ArticleScientific reports2016
Embryonic expression of endothelins and their receptors in lamprey and frog reveals stem vertebrate origins of complex Endothelin signaling.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Dissecting the Genetic Architecture of Intracranial Aneurysms.Circulation. Genomic and precision medicine · 2025Pooled it
- Developmental dynamics of catshark cranial neural crest cells provide insights into gnathostome facial evolution.Development (Cambridge, England) · 2026Article
- Widespread Variation in EDNRB2 Is Associated With Diverse Melanin Loss Phenotypes Across Avian Species.Molecular biology and evolution · 2025Article
- Widespread variation inbioRxiv : the preprint server for biology · 2025Article
- Endothelin signaling in development.Development (Cambridge, England) · 2023Review
- Review
- Cartilage diversification and modularity drove the evolution of the ancestral vertebrate head skeleton.EvoDevo · 2023Article
- The developmental and evolutionary origins of cellular pluripotency in the vertebrate neural crest.Seminars in cell & developmental biology · 2023Review
- A Comprehensive Analysis of Fibrillar Collagens in Lamprey Suggests a Conserved Role in Vertebrate Musculoskeletal Evolution.Frontiers in cell and developmental biology · 2022Article
- Two Genomic Loci Control Three Eye Colors in the Domestic Pigeon (Columba livia).Molecular biology and evolution · 2021Article
- Riding the crest to get a head: neural crest evolution in vertebrates.Nature reviews. Neuroscience · 2021Review
- Conserved and unique transcriptional features of pharyngeal arches in the skate (Leucoraja erinacea) and evolution of the jaw.Molecular biology and evolution · 2021Article
- Ambrisentan, an endothelin receptor type A-selective antagonist, inhibits cancer cell migration, invasion, and metastasis.Scientific reports · 2020Article
- Article
- Evolutionary and Developmental Associations of Neural Crest and Placodes in the Vertebrate Head: Insights From Jawless Vertebrates.Frontiers in physiology · 2020Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neural crest cells (NCCs) are highly patterned embryonic cells that migrate along stereotyped routes to give rise to a diverse array of adult tissues and cell types. Modern NCCs are thought to have evolved from migratory neural precursors with limited developmental potential and patterning. How this occurred is poorly understood. Endothelin signaling regulates several aspects of NCC development, including their migration, differentiation, and patterning. In jawed vertebrates, Endothelin signaling involves multiple functionally distinct ligands (Edns) and receptors (Ednrs) expressed in various NCC subpopulations. To test the potential role of endothelin signaling diversification in the evolution of modern, highly patterned NCC, we analyzed the expression of the complete set of endothelin ligands and receptors in the jawless vertebrate, the sea lamprey (Petromyzon marinus). To better understand ancestral features of gnathostome edn and ednr expression, we also analyzed all known Endothelin signaling components in the African clawed frog (Xenopus laevis). We found that the sea lamprey has a gnathsotome-like complement of edn and ednr duplicates, and these genes are expressed in patterns highly reminiscent of their gnathostome counterparts. Our results suggest that the duplication and specialization of vertebrate Endothelin signaling coincided with the appearance of highly patterned and multipotent NCCs in stem vertebrates.
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Registered trials
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