ArticleThe Journal of clinical endocrinology and metabolism2016
Autoimmune Diseases in Children and Adults With Type 1 Diabetes From the T1D Exchange Clinic Registry.
Article in The Journal of clinical endocrinology and metabolism, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it, 162 citations in OpenAlex.
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- Islet Autoantibodies in Adult With Pituitary and Ovarian Autoimmunity: Implications for Type 1 Diabetes Screening.Diabetes, obesity & metabolism · 2026Article
- Glucometabolic Control and Anti-Transglutaminase Antibodies at Celiac Disease Onset in Type 1 Diabetes Youth.The Journal of clinical endocrinology and metabolism · 2026Observational
- Association of Individual or Family History of Autoimmune Disease With Future Development of Type 1 Diabetes.Diabetes/metabolism research and reviews · 2026Review
- 14. Children and Adolescents: Standards of Care in Diabetes-2026.Diabetes care · 2026Review
- 4. Comprehensive Medical Evaluation and Assessment of Comorbidities: Standards of Care in Diabetes-2026.Diabetes care · 2026Review
- Underlying mechanisms of exercise protection against diabetes mellitus: a narrative review.Frontiers in endocrinology · 2026Review
- Prevalence of autoimmune comorbidities and association with glycemic control by CGM-derived parameters in type 1 diabetes.Endocrine · 2025Article
- Genetic evidence for causal links between type 1 diabetes and autoimmune liver diseases.Diabetology & metabolic syndrome · 2025Article
- Risk of new-onset type 1 diabetes in individuals with celiac disease and thyroid disease-An observational study.Diabetes, obesity & metabolism · 2025Observational
- Pseudoascites Due to Celiac Disease in a Patient with Type 1 Diabetes.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2025Article
- DNA methylation and 28 year incidence of two neuropathy phenotypes in type 1 diabetes: the Pittsburgh Epidemiology of Diabetes Complications cohort study.Diabetologia · 2025Article
- Comparison of immunological and immunogenetic markers in recent-onset type 1 diabetes among children and adults.Scientific reports · 2025Article
- 4. Comprehensive Medical Evaluation and Assessment of Comorbidities: Standards of Care in Diabetes-2025.Diabetes care · 2025Review
- 14. Children and Adolescents: Standards of Care in Diabetes-2025.Diabetes care · 2025Review
- Association of the Immunity Genes with Type 1 Diabetes Mellitus.Current diabetes reviews · 2025Review
- Autoimmune comorbidity in type 1 diabetes and its association with metabolic control and mortality risk in young people: a population-based study.Diabetologia · 2024Article
- Prevalence of autoimmune diseases in an admixed population of patients with type 1 diabetes: a multicenter study in Brazil.Diabetology & metabolic syndrome · 2024Article
- 14. Children and Adolescents: Standards of Care in Diabetes-2024.Diabetes care · 2024Review
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
BACKGROUND AND
aimsType 1 diabetes (T1D) is associated with other autoimmune diseases (AIDs), but the prevalence and associated predictive factors for these comorbidities of T1D across all age groups have not been fully characterized. MATERIALS AND
methodsData obtained from 25 759 participants with T1D enrolled in the T1D Exchange Registry were used to analyze the types and frequency of AIDs as well as their relationships to gender, age, and race/ethnicity. Diagnoses of autoimmune diseases, represented as ordinal categories (0, 1, 2, 3, or more AIDs) were obtained from medical records of Exchange Registry participants.
resultsAmong the 25 759 T1D Exchange participants, 50% were female, 82% non-Hispanic white, mean age was 23.0 ± 16.9 years and mean duration of diabetes was 11 years. Of these participants, 6876 (27%) were diagnosed with at least one AID. Frequency of two or more AIDs increased from 4.3% in participants aged younger than 13 years to 10.4% in those aged 50 years or older. The most common AIDs were thyroid (6097, 24%), gastrointestinal (1530, 6%), and collagen vascular diseases (432, 2%). Addison's disease was rare (75, 0.3%). The prevalence of one or more AIDs was increased in females and non-Hispanic whites and with older age.
conclusionsIn the T1D Exchange Clinic Registry, a diagnosis of one or more AIDs in addition to T1D is common, particularly in women, non-Hispanic whites, and older individuals. Results of this study have implications for both primary care and endocrine practice and will allow clinicians to better anticipate and manage the additional AIDs that develop in patients with T1D.
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