ArticlePloS one
The Association of Hydration Status with Physical Signs, Symptoms and Survival in Advanced Cancer-The Use of Bioelectrical Impedance Vector Analysis (BIVA) Technology to Evaluate Fluid Volume in Palliative Care: An Observational Study.
Article in PloS one. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 32 citations in OpenAlex.
- Trial
- Undetectable brain natriuretic peptide as a marker of ultrasound-detected hypovolemia in patients with cancer on active treatment.Frontiers in cardiovascular medicine · 2026Article
- Predictive classification and regression models for bioimpedance vector analysis: Insights from a southern Cuban cohort.Journal of electrical bioimpedance · 2025Article
- Non-invasive technology to assess hydration status in advanced cancer to explore relationships between fluid status and symptoms: an observational study using bioelectrical impedance analysis.BMC palliative care · 2024Observational
- Bioelectrical Impedance Analysis (BIA) for the Assessment of Body Composition in Oncology: A Scoping Review.Nutrients · 2023Article
- Current Status of Korean Alcohol Drinking in Accordance with the Korean Alcohol Guidelines for Moderate Drinking Based on Facial Flushing.Korean journal of family medicine · 2023Article
- FPGA-Based Processor for Continual Capacitive-Coupling Impedance Spectroscopy and Circuit Parameter Estimation.Sensors (Basel, Switzerland) · 2022Article
- The effect of the RadioProtect cosmetic formulation on the skin of oncological patients treated with selected cytostatic drugs and ionizing radiation.Postepy dermatologii i alergologii · 2022Article
- Short-Time Impedance Spectroscopy Using a Mode-Switching Nonsinusoidal Oscillator: Applicability to Biological Tissues and Continuous Measurement.Sensors (Basel, Switzerland) · 2021Article
- Hydration and symptoms in the last days of life.BMJ supportive & palliative care · 2021Observational
- Capacitive-Coupling Impedance Spectroscopy Using a Non-Sinusoidal Oscillator and Discrete-Time Fourier Transform: An Introductory Study.Sensors (Basel, Switzerland) · 2020Article
- Early 7-day supplemental parenteral nutrition improves body composition and muscle strength in hypophagic cancer patients at nutritional risk.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2019Article
- Phase Angle and the Diagnosis of Impending Death in Patients with Advanced Cancer: Preliminary Findings.The oncologist · 2019Observational
- Bioelectrical impedance vector analysis and phase angle in boys with Duchenne muscular dystrophy.Food & nutrition research · 2019Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundHydration in advanced cancer is a controversial area; however, current hydration assessments methods are poorly developed. Bioelectrical impedance vector analysis (BIVA) is an accurate hydration tool; however its application in advanced cancer has not been explored. This study used BIVA to evaluate hydration status in advanced cancer to examine the association of fluid status with symptoms, physical signs, renal biochemical measures and survival. MATERIALS AND
methodsAn observational study of 90 adults with advanced cancer receiving care in a UK specialist palliative care inpatient unit was conducted. Hydration status was assessed using BIVA in addition to assessments of symptoms, physical signs, performance status, renal biochemical measures, oral fluid intake and medications. The association of clinical variables with hydration was evaluated using regression analysis. A survival analysis was conducted to examine the influence of hydration status and renal failure.
resultsThe hydration status of participants was normal in 43 (47.8%), 'more hydrated' in 37 (41.1%) and 'less hydrated' in 10 (11.1%). Lower hydration was associated with increased symptom intensity (Beta = -0.29, p = 0.04) and higher scores for physical signs associated with dehydration (Beta = 10.94, p = 0.02). Higher hydration was associated with oedema (Beta = 2.55, p<0.001). Median survival was statistically significantly shorter in 'less hydrated' patients (44 vs. 68 days; p = 0.049) and in pre-renal failure (44 vs. 100 days; p = 0.003).
conclusionsIn advanced cancer, hydration status was associated with clinical signs and symptoms. Hydration status and pre-renal failure were independent predictors of survival. Further studies can establish the utility of BIVA as a standardised hydration assessment tool and explore its potential research application, in order to inform the clinical management of fluid balance in patients with advanced cancer.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.