ArticlePLoS pathogens2016
A Small Cysteine-Rich Protein from the Asian Soybean Rust Fungus, Phakopsora pachyrhizi, Suppresses Plant Immunity.
Article in PLoS pathogens, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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Who cites it
38 citing papers in PubMed, 77 citations in OpenAlex.
- Integrated Functional Characterization of Hemileia vastatrix Effector Candidates Reveals Coordinated Immune Suppression, Sequential Deployment and Compartment-Specific Targeting.Molecular plant pathology · 2026Article
- Mechanism of Virulence in Fungal Pathogens with Diverse Modes of Living.Current microbiology · 2026Review
- Targeting the EffectorFoods (Basel, Switzerland) · 2026Article
- An Apple Susceptibility-Related LRR Receptor-Like Kinase MdRLKT21 Activates Plant Immunity by Hijacking a Trans-Kingdom Fungal microRNA-Like RNA.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- A Necrotrophic Phytopathogen-Derived GPI-Anchored Protein Functions as an Elicitor to Activate Plant Immunity and Enhance Resistance.Molecular plant pathology · 2025Article
- Soybean-Phakopsora pachyrhizi interactions: towards the development of next-generation disease-resistant plants.Plant biotechnology journal · 2024Review
- Variability and functional characterization of the Phakopsora pachyrhizi Egh16-like effectors.Genetics and molecular biology · 2024Article
- Nuclear effectors of plant pathogens: Distinct strategies to be one step ahead.Molecular plant pathology · 2023Review
- TheInternational journal of molecular sciences · 2023Article
- A novel protein elicitor (PeSy1) from Saccharothrix yanglingensis induces plant resistance and interacts with a receptor-like cytoplasmic kinase in Nicotiana benthamiana.Molecular plant pathology · 2023Article
- Pollen Coat Proteomes ofBiomolecules · 2023Article
- The N-terminus of a Fusarium graminearum-secreted protein enhances broad-spectrum disease resistance in plants.Molecular plant pathology · 2022Article
- Effector-Dependent and -Independent Molecular Mechanisms of Soybean-Microbe Interaction.International journal of molecular sciences · 2022Review
- Current Status and Future Perspectives of Genomics Research in the Rust Fungi.International journal of molecular sciences · 2022Review
- Action Mechanisms of Effectors in Plant-Pathogen Interaction.International journal of molecular sciences · 2022Review
- Pathogen effectors: What do they do at plasmodesmata?Molecular plant pathology · 2022Review
- A rust fungus effector directly binds plant pre-mRNA splice site to reprogram alternative splicing and suppress host immunity.Plant biotechnology journal · 2022Article
- Verticillium dahliae CFEM proteins manipulate host immunity and differentially contribute to virulence.BMC biology · 2022Article
- Article
- Infection Strategies and Pathogenicity of Biotrophic Plant Fungal Pathogens.Frontiers in microbiology · 2022Review
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Asian soybean rust fungus, Phakopsora pachyrhizi, is an obligate biotrophic pathogen causing severe soybean disease epidemics. Molecular mechanisms by which P. pachyrhizi and other rust fungi interact with their host plants are poorly understood. The genomes of all rust fungi encode many small, secreted cysteine-rich proteins (SSCRP). While these proteins are thought to function within the host, their roles are completely unknown. Here, we present the characterization of P. pachyrhizi effector candidate 23 (PpEC23), a SSCRP that we show to suppress plant immunity. Furthermore, we show that PpEC23 interacts with soybean transcription factor GmSPL12l and that soybean plants in which GmSPL12l is silenced have constitutively active immunity, thereby identifying GmSPL12l as a negative regulator of soybean defenses. Collectively, our data present evidence for a virulence function of a rust SSCRP and suggest that PpEC23 is able to suppress soybean immune responses and physically interact with soybean transcription factor GmSPL12l, a negative immune regulator.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.