ArticleScientific reports2016
In vivo formation of natural HgSe nanoparticles in the liver and brain of pilot whales.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 112 citations in OpenAlex.
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- Evaluation of extraction capabilities of protease, proteinase K, and TMAH for nanoparticle characterization in biological CRMs by spICP-MS.Analytical and bioanalytical chemistry · 2026Article
- In Vivo Bioimaging of Mercury Sulfide Nanoparticles Dissolution in the Gut Environment of Zooplankton.ACS nano · 2026Article
- Development and validation of a non-chromatographic method for mercury and methylmercury in finfish using thermal decomposition gold amalgamation atomic absorption spectrophotometry (TDA-AAS) and salting-out assisted liquid-liquid extraction (SALLE).Analytical and bioanalytical chemistry · 2025Article
- Mediterranean Marine Mammals: Possible Future Trends and Threats Due to Mercury Contamination and Interaction with Other Environmental Stressors.Animals : an open access journal from MDPI · 2024Review
- Tissue Distribution and Toxicological Risk Assessment of Mercury and Other Elements in Northern Populations of Wolverine (Gulo gulo).Archives of environmental contamination and toxicology · 2024Article
- Intestinal microbiota protects against methylmercury-induced neurotoxicity.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2024Review
- Mercury and selenium distribution in human brain tissue using synchrotron micro-X-ray fluorescence.Metallomics : integrated biometal science · 2024Article
- Nanoparticles as a younger member of the trace element species family - a food perspective.Analytical and bioanalytical chemistry · 2024Article
- Article
- Basic and advanced spectrometric methods for complete nanoparticles characterization in bio/eco systems: current status and future prospects.Analytical and bioanalytical chemistry · 2023Review
- Quantitative mapping of mercury and selenium in mushroom fruit bodies with laser ablation-inductively coupled plasma-mass spectrometry.Analytical and bioanalytical chemistry · 2022Article
- Analytical Methods for Nanomaterial Determination in Biological Matrices.Methods and protocols · 2022Review
- Internal Dynamics and Metabolism of Mercury in Biota: A Review of Insights from Mercury Stable Isotopes.Environmental science & technology · 2022Review
- Determination of metallic nanoparticles in biological samples by single particle ICP-MS: a systematic review from sample collection to analysis.Environmental science. Nano · 2022Review
- Distribution of Pb and Se in mouse brain following subchronic Pb exposure by using synchrotron X-ray fluorescence.Neurotoxicology · 2022Article
- Mercury and Selenium Localization in the Cerebrum, Cerebellum, Liver, and Kidney of a Minamata Disease Case.Acta histochemica et cytochemica · 2020Article
- Mercury in Ringed Seals (Pusa hispida) from the Canadian Arctic in Relation to Time and Climate Parameters.Environmental toxicology and chemistry · 2020Article
- Constraining Atmospheric Selenium Emissions Using Observations, Global Modeling, and Bayesian Inference.Environmental science & technology · 2020Article
- Ultra-High Resolution Elemental/Isotopic Mass Spectrometry (m/Δm > 1,000,000): Coupling of the Liquid Sampling-Atmospheric Pressure Glow Discharge with an Orbitrap Mass Spectrometer for Applications in Biological Chemistry and Environmental Analysis.Journal of the American Society for Mass Spectrometry · 2019Article
Corrections and comments
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Authors and funding
14 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To understand the biochemistry of methylmercury (MeHg) that leads to the formation of mercury-selenium (Hg-Se) clusters is a long outstanding challenge that promises to deepen our knowledge of MeHg detoxification and the role Se plays in this process. Here, we show that mercury selenide (HgSe) nanoparticles in the liver and brain of long-finned pilot whales are attached to Se-rich structures and possibly act as a nucleation point for the formation of large Se-Hg clusters, which can grow with age to over 5 μm in size. The detoxification mechanism is fully developed from the early age of the animals, with particulate Hg found already in juvenile tissues. As a consequence of MeHg detoxification, Se-methionine, the selenium pool in the system is depleted in the efforts to maintain essential levels of Se-cysteine. This study provides evidence of so far unreported depletion of the bioavailable Se pool, a plausible driving mechanism of demonstrated neurotoxic effects of MeHg in the organism affected by its high dietary intake.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.