ArticleSports medicine (Auckland, N.Z.)2017
Training to Fatigue: The Answer for Standardization When Assessing Muscle Hypertrophy?
Article in Sports medicine (Auckland, N.Z.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it, 112 citations in OpenAlex.
- Resistance Training Load Effects on Muscle Hypertrophy and Strength Gain: Systematic Review and Network Meta-analysis.Medicine and science in sports and exercise · 2021Pooled it
- Submaximal low-load resistance exercise with blood flow restriction produces similar results to low-load exercise to failure for muscle size and strength, but not endurance.European journal of applied physiology · 2026Trial
- Milk Protein Glycation Compromises Postprandial Lysine Bioavailability but does not Modulate Postprandial Muscle Protein Synthesis Rates In Vivo in Males: A Double-blind, Randomized Parallel Trial.The Journal of nutrition · 2025Trial
- Immediate effect of ice and dry massage during rest breaks on recovery in MMA fighters : a randomized crossover clinical trial study.Scientific reports · 2025Trial
- Arterial Stiffness and Wave Reflection Responses Following Heavy and Moderate Load Resistance Training Protocols.Journal of clinical hypertension (Greenwich, Conn.) · 2025Trial
- Resistance Training Volume Enhances Muscle Hypertrophy but Not Strength in Trained Men.Medicine and science in sports and exercise · 2019Trial
- Moderately heavy exercise produces lower cardiovascular, RPE, and discomfort compared to lower load exercise with and without blood flow restriction.European journal of applied physiology · 2018Trial
- Effects of In-Season Velocity-Based Resistance Training on Boxing-Specific Performance in Collegiate Boxers: A Companion Report from a Randomized Controlled Trial.Journal of functional morphology and kinesiology · 2026Article
- Rethinking task failure in resistance training research: a framework for submaximal exercise prescription.European journal of applied physiology · 2026Review
- The effects of 6 weeks of high load or low-load blood flow restriction resistance exercise training on motor unit firing rates in males and females.Journal of neurophysiology · 2026Article
- Effects of High-Intensity Resistance Training Volume on Muscle Performance and Blood-derived Markers in Recreationally Trained Subjects.International journal of exercise science · 2026Article
- The interplay between muscle length, range of motion, and exercise selection: a review.Sports medicine international open · 2026Review
- The role of resistance exercise-induced local metabolic stress in mediating systemic health and functional adaptations: could condensed training volume unlock greater benefits beyond time efficiency?Frontiers in physiology · 2025Review
- Study of different acute SIT protocols' impact on 200m sprinters' anaerobic performance.Frontiers in physiology · 2025Article
- The effects of eccentric phase tempo in squats on hypertrophy, strength, and contractile properties of the quadriceps femoris muscle.Frontiers in physiology · 2024Article
- Training in the Initial Range of Motion Promotes Greater Muscle Adaptations Than at Final in the Arm Curl.Sports (Basel, Switzerland) · 2023Article
- Effects of low-load blood flow restriction on the venous system in comparison to traditional low-load and high-load exercises.Frontiers in physiology · 2023Article
- Intensity of effort and momentary failure in resistance training: Are we asking a binary question for a continuous variable?Journal of sport and health science · 2022Article
- Injuries and Strength Training Practices in Collegiate Tennis.Sports (Basel, Switzerland) · 2022Article
- The acute muscular response following a novel form of pulsed direct current stimulation (Neubie) or traditional resistance exercise.Journal of musculoskeletal & neuronal interactions · 2022Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Studies examining resistance training are of importance given that increasing or maintaining muscle mass aids in the prevention or attenuation of chronic disease. Within the literature, it is common practice to administer a set number of target repetitions to be completed by all individuals (i.e. 3 sets of 10) while setting the load relative to each individual's predetermined strength level (usually a one-repetition maximum). This is done under the assumption that all individuals are receiving a similar stimulus upon completing the protocol, but this does not take into account individual variability with regard to how fatiguing the protocol actually is. Another limitation that exists within the current literature is the reporting of exercise volume in absolute or relative terms that are not truly replicable as they are both load-dependent and will differ based on the number of repetitions individuals can complete at a given relative load. Given that the level of fatigue caused by an exercise protocol is a good indicator of its hypertrophic potential, the most appropriate way to ensure all individuals are given a common stimulus is to prescribe exercise to volitional fatigue. While some authors commonly employ this practice, others still prescribe an arbitrary number of repetitions, which may lead to unfair comparisons between exercise protocols. The purpose of this opinion piece is to provide evidence for the need to standardize studies examining muscle hypertrophy. In our opinion, one way in which this can be accomplished is by prescribing all sets to volitional fatigue.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.