ArticleHeadache2017
Headache Disorders May Be a Risk Factor for the Development of New Onset Hypothyroidism.
Article in Headache, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02295085 (Fernald Community Cohort - 18 Year Observational Study with Bio Banked Blood and Urine Samples), which is not on this map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Fernald Community Cohort - 18 Year Observational Study with Bio Banked Blood and Urine Samples
Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Effectiveness of low dose thyroxine in patients with subclinical hypothyroidism and migraine; systematic review and meta-analysis.BMC neurology · 2025Pooled it
- Pooled it
- What Is the Link Between Migraine and Hypothyroidism? A Systematic Literature Review.Journal of clinical medicine · 2025Review
- Relationship between cognitive disengagement syndrome and headache in children: insights from biochemical markers.Frontiers in psychiatry · 2025Article
- Influence of metabolic state and body composition on the action of pharmacological treatment of migraine.The journal of headache and pain · 2024Review
- The relationship between migraine and Hashimoto's thyroiditis: a single center experience.Frontiers in neurology · 2024Article
- Potential Association between Subclinical Hypothyroidism and Childhood Migraine.Medicina (Kaunas, Lithuania) · 2022Article
- Comorbidity between hypothyroidism and headache disorders in a Mexican population.Revista de neurologia · 2022Article
- High rates of (treated) hypothyroidism among chronic migraine patients consulting a specialized headache clinic: are we missing something?Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Article
- Headache and immunological/autoimmune disorders: a comprehensive review of available epidemiological evidence with insights on potential underlying mechanisms.Journal of neuroinflammation · 2021Review
- Pathophysiological Bases of Comorbidity in Migraine.Frontiers in human neuroscience · 2021Review
- Episodic Migraine Comorbidities: Avoiding Pitfalls and Taking Therapeutic Opportunities.Current pain and headache reports · 2019Review
- Common variants at 5q33.1 predispose to migraine in African-American children.Journal of medical genetics · 2018Article
- Is Migraine Primarily a Metaboloendocrine Disorder?Current pain and headache reports · 2018Review
- Migrainomics - identifying brain and genetic markers of migraine.Nature reviews. Neurology · 2017Review
- Headache: Headache disorders may be a harbinger of hypothyroidism.Nature reviews. Neurology · 2016Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo determine whether headache disorders are a risk factor for the development of new onset hypothyroidism.
backgroundPast studies have reported associations between headache disorders and hypothyroidism, but the directionality of the association is unknown.
methodsThis was a longitudinal retrospective cohort study using data from the Fernald Medical Monitoring Program (FMMP). Residents received physical examinations and thyroid function testing every 3 years during the 20 year program. Residents were excluded from the cohort if there was evidence of past thyroid disease or abnormal thyroid function tests at the first office visit. A diagnosis of a headache disorder was established by self-report of "frequent headaches," use of any headache-specific medication, or a physician diagnosis of a headache disorder. The primary outcome measure was new onset hypothyroidism defined as the initiation of thyroid replacement therapy or TSH ≥ 10 without thyroid medication. A Cox survival analysis with time dependent variables were used for the model. Headache disorders, age, sex, body mass index, income, smoking, narcotic use, and hypothyroidism-producing medications were independent variables in the model.
resultsData from 8412 residents enrolled in the FMMP were used in the current study. Headache disorders were present in about 26% of the residents and new onset hypothyroidism developed in ∼7%. The hazard ratio for the development of new onset hypothyroidism was 1.21 (95% CI = 1.001, 1.462) for those with headache disorders.
conclusionsHeadache disorders may be associated with an increased risk for the development of new onset hypothyroidism.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.