Evidence map›Paper›PMID 27677886›Full record

Trial reportMolecular imaging and biology2016

Utility of [

Gina Kavanaugh, Jason Williams, Andrew Scott Morris, Michael L Nickels, Ronald Walker, Norman Koglin, Andrew W Stephens, M Kay Washington, Sunil K Geevarghese, Qi Liu and 3 more

Abstract readClinical Trial
In one paragraph

Trial report in Molecular imaging and biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.

  1. Pooled it
  2. Prospective comparison of (4S)-4-(3-European journal of nuclear medicine and molecular imaging · 2019
    Trial
  3. Review
  4. Review
  5. Compact and cGMP-compliant automated synthesis of [EJNMMI radiopharmacy and chemistry · 2025
    Article
  6. Article
  7. Clinical [Cancers · 2024
    Article
  8. Article
  9. Is System xCancers · 2023
    Review
  10. Simplified and highly-reliable automated production of [EJNMMI radiopharmacy and chemistry · 2023
    Article
  11. Article
  12. Radiosynthesis and Analysis of (S)-4-(3-[Molecular imaging and biology · 2023
    Article
  13. Review
  14. Feasibility of [Tomography (Ann Arbor, Mich.) · 2023
    Article
  15. Review
  16. Radiology · 2022
    Article
  17. Article
  18. First-in-Human PET Imaging and Estimated Radiation Dosimetry of l-[5-Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022
    Article
  19. Article
  20. Robust and Facile Automated Radiosynthesis of [Molecular imaging and biology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Gina KavanaughVanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.
Jason WilliamsVanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.
Andrew Scott MorrisDepartment of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.
Michael L NickelsVanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.
Ronald WalkerDepartment of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.
Norman KoglinPiramal Imaging GmbH, Berlin, Germany.
Andrew W StephensPiramal Imaging GmbH, Berlin, Germany.
M Kay WashingtonDepartment of Pathology, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.
Sunil K GeevargheseDepartment of Surgery, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.
Qi LiuDepartment of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN, 37232, USA.
Dan AyersDepartment of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN, 37232, USA.
Yu ShyrCenter for Quantitative Sciences, Vanderbilt University School of Medicine, Nashville, TN, 37232, USA.
H Charles ManningVanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, 37232, USA. henry.c.manning@vanderbilt.edu.
Vanderbilt University Medical Center · USVanderbilt University · USPiramal (Germany) · DE

Funding

Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MATTHEW J TYSKA · 1995 to 2026
$172.8M
Radiofluorination Equipment for PET Imaging ResearchS10OD019963 · OD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MANNING, HENRY CHARLES · 2016 to 2016
$291k
NCI NIH HHS P30 CA068485NIH HHS S10 OD019963
6 · The paper itself

Abstract

purposeNon-invasive imaging is central to hepatocellular carcinoma (HCC) diagnosis; however, conventional modalities are limited by smaller tumors and other chronic diseases that are often present in patients with HCC, such as cirrhosis. This pilot study evaluated the feasibility of (4S)-4-(3-[ PROCEDURES: x

resultsx

conclusions[

Indexed as

AcetatesAdultAgedAmino Acid Transport System y+Carbon RadioisotopesCarcinoma, HepatocellularFemaleGlutamatesGlutamic AcidHumansLiver NeoplasmsMaleMiddle AgedPositron-Emission TomographyRadiopharmaceuticalsSequence Analysis, RNA4-(3-fluoropropyl)glutamic acidAcetatesAmino Acid Transport System y+Carbon RadioisotopesGlutamatesGlutamic AcidRadiopharmaceuticalsSLC7A11 protein, humanCancer imagingFSPGHCCPET

Identifiers

PMID27677886
PMCPMC5641676
OpenAlexW2527172603

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.