ArticleJournal of feline medicine and surgery2017
Therapeutic effects of an alpha-casozepine and L-tryptophan supplemented diet on fear and anxiety in the cat.
Article in Journal of feline medicine and surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 62 citations in OpenAlex.
- Trial
- Feline chronic diarrhea: causes and nutritional management.Veterinary and animal science · 2026Review
- From functional ingredients to bioactive compounds: a review of their role in commercial pet food.Veterinary research communications · 2026Review
- A Systematic Review of the Sedative, Behavioral, Analgesic and Cardiovascular Effects of Gabapentin in Cats.Veterinary sciences · 2025Review
- Tools for the Approach of Fear, Anxiety, and Stress in the Domestic Feline: An Update.Veterinary medicine international · 2025Review
- Treats containing cannabidiol, L-tryptophan andFrontiers in veterinary science · 2025Article
- Feline Cognition and the Role of Nutrition: An Evolutionary Perspective and Historical Review.Animals : an open access journal from MDPI · 2024Review
- Characteristics of Nutrition and Metabolism in Dogs and Cats.Advances in experimental medicine and biology · 2024Article
- Roles of Nutrients in the Brain Development, Cognitive Function, and Mood of Dogs and Cats.Advances in experimental medicine and biology · 2024Article
- Compound Bacillus alleviates diarrhea by regulating gut microbes, metabolites, and inflammatory responses in pet cats.Animal microbiome · 2023Article
- Fecal Calprotectin Concentrations in Cats with Chronic Enteropathies.Veterinary sciences · 2023Article
- Amino acid nutrition and metabolism in domestic cats and dogs.Journal of animal science and biotechnology · 2023Review
- Dietary Strategies for Relieving Stress in Pet Dogs and Cats.Antioxidants (Basel, Switzerland) · 2023Review
- Feline Stress Management During air Travel: A Multimodal Approach.Journal of feline medicine and surgery · 2023Review
- Human impact on the recent population history of the elusive European wildcat inferred from whole genome data.BMC genomics · 2022Article
- Occurrence and clinical management of urethral obstruction in male cats under primary veterinary care in the United Kingdom in 2016.Journal of veterinary internal medicine · 2022Article
- Dealing With Stress in Cats: What Is New About the Olfactory Strategy?Frontiers in veterinary science · 2022Review
- Prevalence, Risk Factors, Pathophysiology, Potential Biomarkers and Management of Feline Idiopathic Cystitis: An Update Review.Frontiers in veterinary science · 2022Review
- An Interdisciplinary Approach for Compulsive Behavior in Dogs: A Case Report.Frontiers in veterinary science · 2022Article
- Cats at the Vet: The Effect of Alpha-s1 Casozepin.Animals : an open access journal from MDPI · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives This study assessed the anxiolytic effectiveness of a test diet (Royal Canin Feline Calm diet) supplemented with L-tryptophan and alpha-casozepine. Methods Subjects were 24 cats that were classified as mildly or markedly fearful based on the presence of a person in their home room. Three different protocols were used to assess anxiety: (1) evaluation of the response to a human in the cat's home room (home room test); (2) analysis of the response to placement in an empty test room (open-field test); and (3) analysis of the response to an unfamiliar human (human interaction test). All three protocols were first run at baseline, and the results were used to assign the animals to control and test diet groups that showed equivalent fear and anxiety. Both groups were retested on the three protocols after 2 weeks (test 1) and again after 4 weeks (test 2). Results The diet groups differed for two behavioral measures in the open-field test: inactivity duration and inactivity frequency. The control group showed statistically significant increases in inactivity duration between baseline and test 1 and baseline and test 2, while the group fed the test diet showed a marginally not significant decrease in inactivity duration between baseline and test 1 and a not significant decrease for test 2. There was also a significant increase in inactivity frequency between baseline and test 1 in the test diet group and marginally not significant decrease in the control group. There were no differences between groups in the approach of the cats toward people for the home room test and the human interaction test. Conclusions and relevance These results suggest that the test diet reduced the anxiety response to placement in an unfamiliar location, but that fear in the presence of an unfamiliar person was not counteracted by the diet.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.