Evidence map›Paper›PMID 27673558›Full record

ReviewBiomarkers in medicine2016

Potential usefulness of apolipoprotein A2 isoforms for screening and risk stratification of pancreatic cancer.

Kazufumi Honda, Sudhir Srivastava

Open access · hybridAbstract readReview
In one paragraph

Review in Biomarkers in medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.1field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 36 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 3 countries.

Kazufumi HondaDivision of Chemotherapy & Clinical Research, National Cancer Center Research Institute, Tokyo 104-0045, Japan.
Sudhir SrivastavaDivision of Cancer Prevention, National Cancer Institute, Rockville, MD 20852, USA.
Japan Agency for Medical Research and Development · JPNational Cancer Institute · US

Funding

Intramural NIH HHS Z99 CA999999
6 · The paper itself

Abstract

Given the low incidence of pancreatic cancer in the general population, screening of pancreatic cancer in the general population using invasive modalities is not feasible. Combination of invasive screening with noninvasive biomarkers for pancreatic cancer and its precancerous lesions has the potential to reduce mortality due to pancreatic cancer. In this review, we focus on biomarkers found in the blood that can indicate early-stage pancreatic cancer, and we discuss current strategies for screening for pancreatic cancer. We recently identified a unique alteration in apolipoprotein A2 isoforms in pancreatic cancer and its precancerous lesions, and we describe its clinical usefulness as a potential biomarker for the early detection and risk stratification of pancreatic cancer.

Indexed as

Antigens, Tumor-Associated, CarbohydrateApolipoprotein A-IIArea Under CurveBiomarkers, TumorCarcinoembryonic AntigenEarly Detection of CancerHumansPancreatic NeoplasmsProtein IsoformsRisk FactorsROC CurveAntigens, Tumor-Associated, CarbohydrateApolipoprotein A-IIBiomarkers, Tumorcarbohydrate antigen 199, humanCarcinoembryonic AntigenProtein Isoformsapolipoprotein A2 isoformsearly detection for pancreatic cancerNational Cancer Institute Early Detection Research NetworkNCI EDRNplasma/serum biomarker

Identifiers

PMID27673558
PMCPMC5493967
OpenAlexW2524080253

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.