ArticleTissue engineering. Part A2016
In Vivo Cellular Infiltration and Remodeling in a Decellularized Ovine Osteochondral Allograft.
Article in Tissue engineering. Part A, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systematic Comparison of Biomaterials-Based Strategies for Osteochondral and Chondral Repair in Large Animal Models.Advanced healthcare materials · 2021Pooled it
- Integrative cartilage repair using acellular allografts for engineered structure and surface lubrication in vivo.NPJ Regenerative medicine · 2024Article
- Epigenetic Priming Enhances Chondrogenic Potential of Expanded Chondrocytes.Tissue engineering. Part A · 2024Article
- Cell Therapy Approaches for Articular Cartilage Regeneration.Organogenesis · 2023Review
- Mechanical memory stored through epigenetic remodeling reduces cell therapeutic potential.Biophysical journal · 2023Article
- Recellularization and Integration of Dense Extracellular Matrix by Percolation of Tissue Microparticles.Advanced functional materials · 2021Article
- Osteochondral Tissue Engineering: The Potential of Electrospinning and Additive Manufacturing.Pharmaceutics · 2021Review
- Applications of Biocompatible Scaffold Materials in Stem Cell-Based Cartilage Tissue Engineering.Frontiers in bioengineering and biotechnology · 2021Review
- Small Ruminant Models for Articular Cartilage Regeneration by Scaffold-Based Tissue Engineering.Stem cells international · 2021Review
- 3D printing of tissue engineering scaffolds: a focus on vascular regeneration.Bio-design and manufacturing · 2021Review
- Article
- Regulation of decellularized tissue remodeling via scaffold-mediated lentiviral delivery in anatomically-shaped osteochondral constructs.Biomaterials · 2018Article
- Functionality of decellularized matrix in cartilage regeneration: A comparison of tissue versus cell sources.Acta biomaterialia · 2018Review
- "Patient reported outcomes" following experimental surgery-using telemetry to assess movement in experimental ovine models.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2018Article
- [Preparation of acellular matrix from antler cartilage and its biological compatibility].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2017Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Interest in decellularized tissues has steadily gained as potential solutions for degenerative diseases and traumatic events, replacing sites of missing tissue, and providing the relevant biochemistry and microstructure for tissue ingrowth and regeneration. Osteoarthritis, a progressive and debilitating disease, is often initiated with the formation of a focal defect in the otherwise smooth surface of articular cartilage. Decellularized cartilage tissue, which maintains the structural complexity of the native extracellular matrix, has the potential to provide a clinically relevant solution to focal defects or large tissue damage, possibly even circumventing or complementing current techniques such as microfracture and mosaicplasty. However, it is currently unclear whether implantation of decellularized cartilage in vivo may provide a mechanically and biochemically relevant platform to promote cell remodeling and repair. We examined whole decellularized osteochondral allografts implanted in the ovine trochlear groove to investigate cellular remodeling and repair tissue quality compared to empty defects and contralateral controls (healthy cartilage). At 3 months postsurgery, cells were observed in both the decellularized tissue and empty defects, although both at significantly lower levels than healthy cartilage. Qualitative and quantitative histological analysis demonstrated maintenance of cartilage features of the decellularized implant similar to healthy cartilage groups. Noninvasive analysis by quantitative magnetic resonance imaging showed no difference in T
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.