ArticleScientific reports2016
FAK deletion accelerates liver regeneration after two-thirds partial hepatectomy.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Meta-analysis of liver venous deprivation vs portal vein embolization in treating liver cancer with an insufficient liver remnant.Journal of the Chinese Medical Association : JCMA · 2025Pooled it
- Monocarboxylate Transporter-1 Is Dispensable for Hepatocellular Carcinoma Development.Molecular carcinogenesis · 2025Article
- Sublethal executioner caspase activation in hepatocytes promotes liver regeneration through the JAK/STAT3 pathway.PLoS biology · 2025Article
- Single-cell morphological tracking of cell states to identify small-molecule modulators of liver differentiation.iScience · 2025Article
- Suppression of Hepatocellular Carcinoma by Deletion of SIRT2 in Hepatocytes via Elevated C/EBPβ/GADD45γ.Cellular and molecular gastroenterology and hepatology · 2025Article
- Insights Into Transcriptome Profiles Associated With Wooden Breast Myopathy in Broilers Slaughtered at the Age of 6 or 7 Weeks.Frontiers in physiology · 2021Article
- Focal Adhesion Kinase and β-Catenin Cooperate to Induce Hepatocellular Carcinoma.Hepatology (Baltimore, Md.) · 2019Article
- Epigenetic Compensation Promotes Liver Regeneration.Developmental cell · 2019Article
- The Role of Adipokines in Surgical Procedures Requiring Both Liver Regeneration and Vascular Occlusion.International journal of molecular sciences · 2018Review
- Effect of substrate stiffness on hepatocyte migration and cellular Young's modulus.Journal of cellular physiology · 2018Article
- Inhibition of insulin-like growth factor 1 receptor enhances the efficacy of sorafenib in inhibiting hepatocellular carcinoma cell growth and survival.Hepatology communications · 2018Article
- Estrogen Accelerates Cell Proliferation through Estrogen Receptor α during Rat Liver Regeneration after Partial Hepatectomy.Acta histochemica et cytochemica · 2017Article
- The inhibition of lung cancer cell migration by AhR-regulated autophagy.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Understanding the molecular mechanisms of liver regeneration is essential to improve the survival rate of patients after surgical resection of large amounts of liver tissue. Focal adhesion kinase (FAK) regulates different cellular functions, including cell survival, proliferation and cell migration. The role of FAK in liver regeneration remains unknown. In this study, we found that Fak is activated and induced during liver regeneration after two-thirds partial hepatectomy (PHx). We used mice with liver-specific deletion of Fak and investigated the role of Fak in liver regeneration in 2/3 PHx model (removal of 2/3 of the liver). We found that specific deletion of Fak accelerates liver regeneration. Fak deletion enhances hepatocyte proliferation prior to day 3 post-PHx but attenuates hepatocyte proliferation 3 days after PHx. Moreover, we demonstrated that the deletion of Fak in liver transiently increases EGFR activation by regulating the TNFα/HB-EGF axis during liver regeneration. Furthermore, we found more apoptosis in Fak-deficient mouse livers compared to WT mouse livers after PHx.
conclusionOur data suggest that Fak is involved in the process of liver regeneration, and inhibition of FAK may be a promising strategy to accelerate liver regeneration in recipients after liver transplantation.
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Registered trials
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