Evidence map›Paper›PMID 27677570›Full record

ArticlePediatrics2016

Mental Health and Antiretroviral Adherence Among Youth Living With HIV in Rwanda.

Mary C Smith Fawzi, Lauren Ng, Fredrick Kanyanganzi, Catherine Kirk, Justin Bizimana, Felix Cyamatare, Christina Mushashi, Taehoon Kim, Yvonne Kayiteshonga, Agnes Binagwaho and 1 more

Abstract read
In one paragraph

Article in Pediatrics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 5 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 5 syntheses or guidelines pooled it, 77 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Mary C Smith FawziDepartment of Global Health and Social Medicine, Harvard Medical School, Boston, Massachusetts; mary_smith-fawzi@hms.harvard.edu.
Lauren NgDivision of Global Psychiatry, Massachusetts General Hospital, Boston, Massachusetts.
Fredrick KanyanganziPartners In Health-Rwanda/ Inshuti Mu Buzima (PIH/IMB), Rwinkwavu, Rwanda.
Catherine KirkDepartment of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
Justin BizimanaMinistry of Health, Government of Rwanda, Kigali, Rwanda.
Felix CyamatarePartners In Health-Rwanda/ Inshuti Mu Buzima (PIH/IMB), Rwinkwavu, Rwanda.
Christina MushashiPartners In Health-Rwanda/ Inshuti Mu Buzima (PIH/IMB), Rwinkwavu, Rwanda.
Taehoon KimDepartment of Global Health and Social Medicine, Harvard Medical School, Boston, Massachusetts.
Yvonne KayiteshongaMinistry of Health, Government of Rwanda, Kigali, Rwanda.
Agnes BinagwahoDepartment of Global Health and Social Medicine, Harvard Medical School, Boston, Massachusetts.
Theresa S BetancourtDepartment of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
Harvard Global Health Institute · USHarvard University · USMinistry of Infrastructure · RWDartmouth College · USMassachusetts General Hospital · US

Funding

The impact of HIV viral diversity and cellular immunity on HIV pathogenesisP30AI060354 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI ROBERT A. PARKER · 2004 to 2026
$94.4M
The MGH Global Psychiatric Clinical Research Training ProgramT32MH093310 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI FRICCHIONE, GREGORY L, HENDERSON, DAVID C · 2012 to 2016
$1.3M
Family-Based Prevention of Mental Health Problems in HIV/AIDS Affected ChildrenR34MH084679 · NIMH · HARVARD SCHOOL OF PUBLIC HEALTH · PI BETANCOURT, THERESA STICHICK · 2011 to 2013
$932k
NIAID NIH HHS P30 AI060354NIMH NIH HHS R34 MH084679NIMH NIH HHS T32 MH093310
6 · The paper itself

Abstract

BACKGROUND AND

objectivesIn Rwanda, significant progress has been made in advancing access to antiretroviral therapy (ART) among youth. As availability of ART increases, adherence is critical for preventing poor clinical outcomes and transmission of HIV. The goals of the study are to (1) describe ART adherence and mental health problems among youth living with HIV aged 10 to 17; and (2) examine the association between these factors among this population in rural Rwanda.

methodsA cross-sectional analysis was conducted that examined the association of mental health status and ART adherence among youth (n = 193). ART adherence, mental health status, and related variables were examined based on caregiver and youth report. Nonadherence was defined as ever missing or refusing a dose of ART within the past month. Multivariate modeling was performed to examine the association between mental health status and ART adherence.

resultsApproximately 37% of youth missed or refused ART in the past month. In addition, a high level of depressive symptoms (26%) and attempt to hurt or kill oneself (12%) was observed in this population of youth living with HIV in Rwanda. In multivariate analysis, nonadherence was significantly associated with some mental health outcomes, including conduct problems (odds ratio 2.90, 95% confidence interval 1.55-5.43) and depression (odds ratio 1.02, 95% confidence interval 1.01-1.04), according to caregiver report. A marginally significant association was observed for youth report of depressive symptoms.

conclusionsThe findings suggest that mental health should be considered among the factors related to ART nonadherence in HIV services for youth, particularly for mental health outcomes, such as conduct problems and depression.

Indexed as

AdolescentAnti-HIV AgentsChildCross-Sectional StudiesFemaleHIV InfectionsHumansMaleMedication AdherenceMental DisordersMental HealthRural PopulationRwandaAnti-HIV Agents

Identifiers

PMID27677570
PMCPMC5051202
OpenAlexW2527423419

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.