Evidence map›Paper›PMID 27677924›Full record

ArticleBritish journal of pharmacology2016

Selective activation of vascular K

Xuan Zhang, Hailong An, Junwei Li, Yuanyuan Zhang, Yang Liu, Zhanfeng Jia, Wei Zhang, Li Chu, Hailin Zhang

Open access · bronzeAbstract read
In one paragraph

Article in British journal of pharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Activation of KCNQ4 as a Therapeutic Strategy to Treat Hearing Loss.International journal of molecular sciences · 2021
    Review
  7. Kv7 Channels in Lung Diseases.Frontiers in physiology · 2020
    Review
  8. Article
  9. M-type KBritish journal of pharmacology · 2018
    Review
  10. Selective targeting of M-type potassium KBritish journal of pharmacology · 2017
    Article
  11. Article
  12. Selective Modulation of KFrontiers in cellular neuroscience · 2017
    Article
  13. Selective activation of vascular KBritish journal of pharmacology · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Xuan ZhangDepartment of Pharmacology, Hebei Medical University, Shijiazhuang, China.
Hailong AnKey Laboratory of Molecular Biophysics, Hebei Province; Institute of Biophysics, School of Sciences, Hebei University of Technology, Tianjin, China.
Junwei LiKey Laboratory of Molecular Biophysics, Hebei Province; Institute of Biophysics, School of Sciences, Hebei University of Technology, Tianjin, China.
Yuanyuan ZhangDepartment of Pharmacology, Hebei University of Chinese Medicine, Shijiazhuang, China.
Yang LiuDepartment of Pharmacology, Hebei Medical University, Shijiazhuang, China.
Zhanfeng JiaDepartment of Pharmacology, Hebei Medical University, Shijiazhuang, China.
Wei ZhangDepartment of Pharmacology, Institution of Chinese Integrative Medicine, Hebei Medical University, Shijiazhuang, China.
Li ChuDepartment of Pharmacology, Hebei University of Chinese Medicine, Shijiazhuang, China.
Hailin ZhangDepartment of Pharmacology, Hebei Medical University, Shijiazhuang, China.
Hebei University of Chinese Medicine · CNHebei Medical University · CNInstitute of Biophysics · CNInstitute of Molecular Biology and Biophysics · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeK EXPERIMENTAL APPROACH: A perforated whole-cell patch technique was used to record the currents and membrane potential. Homology modelling and a docking technique were used to investigate the interaction between fasudil and the K KEY

resultsFasudil selectively and potently enhanced K CONCLUSIONS AND IMPLICATIONS: These results suggest that fasudil is a selective K

Indexed as

1-(5-Isoquinolinesulfonyl)-2-MethylpiperazineAnimalsAnthracenesCells, CulturedDose-Response Relationship, DrugHEK293 CellsHumansMaleMolecular StructurePotassium Channels, Voltage-GatedRatsRats, Sprague-DawleyStructure-Activity RelationshipVasodilationVasodilator Agents10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone1-(5-Isoquinolinesulfonyl)-2-MethylpiperazineAnthracenesfasudilPotassium Channels, Voltage-GatedVasodilator Agents

Identifiers

PMID27677924
PMCPMC5120158
OpenAlexW2527170411

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.