Evidence map›Paper›PMID 27677709›Full record

SynthesisCritical care (London, England)2016

Stress hyperglycaemia in critically ill patients and the subsequent risk of diabetes: a systematic review and meta-analysis.

Yasmine Ali Abdelhamid, Palash Kar, Mark E Finnis, Liza K Phillips, Mark P Plummer, Jonathan E Shaw, Michael Horowitz, Adam M Deane

Open access · goldAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Critical care (London, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 1 pooled it
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 1 synthesis or guideline pooled it, 101 citations in OpenAlex.

  1. American Association of Clinical Endocrinology Clinical Practice Guideline: Developing a Diabetes Mellitus Comprehensive Care Plan-2022 Update.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2022
    Guideline
  2. Article
  3. Observational
  4. Article
  5. Article
  6. Predictive value of admission blood glucose for early severity stratification in pediatric scorpion envenomation.The journal of venomous animals and toxins including tropical diseases · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. The Role of Stress Hyperglycemia on Delirium Onset.Journal of clinical medicine · 2025
    Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
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  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Yasmine Ali AbdelhamidIntensive Care Unit, Royal Adelaide Hospital, North Terrace, Adelaide, SA, 5000, Australia. yasmine.aliabdelhamid@adelaide.edu.au.ORCID 0000-0002-3340-1965
Palash KarIntensive Care Unit, Royal Adelaide Hospital, North Terrace, Adelaide, SA, 5000, Australia.
Mark E FinnisIntensive Care Unit, Royal Adelaide Hospital, North Terrace, Adelaide, SA, 5000, Australia.
Liza K PhillipsDiscipline of Medicine, The University of Adelaide, Adelaide, SA, 5005, Australia.
Mark P PlummerIntensive Care Unit, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 0QQ, UK.
Jonathan E ShawClinical Diabetes Laboratory, Baker IDI, 75 Commercial Road, Melbourne, VIC, 3004, Australia.
Michael HorowitzDiscipline of Medicine, The University of Adelaide, Adelaide, SA, 5005, Australia.
Adam M DeaneIntensive Care Unit, Royal Adelaide Hospital, North Terrace, Adelaide, SA, 5000, Australia.
Royal Adelaide Hospital · AUAddenbrooke's Hospital · GBBaker Heart and Diabetes Institute · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHyperglycaemia occurs frequently in critically ill patients without diabetes. We conducted a systematic review and meta-analysis to evaluate whether this 'stress hyperglycaemia' identifies survivors of critical illness at increased risk of subsequently developing diabetes.

methodsWe searched the MEDLINE and Embase databases from their inception to February 2016. We included observational studies evaluating adults admitted to the intensive care unit (ICU) who developed stress hyperglycaemia if the researchers reported incident diabetes or prediabetes diagnosed ≥3 months after hospital discharge. Two reviewers independently screened the titles and abstracts of identified studies and evaluated the full text of relevant studies. Data were extracted using pre-defined data fields, and risk of bias was assessed using the Newcastle-Ottawa Scale. Pooled ORs with 95 % CIs for the occurrence of diabetes were calculated using a random-effects model.

resultsFour cohort studies provided 2923 participants, including 698 with stress hyperglycaemia and 131 cases of newly diagnosed diabetes. Stress hyperglycaemia was associated with increased risk of incident diabetes (OR 3.48; 95 % CI 2.02-5.98; I

conclusionsStress hyperglycaemia during ICU admission is associated with increased risk of incident diabetes. The strength of this association remains uncertain because of statistical and clinical heterogeneity among the included studies.

Indexed as

Critical IllnessDiabetes MellitusHumansHyperglycemiaPrediabetic StateStress, PhysiologicalBlood glucoseCritical careHyperglycaemiaMeta-analysisPrediabetesType 2 diabetes mellitus

Identifiers

PMID27677709
PMCPMC5039881
OpenAlexW2526522708

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.