ArticleInternational journal of obesity (2005)2016
Differences in brain functional connectivity at resting state in neonates born to healthy obese or normal-weight mothers.
Article in International journal of obesity (2005), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 49 citations in OpenAlex.
- Maternal obesity and the embryonic rewiring of feeding circuits: Beyond the hypothalamus.Molecular metabolism · 2026Review
- Investigating the influence of maternal prenatal BMI and perinatal depressive symptoms on neonatal brain network dynamics.Pediatric research · 2026Article
- Effortful Control and Cortical Brain Structure in 5-Year-Old Children: Findings From the FinnBrain Birth Cohort Study.The European journal of neuroscience · 2026Article
- Infant subcortical brain volumes associated with maternal obesity and diabetes: a large multicohort human study.BMC medicine · 2026Article
- Associations of Maternal Pre-Pregnancy BMI With Frontostriatal Connectivity in Young Children.Pediatric obesity · 2026Article
- Peri- and Postnatal High Fat Feeding Have Differential Effects on Executive Function and Associated Neurobiology in Aged Male and Female Mice.Aging cell · 2025Article
- Neurodevelopmental Pathways from Maternal Obesity to Offspring Outcomes: An Umbrella Review of Cognitive and Behavioral Consequences Across Development.Healthcare (Basel, Switzerland) · 2025Review
- Current states in understanding oligodendroglia-mediated neurological issues in neurofibromatosis type 1 (NF1).Acta neuropathologica communications · 2025Review
- Impact of high maternal body mass index on fetal cerebral cortical and cerebellar volumes.Journal of perinatal medicine · 2025Article
- Maternal Obesity and Neurodevelopment of the Offspring.Nutrients · 2025Review
- Possible relationship between pre-pregnancy maternal body mass index and offspring hippocampus: An experimental study in albino Wistar rat.Open veterinary journal · 2024Article
- An update on the secretory functions of brown, white, and beige adipose tissue: Towards therapeutic applications.Reviews in endocrine & metabolic disorders · 2024Review
- Associations between maternal pre-pregnancy BMI and infant striatal mean diffusivity.BMC medicine · 2024Article
- Structural brain correlates of non-verbal cognitive ability in 5-year-old children: Findings from the FinnBrain birth cohort study.Human brain mapping · 2023Article
- Maternal pre-pregnancy obesity affects the uncinate fasciculus white matter tract in preterm infants.Frontiers in pediatrics · 2023Article
- Maternal psychological distress associates with alterations in resting-state low-frequency fluctuations and distal functional connectivity of the neonate medial prefrontal cortex.The European journal of neuroscience · 2023Article
- Fetal programming of human energy homeostasis brain networks: Issues and considerations.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2022Review
- How the placenta-brain lipid axis impacts the nutritional origin of child neurodevelopmental disorders: Focus on attention deficit hyperactivity disorder and autism spectrum disorder.Experimental neurology · 2022Review
- Maternal Obesity during Pregnancy is Associated with Lower Cortical Thickness in the Neonate Brain.AJNR. American journal of neuroradiology · 2021Article
- Maternal pre-pregnancy BMI associates with neonate local and distal functional connectivity of the left superior frontal gyrus.Scientific reports · 2021Observational
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent studies have shown associations between maternal obesity at pre- or early pregnancy and long-term neurodevelopment in children, suggesting in utero effects of maternal obesity on offspring brain development. In this study, we examined whether brain functional connectivity to the prefrontal lobe network is different in newborns from normal-weight or obese mothers. Thirty-four full-term healthy infants from uncomplicated pregnancies were included, with 18 born to normal-weight and 16 born to obese mothers. Two weeks after delivery, the infants underwent an magnetic resonance imaging (MRI) examination during natural sleep, which included structural imaging and resting-state functional MRI (fMRI) scans. Independent component analysis was used to identify the prefrontal lobe network, and dual regression was used to compare functional connectivity between groups. Infants born to normal-weight mothers had higher recruiting (P<0.05, corrected) of dorsal anterior cingulate cortex regions to the prefrontal network after adjusting for maternal intelligence quotient, gestational weight gain and infant postmenstrual age, gender, birth weight/length, head circumference and neonatal diet. The functional connectivity strength in dorsal anterior cingulate cortex negatively correlated (P<0.05) with maternal fat mass percentage measured at early pregnancy. This preliminary study indicates that exposure to maternal obesity in utero may be associated with changes in resting-state functional connectivity in the newborn offspring's brain.
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