ArticleCirculation2016
Genetic and Pharmacologic Inhibition of the Chemokine Receptor CXCR2 Prevents Experimental Hypertension and Vascular Dysfunction.
Open access · greenAbstract read
In one paragraph
Article in Circulation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.
0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed
10.4field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
67 citing papers in PubMed, 114 citations in OpenAlex.
- IL-1β-mediated interaction between Müller cells and microglia through CXCL1/5-CXCR2 aggravates visual dysfunction in experimental glaucoma.Journal of neuroinflammation · 2026Article
- UBA1 promotes cardiac hypertrophy by suppressing autophagy via targeting ATG5 for ubiquitination.Cell communication and signaling : CCS · 2026Article
- Sodium-Glucose Cotransporter 2 Inhibitor Ameliorate Angiotensin II-Induced Hypertension and Vascular Injury by Upregulating FGF21.Inflammation · 2025Article
- Chemokine receptors in vascular biology: a review of current evidence, implications, and therapeutic targets for hypertension.Clinical science (London, England : 1979) · 2025Review
- CaInflammation and regeneration · 2024Review
- ACE2 alleviates sepsis-induced cardiomyopathy through inhibiting M1 macrophage via NF-κB/STAT1 signals.Cell biology and toxicology · 2024Article
- Anti-CTLA-4 m2a Antibody Exacerbates Cardiac Injury in Experimental Autoimmune Myocarditis Mice By Promoting Ccl5-Neutrophil Infiltration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Immune and inflammatory mechanisms in hypertension.Nature reviews. Cardiology · 2024Review
- Senescence-associated secretory phenotype (SASP) and uterine fibroids: Association with PD-L1 activation and collagen deposition.Ageing research reviews · 2024Review
- Causal role of immune cells in hypertension: a bidirectional Mendelian randomization study.Frontiers in cardiovascular medicine · 2024Article
- CD11b mediates hypertensive cardiac remodeling by regulating macrophage infiltration and polarization.Journal of advanced research · 2024Article
- CD1d-Dependent Natural Killer T Cells Mediate Hypertension and Vascular Injury Through Interleukin-17A.Journal of the American Heart Association · 2023Article
- The chemokines CXCL8 and CXCL12: molecular and functional properties, role in disease and efforts towards pharmacological intervention.Cellular & molecular immunology · 2023Review
- Responses Triggered by the Immune System in Hypertensive Conditions and Repercussions on Target Organ Damage: A Review.Current cardiology reviews · 2023Review
- The Potential Importance of CXCL1 in the Physiological State and in Noncancer Diseases of the Cardiovascular System, Respiratory System and Skin.International journal of molecular sciences · 2022Review
- Peroxisome Proliferator-Activated Receptor α Attenuates Hypertensive Vascular Remodeling by Protecting Vascular Smooth Muscle Cells from Angiotensin II-Induced ROS Production.Antioxidants (Basel, Switzerland) · 2022Article
- Blocking VCAM-1 Prevents Angiotensin II-Induced Hypertension and Vascular Remodeling in Mice.Frontiers in pharmacology · 2022Article
- Farrerol prevents Angiotensin II-induced cardiac remodelingFrontiers in pharmacology · 2022Article
- Blocking VCAM-1 ameliorates hypertensive cardiac remodeling by impeding macrophage infiltration.Frontiers in pharmacology · 2022Article
- Association between high-mobility group box 2 and subclinical hypertension-mediated organ damage in young adults.Therapeutic advances in chronic disease · 2022Article
7 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
12 authors at 5 institutions in 3 countries.
Lei WangFrom Department of Cardiology, Institute of Cardiovascular Diseases, First Affiliated Hospital of Dalian Medical University, Dalian, China (L.W., X.-C.Z., Y.Z.Z., Y.-L.X., H.-H.L.); Beijing Anzhen Hospital, Key Laboratory of Remodeling-Related Cardiovascular Diseases, Capital Medical University, Beijing, China (W.C., J.D.); Tianjin Key Laboratory of Cardiovascular Remodeling and Target Organ Injury, Pingjin Hospital Heart Center, Tianjin, China (Y.-Q.M., X.Z.); Department of Vascular Surgery, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China (H.-L.R.); Department of Pharmacology and Toxicology, University of Graz, Graz, Austria (J.F.); Cardiovascular Division, University of Minnesota, Minneapolis, MN (Y.C.); and Department of Nutrition and Food Hygiene, School of Public Health, Advanced Institute of Medical Sciences, Dalian Medical University, Dalian, China (H.-H.L.).
Xue-Chen ZhaoFrom Department of Cardiology, Institute of Cardiovascular Diseases, First Affiliated Hospital of Dalian Medical University, Dalian, China (L.W., X.-C.Z., Y.Z.Z., Y.-L.X., H.-H.L.); Beijing Anzhen Hospital, Key Laboratory of Remodeling-Related Cardiovascular Diseases, Capital Medical University, Beijing, China (W.C., J.D.); Tianjin Key Laboratory of Cardiovascular Remodeling and Target Organ Injury, Pingjin Hospital Heart Center, Tianjin, China (Y.-Q.M., X.Z.); Department of Vascular Surgery, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China (H.-L.R.); Department of Pharmacology and Toxicology, University of Graz, Graz, Austria (J.F.); Cardiovascular Division, University of Minnesota, Minneapolis, MN (Y.C.); and Department of Nutrition and Food Hygiene, School of Public Health, Advanced Institute of Medical Sciences, Dalian Medical University, Dalian, China (H.-H.L.).
Wei CuiFrom Department of Cardiology, Institute of Cardiovascular Diseases, First Affiliated Hospital of Dalian Medical University, Dalian, China (L.W., X.-C.Z., Y.Z.Z., Y.-L.X., H.-H.L.); Beijing Anzhen Hospital, Key Laboratory of Remodeling-Related Cardiovascular Diseases, Capital Medical University, Beijing, China (W.C., J.D.); Tianjin Key Laboratory of Cardiovascular Remodeling and Target Organ Injury, Pingjin Hospital Heart Center, Tianjin, China (Y.-Q.M., X.Z.); Department of Vascular Surgery, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China (H.-L.R.); Department of Pharmacology and Toxicology, University of Graz, Graz, Austria (J.F.); Cardiovascular Division, University of Minnesota, Minneapolis, MN (Y.C.); and Department of Nutrition and Food Hygiene, School of Public Health, Advanced Institute of Medical Sciences, Dalian Medical University, Dalian, China (H.-H.L.).
Yong-Qiang MaFrom Department of Cardiology, Institute of Cardiovascular Diseases, First Affiliated Hospital of Dalian Medical University, Dalian, China (L.W., X.-C.Z., Y.Z.Z., Y.-L.X., H.-H.L.); Beijing Anzhen Hospital, Key Laboratory of Remodeling-Related Cardiovascular Diseases, Capital Medical University, Beijing, China (W.C., J.D.); Tianjin Key Laboratory of Cardiovascular Remodeling and Target Organ Injury, Pingjin Hospital Heart Center, Tianjin, China (Y.-Q.M., X.Z.); Department of Vascular Surgery, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China (H.-L.R.); Department of Pharmacology and Toxicology, University of Graz, Graz, Austria (J.F.); Cardiovascular Division, University of Minnesota, Minneapolis, MN (Y.C.); and Department of Nutrition and Food Hygiene, School of Public Health, Advanced Institute of Medical Sciences, Dalian Medical University, Dalian, China (H.-H.L.).
Hua-Liang RenFrom Department of Cardiology, Institute of Cardiovascular Diseases, First Affiliated Hospital of Dalian Medical University, Dalian, China (L.W., X.-C.Z., Y.Z.Z., Y.-L.X., H.-H.L.); Beijing Anzhen Hospital, Key Laboratory of Remodeling-Related Cardiovascular Diseases, Capital Medical University, Beijing, China (W.C., J.D.); Tianjin Key Laboratory of Cardiovascular Remodeling and Target Organ Injury, Pingjin Hospital Heart Center, Tianjin, China (Y.-Q.M., X.Z.); Department of Vascular Surgery, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China (H.-L.R.); Department of Pharmacology and Toxicology, University of Graz, Graz, Austria (J.F.); Cardiovascular Division, University of Minnesota, Minneapolis, MN (Y.C.); and Department of Nutrition and Food Hygiene, School of Public Health, Advanced Institute of Medical Sciences, Dalian Medical University, Dalian, China (H.-H.L.).
Xin ZhouFrom Department of Cardiology, Institute of Cardiovascular Diseases, First Affiliated Hospital of Dalian Medical University, Dalian, China (L.W., X.-C.Z., Y.Z.Z., Y.-L.X., H.-H.L.); Beijing Anzhen Hospital, Key Laboratory of Remodeling-Related Cardiovascular Diseases, Capital Medical University, Beijing, China (W.C., J.D.); Tianjin Key Laboratory of Cardiovascular Remodeling and Target Organ Injury, Pingjin Hospital Heart Center, Tianjin, China (Y.-Q.M., X.Z.); Department of Vascular Surgery, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China (H.-L.R.); Department of Pharmacology and Toxicology, University of Graz, Graz, Austria (J.F.); Cardiovascular Division, University of Minnesota, Minneapolis, MN (Y.C.); and Department of Nutrition and Food Hygiene, School of Public Health, Advanced Institute of Medical Sciences, Dalian Medical University, Dalian, China (H.-H.L.).
John FassettFrom Department of Cardiology, Institute of Cardiovascular Diseases, First Affiliated Hospital of Dalian Medical University, Dalian, China (L.W., X.-C.Z., Y.Z.Z., Y.-L.X., H.-H.L.); Beijing Anzhen Hospital, Key Laboratory of Remodeling-Related Cardiovascular Diseases, Capital Medical University, Beijing, China (W.C., J.D.); Tianjin Key Laboratory of Cardiovascular Remodeling and Target Organ Injury, Pingjin Hospital Heart Center, Tianjin, China (Y.-Q.M., X.Z.); Department of Vascular Surgery, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China (H.-L.R.); Department of Pharmacology and Toxicology, University of Graz, Graz, Austria (J.F.); Cardiovascular Division, University of Minnesota, Minneapolis, MN (Y.C.); and Department of Nutrition and Food Hygiene, School of Public Health, Advanced Institute of Medical Sciences, Dalian Medical University, Dalian, China (H.-H.L.).
Yan-Zong YangFrom Department of Cardiology, Institute of Cardiovascular Diseases, First Affiliated Hospital of Dalian Medical University, Dalian, China (L.W., X.-C.Z., Y.Z.Z., Y.-L.X., H.-H.L.); Beijing Anzhen Hospital, Key Laboratory of Remodeling-Related Cardiovascular Diseases, Capital Medical University, Beijing, China (W.C., J.D.); Tianjin Key Laboratory of Cardiovascular Remodeling and Target Organ Injury, Pingjin Hospital Heart Center, Tianjin, China (Y.-Q.M., X.Z.); Department of Vascular Surgery, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China (H.-L.R.); Department of Pharmacology and Toxicology, University of Graz, Graz, Austria (J.F.); Cardiovascular Division, University of Minnesota, Minneapolis, MN (Y.C.); and Department of Nutrition and Food Hygiene, School of Public Health, Advanced Institute of Medical Sciences, Dalian Medical University, Dalian, China (H.-H.L.).
Yingjie ChenFrom Department of Cardiology, Institute of Cardiovascular Diseases, First Affiliated Hospital of Dalian Medical University, Dalian, China (L.W., X.-C.Z., Y.Z.Z., Y.-L.X., H.-H.L.); Beijing Anzhen Hospital, Key Laboratory of Remodeling-Related Cardiovascular Diseases, Capital Medical University, Beijing, China (W.C., J.D.); Tianjin Key Laboratory of Cardiovascular Remodeling and Target Organ Injury, Pingjin Hospital Heart Center, Tianjin, China (Y.-Q.M., X.Z.); Department of Vascular Surgery, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China (H.-L.R.); Department of Pharmacology and Toxicology, University of Graz, Graz, Austria (J.F.); Cardiovascular Division, University of Minnesota, Minneapolis, MN (Y.C.); and Department of Nutrition and Food Hygiene, School of Public Health, Advanced Institute of Medical Sciences, Dalian Medical University, Dalian, China (H.-H.L.).
Yun-Long XiaFrom Department of Cardiology, Institute of Cardiovascular Diseases, First Affiliated Hospital of Dalian Medical University, Dalian, China (L.W., X.-C.Z., Y.Z.Z., Y.-L.X., H.-H.L.); Beijing Anzhen Hospital, Key Laboratory of Remodeling-Related Cardiovascular Diseases, Capital Medical University, Beijing, China (W.C., J.D.); Tianjin Key Laboratory of Cardiovascular Remodeling and Target Organ Injury, Pingjin Hospital Heart Center, Tianjin, China (Y.-Q.M., X.Z.); Department of Vascular Surgery, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China (H.-L.R.); Department of Pharmacology and Toxicology, University of Graz, Graz, Austria (J.F.); Cardiovascular Division, University of Minnesota, Minneapolis, MN (Y.C.); and Department of Nutrition and Food Hygiene, School of Public Health, Advanced Institute of Medical Sciences, Dalian Medical University, Dalian, China (H.-H.L.).
Jie DuFrom Department of Cardiology, Institute of Cardiovascular Diseases, First Affiliated Hospital of Dalian Medical University, Dalian, China (L.W., X.-C.Z., Y.Z.Z., Y.-L.X., H.-H.L.); Beijing Anzhen Hospital, Key Laboratory of Remodeling-Related Cardiovascular Diseases, Capital Medical University, Beijing, China (W.C., J.D.); Tianjin Key Laboratory of Cardiovascular Remodeling and Target Organ Injury, Pingjin Hospital Heart Center, Tianjin, China (Y.-Q.M., X.Z.); Department of Vascular Surgery, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China (H.-L.R.); Department of Pharmacology and Toxicology, University of Graz, Graz, Austria (J.F.); Cardiovascular Division, University of Minnesota, Minneapolis, MN (Y.C.); and Department of Nutrition and Food Hygiene, School of Public Health, Advanced Institute of Medical Sciences, Dalian Medical University, Dalian, China (H.-H.L.).
Hui-Hua LiFrom Department of Cardiology, Institute of Cardiovascular Diseases, First Affiliated Hospital of Dalian Medical University, Dalian, China (L.W., X.-C.Z., Y.Z.Z., Y.-L.X., H.-H.L.); Beijing Anzhen Hospital, Key Laboratory of Remodeling-Related Cardiovascular Diseases, Capital Medical University, Beijing, China (W.C., J.D.); Tianjin Key Laboratory of Cardiovascular Remodeling and Target Organ Injury, Pingjin Hospital Heart Center, Tianjin, China (Y.-Q.M., X.Z.); Department of Vascular Surgery, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China (H.-L.R.); Department of Pharmacology and Toxicology, University of Graz, Graz, Austria (J.F.); Cardiovascular Division, University of Minnesota, Minneapolis, MN (Y.C.); and Department of Nutrition and Food Hygiene, School of Public Health, Advanced Institute of Medical Sciences, Dalian Medical University, Dalian, China (H.-H.L.). hhli1935@aliyun.com yunlong_xia@126.com.
Beijing Chao-Yang Hospital · CNBeijing Anzhen Hospital · CNCapital Medical University · CNPingjin Hospital · CNUniversity of Minnesota · US
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe recruitment of leukocytes to the vascular wall is a key step in hypertension development. Chemokine receptor CXCR2 mediates inflammatory cell chemotaxis in several diseases. However, the role of CXCR2 in hypertension development and the underlying mechanisms remain unknown.
methodsAngiotensin II (490 ng·kg
resultsAngiotensin II significantly upregulated the expression of CXCR2 mRNA and protein and increased the number of CD45
conclusionsInfiltration of CXCR2
Indexed as
Angiotensin IIAnimalsDisease Models, AnimalHypertensionMaleMiceMice, KnockoutReceptors, Interleukin-8BUp-RegulationVascular RemodelingAngiotensin IIReceptors, Interleukin-8BchemoreceptorCXCR2hypertensioninflammationoxidant stress
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.