Evidence map›Paper›PMID 27677525›Full record

ArticleChemMedChem2016

15-Methylene-Eburnamonine Kills Leukemic Stem Cells and Reduces Engraftment in a Humanized Bone Marrow Xenograft Mouse Model of Leukemia.

Dilini C Gunasekara, Mary M Zheng, Tara Mojtahed, James R Woods, Tamer E Fandy, Mark V Riofski, Carlotta A Glackin, Hazem E Hassan, Julia Kirshner, David A Colby

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ChemMedChem, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 3 countries.

Dilini C GunasekaraDepartment of Biological Sciences, Purdue University, West Lafayette, IN, USA.
Mary M ZhengDepartment of Biological Sciences, Purdue University, West Lafayette, IN, USA.
Tara MojtahedDepartment of Biological Sciences, Purdue University, West Lafayette, IN, USA.
James R WoodsDepartment of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN, USA.
Tamer E FandyDepartment of Pharmaceutical Sciences, Albany College of Pharmacy, Colchester, VT, USA.
Mark V RiofskiDepartment of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN, USA.
Carlotta A GlackinDivision of Neurosciences, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA, USA.
Hazem E HassanDepartment of Pharmaceutical Sciences, University of Maryland, Baltimore, MD, USA.
Julia KirshnerzPredicta, Palo Alto, CA, USA.
David A ColbyDepartment of BioMolecular Sciences, University of Mississippi, University, MS, USA.ORCID http://orcid.org/0000-0002-5434-1690
Purdue University West Lafayette · USAlbany College of Pharmacy and Health Sciences · USBiopredic (France) · FRCity Of Hope National Medical Center · USUniversity of Maryland, Baltimore · USUniversity of Mississippi · US

Funding

Indiana Clinical and Translational Sciences InstituteUL1TR001108 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI DENNE, SCOTT C., SHEKHAR, ANANTHA · 2013 to 2017
$23.3M
INDIANA CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTE (UL1): BPCAUL1RR025761 · NCRR · INDIANA UNIVERSITY INDIANAPOLIS · PI SHEKHAR, ANANTHA · 2008 to 2011
$21.0M
Characterization of the Multiple Myeloma Cancer Stem Cell and its NicheR21CA141039 · NCI · PURDUE UNIVERSITY · PI AGUILAR, RUBEN CLAUDIO · 2011 to 2012
$348k
NCATS NIH HHS UL1 TR001108NCI NIH HHS R21 CA141039NCRR NIH HHS UL1 RR025761NIH/NCRR RR025761US National Cancer Institute 1R21A141039
6 · The paper itself

Abstract

Recent studies suggest that leukemia stem cells (LSCs) play a critical role in the initiation, propagation, and relapse of leukemia. Herein we show that (-)-15-methylene-eburnamonine, a derivative of the alkaloid (-)-eburnamonine, is cytotoxic against acute and chronic lymphocytic leukemias (ALL and CLL) and acute myelogenous leukemia (AML). The agent also decreases primary LSC frequency in vitro. The cytotoxic effects appear to be mediated via the oxidative stress pathways. Furthermore, we show that the compound kills AML, ALL, and CLL stem cells. By the use of a novel humanized bone marrow murine model of leukemia (huBM/NSG), it was found to decrease progenitor cell engraftment.

Indexed as

cancer stem cellsglutathioneleukemianatural productsxenograft models

Identifiers

PMID27677525
PMCPMC5373928
OpenAlexW2524469409

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.