ArticleBiology letters2016
Food limitation constrains host immune responses to nematode infections.
Article in Biology letters, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Using host species traits to understand the consequences of resource provisioning for host-parasite interactions.The Journal of animal ecology · 2018Pooled it
- Age at First Reproduction Predicts Sex-Specific Parasite Infection Trajectories Through Adulthood.Ecology and evolution · 2026Article
- Food Subsidy Effects on Host Foraging Behavior Shape Host-Macroparasite Infection Dynamics.Ecology and evolution · 2026Article
- Temporal dynamics in gastrointestinal helminth infections of sympatric mouse lemur species (International journal for parasitology. Parasites and wildlife · 2024Article
- Time-energy budgets outperform dynamic body acceleration in predicting daily energy expenditure in kittiwakes, and estimate a very low cost of gliding flight relative to flapping flight.The Journal of experimental biology · 2024Article
- Life-history stage influences immune investment and oxidative stress in response to environmental heterogeneity in Antarctic fur seals.Communications biology · 2024Article
- Complex associations between cancer progression and immune gene expression reveals early influence of transmissible cancer on Tasmanian devils.Frontiers in immunology · 2024Article
- Re-emphasizing mechanism in the community ecology of disease.Functional ecology · 2021Article
- Puumala Virus Variants Circulating in Forests of Ardennes, France: Ten Years of Genetic Evolution.Pathogens (Basel, Switzerland) · 2021Article
- Embracing nature's complexity: Immunoparasitology in the wild.Seminars in immunology · 2021Review
- Effects of an anthropogenic diet on indicators of physiological challenge and immunity of white ibis nestlings raised in captivity.Ecology and evolution · 2020Article
- Individual and environmental determinants of Cuterebra bot fly parasitism in the eastern chipmunk (Tamias striatus).Oecologia · 2020Article
- Geographic variation in baseline innate immune function does not follow variation in aridity along a tropical environmental gradient.Scientific reports · 2020Article
- Immune state is associated with natural dietary variation in wild miceFunctional ecology · 2019Article
- Article
- Reviewing the effects of food provisioning on wildlife immunity.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Review
- Livestock abundance predicts vampire bat demography, immune profiles and bacterial infection risk.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Article
- Anthropogenic resource subsidies and host-parasite dynamics in wildlife.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Article
- Food for contagion: synthesis and future directions for studying host-parasite responses to resource shifts in anthropogenic environments.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Review
- The effects of food and parasitism on reproductive performance of a wild rodent.Ecology and evolution · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Trade-offs in the allocation of finite-energy resources among immunological defences and other physiological processes are believed to influence infection risk and disease severity in food-limited wildlife populations. However, this prediction has received little experimental investigation. Here we test the hypothesis that food limitation impairs the ability of wild field voles (Microtus agrestis) to mount an immune response against parasite infections. We conducted a replicated experiment on vole populations maintained in large outdoor enclosures during boreal winter, using food supplementation and anthelmintic treatment of intestinal nematodes. Innate immune responses against intestinal parasite infections were compared between food-supplemented and non-supplemented voles. Voles with high food availability mounted stronger immune responses against intestinal nematode infections than food-limited voles. No food effects were seen in immune responses to intracellular coccidian parasites, possibly owing to their ability to avoid activation of innate immune pathways. Our findings demonstrate that food availability constrains vole immune responses against nematode infections, and support the concept that spatio-temporal heterogeneity in food availability creates variation in infectious disease susceptibility.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.