokinetics of gentamicin eluted from a regenerating bone graft substitute: In vitro and clinical release studies. Bone Joint Res 2016;5:427-435. DOI: 10.1302/2046-3758.59.BJR-2016-0108.R1.
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