Evidence map›Paper›PMID 27676089›Full record

ArticleJournal of medicinal chemistry2016

A Cyclic Tetrapeptide ("Cyclodal") and Its Mirror-Image Isomer Are Both High-Affinity μ Opioid Receptor Antagonists.

Grazyna Weltrowska, Thi M-D Nguyen, Nga N Chung, JodiAnne Wood, Xiaoyu Ma, Jason Guo, Brian C Wilkes, Yang Ge, André Laferrière, Terence J Coderre and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medicinal chemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Antinociceptive potency of a fluorinated cyclopeptide Dmt-c[D-Lys-Phe-p-CFJournal of enzyme inhibition and medicinal chemistry · 2018
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Grazyna WeltrowskaLaboratory of Chemical Biology and Peptide Research, Clinical Research Institute of Montreal , 110 Pine Avenue des Pins Ouest, Montreal, Quebec H2W 1R7, Canada.
Thi M-D NguyenLaboratory of Chemical Biology and Peptide Research, Clinical Research Institute of Montreal , 110 Pine Avenue des Pins Ouest, Montreal, Quebec H2W 1R7, Canada.
Nga N ChungLaboratory of Chemical Biology and Peptide Research, Clinical Research Institute of Montreal , 110 Pine Avenue des Pins Ouest, Montreal, Quebec H2W 1R7, Canada.
JodiAnne WoodCenter for Drug Discovery, Northeastern University , 360 Huntington Avenue, Boston, Massachusetts 02115, United States.
Xiaoyu MaCenter for Drug Discovery, Northeastern University , 360 Huntington Avenue, Boston, Massachusetts 02115, United States.
Jason GuoCenter for Drug Discovery, Northeastern University , 360 Huntington Avenue, Boston, Massachusetts 02115, United States.
Brian C WilkesLaboratory of Chemical Biology and Peptide Research, Clinical Research Institute of Montreal , 110 Pine Avenue des Pins Ouest, Montreal, Quebec H2W 1R7, Canada.
Yang GeAnesthesia Research Unit, Department of Anesthesia, McGill University , 3655 Promenade Sir William Osler, Montreal, Quebec H3G 1Y6, Canada.
André LaferrièreAnesthesia Research Unit, Department of Anesthesia, McGill University , 3655 Promenade Sir William Osler, Montreal, Quebec H3G 1Y6, Canada.
Terence J CoderreAnesthesia Research Unit, Department of Anesthesia, McGill University , 3655 Promenade Sir William Osler, Montreal, Quebec H3G 1Y6, Canada.
Peter W SchillerLaboratory of Chemical Biology and Peptide Research, Clinical Research Institute of Montreal , 110 Pine Avenue des Pins Ouest, Montreal, Quebec H2W 1R7, Canada.
Montreal Clinical Research Institute · CANortheastern University · USMcGill University · CAWilliam Osler Health System · CA

Funding

DEVELOPMENT OF RECEPTOR-SPECIFIC OPIOID PEPTIDE ANALOGSR01DA004443 · NIDA · CLINICAL RESEARCH INSTITUTE OF MONTREAL · PI SCHILLER, PETER W · 1987 to 2016
$2.0M
Anandamide Carrier Proteins as Drug TargetsR33DA032020 · NIDA · NORTHEASTERN UNIVERSITY · PI GUO, JASON JIANXIN · 2014 to 2015
$767k
DEVELOPMENT OF RECEPTOR SPECIFIC OPIOID PEPTIDE ANALOGSR37DA004443 · NIDA · CLINICAL RESEARCH INSTITUTE OF MONTREAL · PI SCHILLER, PETER W · 1997 to 2003
$621k
Anandamide Carrier Proteins as Drug TargetsR21DA032020 · NIDA · NORTHEASTERN UNIVERSITY · PI GUO, JASON JIANXIN · 2012 to 2013
$274k
Canadian Institutes of Health Research MOP-119279Canadian Institutes of Health Research MOP-89716NIDA NIH HHS R01 DA004443NIDA NIH HHS R21 DA032020NIDA NIH HHS R33 DA032020NIDA NIH HHS R37 DA004443
6 · The paper itself

Abstract

Head-to-tail cyclization of the μ opioid receptor (MOR) agonist [Dmt

Indexed as

Amino Acid SequenceAnimalsBrainGuinea PigsIsomerismMaleMiceMolecular Docking SimulationPeptides, CyclicRats, Sprague-DawleyReceptors, Opioid, muPeptides, CyclicReceptors, Opioid, mu

Identifiers

PMID27676089
PMCPMC5222732
OpenAlexW2527322529

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.