Evidence map›Paper›PMID 27677156›Full record

ArticleVirology2016

CD4

Andreas C Solomos, Kevin J O'Regan, Glenn F Rall

Abstract read
In one paragraph

Article in Virology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Andreas C SolomosFox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, United States; Drexel University College of Medicine, Department of Microbiology and Immunology, 2900 W. Queen Lane, Philadelphia, PA 19129, United States.
Kevin J O'ReganFox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, United States.
Glenn F RallFox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, United States. Electronic address: glenn.rall@fccc.edu.

Funding

WORD PROCESSING CENTER--COREP30CA006927 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI Margaret von Mehren · 1985 to 2026
$138.8M
Pathogenesis of Neurotropic RNA Virus InfectionsR01NS040500 · NINDS · RESEARCH INST OF FOX CHASE CAN CTR · PI RALL, GLENN F · 2002 to 2006
$1.6M
Regulation and Relevance of Neuron-Specific Interferon Signaling PathwaysR56NS094475 · NINDS · RESEARCH INST OF FOX CHASE CAN CTR · PI RALL, GLENN F · 2016 to 2016
$443k
NCI NIH HHS P30 CA006927NINDS NIH HHS R01 NS040500NINDS NIH HHS R56 NS094475
6 · The paper itself

Abstract

Immunity within the brain, specifically to virus-infected neurons, must be controlled to prevent neuron loss and impairment, though the process by which this occurs remains unclear. Here, we use a mouse model of neuron-restricted measles virus infection, in which immunocompetent adults survive challenge, whereas T and B cell-deficient mice succumb. This model allowed us to more precisely define the contributions of CD4

Indexed as

AnimalsB-LymphocytesBrainCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesFemaleHumansMaleMeaslesMeasles virusMiceMice, Inbred C57BLViral TropismVirulenceAdaptive immunityMeaslesNeuronTransgenic mice

Identifiers

PMID27677156
PMCPMC5102754

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.