ArticleScientific reports2016
Retinoic acid and meiosis induction in adult versus embryonic gonads of medaka.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 41 citations in OpenAlex.
- Sex-specific gonadal transcriptome during early development of Siberian sturgeon.Biology of sex differences · 2026Article
- An integrated roadmap of European sea bass (Frontiers in cell and developmental biology · 2026Article
- Male Germ Cell Specification in Plants.International journal of molecular sciences · 2024Review
- Evidence for RA-dependent meiosis onset in a turtle embryo.Cell and tissue research · 2023Article
- Identification of sex chromosome and sex-determining gene of southern catfish (Proceedings. Biological sciences · 2022Article
- Functional Modules in Gametogenesis.Frontiers in cell and developmental biology · 2022Article
- Transcriptomes of testis and pituitary from male Nile tilapia (O. niloticus L.) in the context of social status.PloS one · 2022Article
- Revelation of candidate genes and molecular mechanism of reproductive seasonality in female rohu (Labeo rohita Ham.) by RNA sequencing.BMC genomics · 2021Article
- The replaceable master of sex determination: bottom-up hypothesis revisited.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
- Loss ofFrontiers in cell and developmental biology · 2021Article
- Article
- Crosstalk Between Retinoic Acid and Sex-Related Genes Controls Germ Cell Fate and Gametogenesis in Medaka.Frontiers in cell and developmental biology · 2020Article
- A Hormone That Lost Its Receptor: Anti-Müllerian Hormone (AMH) in Zebrafish Gonad Development and Sex Determination.Genetics · 2019Article
- Involvement of the retinoic acid signaling pathway in sex differentiation and pubertal development in the European sea bassHeliyon · 2019Article
- A Comparative View on Sex Differentiation and Gametogenesis Genes in Lungfish and Coelacanths.Genome biology and evolution · 2018Article
- Identification of conserved genes triggering puberty in European sea bass males (Dicentrarchus labrax) by microarray expression profiling.BMC genomics · 2017Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
In vertebrates, one of the first recognizable sex differences in embryos is the onset of meiosis, known to be regulated by retinoic acid (RA) in mammals. We investigated in medaka a possible meiotic function of RA during the embryonic sex determination (SD) period and in mature gonads. We found RA mediated transcriptional activation in germ cells of both sexes much earlier than the SD stage, however, no such activity during the critical stages of SD. In adults, expression of the RA metabolizing enzymes indicates sexually dimorphic RA levels. In testis, RA acts directly in Sertoli, Leydig and pre-meiotic germ cells. In ovaries, RA transcriptional activity is highest in meiotic oocytes. Our results show that RA plays an important role in meiosis induction and gametogenesis in adult medaka but contrary to common expectations, not for initiating the first meiosis in female germ cells at the SD stage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.