ArticleHuman brain mapping2017
Neuroticism modulates brain visuo-vestibular and anxiety systems during a virtual rollercoaster task.
Article in Human brain mapping, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
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Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- Gray matter structures associated with neuroticism: A meta-analysis of whole-brain voxel-based morphometry studies.Human brain mapping · 2021Pooled it
- Vestibular-Visual Reweighting in Persistent Postural-Perceptual Dizziness: A Multilevel Resting-State fMRI Study.Neural plasticity · 2026Article
- Chronic dizziness: neuro-sensitization and psycho-sensitization.Frontiers in integrative neuroscience · 2026Review
- Updated Views on Vestibular Physical Therapy for Patients with Vestibular Disorders.Healthcare (Basel, Switzerland) · 2025Article
- Research Progress on the Potential Pathogenesis of Persistent Postural-Perceptual Dizziness.Brain and behavior · 2025Review
- Modality-specific effects of threat on self-motion perception.BMC biology · 2024Article
- Electroencephalography Spectral-power Volatility Predicts Problem-solving Outcomes.Journal of cognitive neuroscience · 2024Article
- Vestibular dysfunction in Parkinson's disease: a neglected topic.Frontiers in neurology · 2024Review
- Article
- Optimizing vestibular neuritis management with modular strategies.Frontiers in neurology · 2023Article
- A case report of agoraphobia following right parietal lobe surgery: changes in functional and structural connectivities of the multimodal vestibular network.Frontiers in neurology · 2023Article
- Microbiota-ear-brain interaction is associated with generalized anxiety disorder through activation of inflammatory cytokine responses.Frontiers in immunology · 2023Article
- [The comorbid mechanism of vestibular migraine and persistent postural-perceptual dizziness].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2022Article
- Gut Microbiome and Metabolome Changes in Mice With Acute Vestibular Deficit.Frontiers in cellular and infection microbiology · 2022Article
- Brain Correlates of Persistent Postural-Perceptual Dizziness: A Review of Neuroimaging Studies.Journal of clinical medicine · 2021Review
- Cerebral Responses to Stationary Emotional Stimuli Measured by fMRI in Women with Persistent Postural-Perceptual Dizziness.International archives of otorhinolaryngology · 2021Article
- Clinical predictors of cybersickness in virtual reality (VR) among highly stressed people.Scientific reports · 2021Article
- Watching the Effects of Gravity. Vestibular Cortex and the Neural Representation of "Visual" Gravity.Frontiers in integrative neuroscience · 2021Review
- Behavioural and cognitive mechanisms of Developmental Topographical Disorientation.Scientific reports · 2020Article
- Structural connectome and connectivity lateralization of the multimodal vestibular cortical network.NeuroImage · 2020Article
Corrections and comments
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Authors and funding
7 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Different lines of research suggest that anxiety-related personality traits may influence the visual and vestibular control of balance, although the brain mechanisms underlying this effect remain unclear. To our knowledge, this is the first functional magnetic resonance imaging (fMRI) study that investigates how individual differences in neuroticism and introversion, two key personality traits linked to anxiety, modulate brain regional responses and functional connectivity patterns during a fMRI task simulating self-motion. Twenty-four healthy individuals with variable levels of neuroticism and introversion underwent fMRI while performing a virtual reality rollercoaster task that included two main types of trials: (1) trials simulating downward or upward self-motion (vertical motion), and (2) trials simulating self-motion in horizontal planes (horizontal motion). Regional brain activity and functional connectivity patterns when comparing vertical versus horizontal motion trials were correlated with personality traits of the Five Factor Model (i.e., neuroticism, extraversion-introversion, openness, agreeableness, and conscientiousness). When comparing vertical to horizontal motion trials, we found a positive correlation between neuroticism scores and regional activity in the left parieto-insular vestibular cortex (PIVC). For the same contrast, increased functional connectivity between the left PIVC and right amygdala was also detected as a function of higher neuroticism scores. Together, these findings provide new evidence that individual differences in personality traits linked to anxiety are significantly associated with changes in the activity and functional connectivity patterns within visuo-vestibular and anxiety-related systems during simulated vertical self-motion. Hum Brain Mapp 38:715-726, 2017. © 2016 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.