ArticlePlant physiology2016
Ethylene-Regulated Glutamate Dehydrogenase Fine-Tunes Metabolism during Anoxia-Reoxygenation.
Article in Plant physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 68 citations in OpenAlex.
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- Mangrove-Derived Endophytic Bacteria Enhance Growth, Yield, and Stress Resilience in Rice.International journal of molecular sciences · 2025Article
- A large-scale gene co-expression network analysis reveals Glutamate Dehydrogenase 2 (GhGDH2_D03) as a hub regulator of salt and salt-alkali tolerance in cotton.Plant molecular biology · 2025Article
- The phytohormone brassinosteroid (BR) promotes early seedling development via auxin signaling pathway in rapeseed.BMC plant biology · 2025Article
- Plant Life with and without Oxygen: A Metabolomics Approach.International journal of molecular sciences · 2023Review
- Submergence Stress Alters the Expression of Clock Genes and Configures New Zeniths and Expression of Outputs inInternational journal of molecular sciences · 2023Article
- Multi-stress resilience in plants recovering from submergence.Plant biotechnology journal · 2023Review
- Unraveling the mystery of canopy dieback caused by citrus disease Huanglongbing and its link to hypoxia stress.Frontiers in plant science · 2023Article
- Salt Stress Tolerance inPlants (Basel, Switzerland) · 2022Article
- The Role of Phytohormones in Plant Response to Flooding.International journal of molecular sciences · 2022Review
- Ethylene modulates translation dynamics inScience advances · 2022Article
- GWAS on multiple traits identifies mitochondrial ACONITASE3 as important for acclimation to submergence stress.Plant physiology · 2022Article
- Try or Die: Dynamics of Plant Respiration and How to Survive Low Oxygen Conditions.Plants (Basel, Switzerland) · 2022Review
- Cloning and Bioinformatics Analysis ofFrontiers in plant science · 2022Article
- Calcium peroxide alleviates the waterlogging stress of rapeseed by improving root growth status in a rice-rape rotation field.Frontiers in plant science · 2022Article
- Drought and Subsequent Soil Flooding Affect the Growth and Metabolism of Savoy Cabbage.International journal of molecular sciences · 2021Article
- Iron insufficiency in floral buds impairs pollen development by disrupting tapetum function.The Plant journal : for cell and molecular biology · 2021Article
- Understanding a Mechanistic Basis of ABA Involvement in Plant Adaptation to Soil Flooding: The Current Standing.Plants (Basel, Switzerland) · 2021Review
- The role of ethylene in metabolic acclimations to low oxygen.The New phytologist · 2021Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ethylene is an essential hormone in plants that is involved in low-oxygen and reoxygenation responses. As a key transcription factor in ethylene signaling, ETHYLENE INSENSITIVE3 (EIN3) activates targets that trigger various responses. However, most of these targets are still poorly characterized. Through analyses of our microarray data and the published Arabidopsis (Arabidopsis thaliana) EIN3 chromatin immunoprecipitation sequencing data set, we inferred the putative targets of EIN3 during anoxia-reoxygenation. Among them, GDH2, which encodes one subunit of glutamate dehydrogenase (GDH), was chosen for further studies for its role in tricarboxylic acid cycle replenishment. We demonstrated that both GDH1 and GDH2 are induced during anoxia and reoxygenation and that this induction is mediated via ethylene signaling. In addition, the results of enzymatic assays showed that the level of GDH during anoxia-reoxygenation decreased in the ethylene-insensitive mutants ein2-5 and ein3eil1 Global metabolite analysis indicated that the deamination activity of GDH might regenerate 2-oxoglutarate, which is a cosubstrate that facilitates the breakdown of alanine by alanine aminotransferase when reoxygenation occurs. Moreover, ineffective tricarboxylic acid cycle replenishment, disturbed carbohydrate metabolism, reduced phytosterol biosynthesis, and delayed energy regeneration were found in gdh1gdh2 and ethylene mutants during reoxygenation. Taken together, these data illustrate the essential role of EIN3-regulated GDH activity in metabolic adjustment during anoxia-reoxygenation.
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