ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2017
The Relationship Between Cognitive Functioning and the JNC-8 Guidelines for Hypertension in Older Adults.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- Sex Differences in the Association of Simultaneous Decline in Blood Pressure and Decline in Cognition during Aging.Annals of neurology · 2026Article
- Immune system activation and cognitive impairment in arterial hypertension.American journal of physiology. Cell physiology · 2024Review
- The Role of Hypertension in Cognitive Dysfunction.Journal of clinical medicine · 2024Review
- Hypertension, Neurodegeneration, and Cognitive Decline.Hypertension (Dallas, Tex. : 1979) · 2024Review
- Article
- The Relation Between Arterial Hypertension and Cognitive Impairment: A Literature Review.Cureus · 2024Review
- Hypertension and cognitive dysfunction: a narrative review.Journal of Yeungnam medical science · 2023Article
- Soluble and insoluble protein aggregates, endoplasmic reticulum stress, and vascular dysfunction in Alzheimer's disease and cardiovascular diseases.GeroScience · 2023Review
- Factors affecting self-care among community-dwelling hypertensive older adults: A cross-sectional study.Nursing open · 2023Article
- Effects of intensive vs. standard blood pressure control on cognitive function:Frontiers in neurology · 2023Article
- Heart health meets cognitive health: evidence on the role of blood pressure.The Lancet. Neurology · 2021Review
- Nocturnal blood pressure rise as a predictor of cognitive impairment among the elderly: a retrospective cohort study.BMC geriatrics · 2021Article
- Physical Activity in Early- and Mid-Adulthood Are Independently Associated With Longitudinal Memory Trajectories in Later Life.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- Effects of Blood Pressure on Cognitive Performance in Aging: A Systematic Review.Brain sciences · 2020Review
- Effects of Blood Pressure on Cognitive Performance: A Systematic Review.Journal of clinical medicine · 2019Article
- Neurovascular and Cognitive Dysfunction in Hypertension.Circulation research · 2019Review
- Association of JNC-8 and SPRINT Systolic Blood Pressure Levels With Cognitive Function and Related Racial Disparity.JAMA neurology · 2017Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundGuidelines for hypertension treatment by the Eighth Joint National Committee (JNC-8) in 2014 recommended a target systolic blood pressure (BP) of <150/<90 mmHg in persons older than 60 years, in contrast to the 2003 JNC-7 recommendations of systolic BP <140 mmHg. This study evaluated the implications of raising the BP target on cognitive functioning and conversion from normal cognition to mild cognitive impairment (MCI).
methodsThis was a longitudinal study of individuals older than 60 years enrolled in the NIH-NIA Alzheimer's Disease Centers. All had normal cognition at baseline. 453 participants were taking BP medications and had readings of <140/<90 mmHg at four annual visits (reference group). Two other groups consisted of participants with either systolic BP of 140-149 mmHg (n = 112) or ≥150 mmHg (n = 280) on three or four annual visits.
resultsCompared with the reference and the 140-149 mmHg groups, those with BP ≥150 mmHg exhibited poorer cognitive status by Year 4 on the Mini-Mental State Exam, and they had a higher risk of conversion to MCI. The 140-149 mmHg exhibited poorer performance than the reference group on domains assessing attention and executive functioning. In contrast, their performance was not significantly different from those with BP ≥150 mmHg.
conclusionsPersons with BP ≥150 mmHg show a faster global cognitive decline and transition to MCI than those with lower BP readings. However, the poor cognitive performance in the attention and executive functioning domains for the 140-149 mmHg group indicates the need for further research evaluating the newer recommended cutoff.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.