Evidence map›Paper›PMID 27673503›Full record

ArticleJournal of psychiatry & neuroscience : JPN2017

Cortical morphology as a shared neurobiological substrate of attention-deficit/hyperactivity symptoms and executive functioning: a population-based pediatric neuroimaging study.

Sabine E Mous, Tonya White, Ryan L Muetzel, Hanan El Marroun, Jolien Rijlaarsdam, Tinca J C Polderman, Vincent W Jaddoe, Frank C Verhulst, Danielle Posthuma, Henning Tiemeier

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PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of psychiatry & neuroscience : JPN, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Sabine E MousFrom the The Generation R Study Group, Erasmus MC, Rotterdam, The Netherlands (Mous, Muetzel, El Marroun, Jaddoe); the Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC-Sophia, Rotterdam, The Netherlands (Mous, White, Muetzel, El Marroun, Verhulst, Posthuma, Tiemeier); the Department of Radiology, Erasmus MC, Rotterdam, The Netherlands (White); the Centre for Child and Family Studies, Leiden University, Leiden, The Netherlands (Rijlaarsdam); the Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research (CNCR), VU University, Amsterdam, The Netherlands (Polderman, Posthuma); the Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands (Jaddoe, Tiemeier); the Department of Pediatrics, Erasmus MC-Sophia, Rotterdam, The Netherlands (Jaddoe); the Department of Clinical Genetics, VU MC, Amsterdam, The Netherlands (Posthuma); and the Department of Psychiatry, Erasmus MC, Rotterdam,The Netherlands (Tiemeier).
Tonya WhiteFrom the The Generation R Study Group, Erasmus MC, Rotterdam, The Netherlands (Mous, Muetzel, El Marroun, Jaddoe); the Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC-Sophia, Rotterdam, The Netherlands (Mous, White, Muetzel, El Marroun, Verhulst, Posthuma, Tiemeier); the Department of Radiology, Erasmus MC, Rotterdam, The Netherlands (White); the Centre for Child and Family Studies, Leiden University, Leiden, The Netherlands (Rijlaarsdam); the Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research (CNCR), VU University, Amsterdam, The Netherlands (Polderman, Posthuma); the Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands (Jaddoe, Tiemeier); the Department of Pediatrics, Erasmus MC-Sophia, Rotterdam, The Netherlands (Jaddoe); the Department of Clinical Genetics, VU MC, Amsterdam, The Netherlands (Posthuma); and the Department of Psychiatry, Erasmus MC, Rotterdam,The Netherlands (Tiemeier).
Ryan L MuetzelFrom the The Generation R Study Group, Erasmus MC, Rotterdam, The Netherlands (Mous, Muetzel, El Marroun, Jaddoe); the Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC-Sophia, Rotterdam, The Netherlands (Mous, White, Muetzel, El Marroun, Verhulst, Posthuma, Tiemeier); the Department of Radiology, Erasmus MC, Rotterdam, The Netherlands (White); the Centre for Child and Family Studies, Leiden University, Leiden, The Netherlands (Rijlaarsdam); the Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research (CNCR), VU University, Amsterdam, The Netherlands (Polderman, Posthuma); the Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands (Jaddoe, Tiemeier); the Department of Pediatrics, Erasmus MC-Sophia, Rotterdam, The Netherlands (Jaddoe); the Department of Clinical Genetics, VU MC, Amsterdam, The Netherlands (Posthuma); and the Department of Psychiatry, Erasmus MC, Rotterdam,The Netherlands (Tiemeier).
Hanan El MarrounFrom the The Generation R Study Group, Erasmus MC, Rotterdam, The Netherlands (Mous, Muetzel, El Marroun, Jaddoe); the Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC-Sophia, Rotterdam, The Netherlands (Mous, White, Muetzel, El Marroun, Verhulst, Posthuma, Tiemeier); the Department of Radiology, Erasmus MC, Rotterdam, The Netherlands (White); the Centre for Child and Family Studies, Leiden University, Leiden, The Netherlands (Rijlaarsdam); the Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research (CNCR), VU University, Amsterdam, The Netherlands (Polderman, Posthuma); the Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands (Jaddoe, Tiemeier); the Department of Pediatrics, Erasmus MC-Sophia, Rotterdam, The Netherlands (Jaddoe); the Department of Clinical Genetics, VU MC, Amsterdam, The Netherlands (Posthuma); and the Department of Psychiatry, Erasmus MC, Rotterdam,The Netherlands (Tiemeier).
Jolien RijlaarsdamFrom the The Generation R Study Group, Erasmus MC, Rotterdam, The Netherlands (Mous, Muetzel, El Marroun, Jaddoe); the Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC-Sophia, Rotterdam, The Netherlands (Mous, White, Muetzel, El Marroun, Verhulst, Posthuma, Tiemeier); the Department of Radiology, Erasmus MC, Rotterdam, The Netherlands (White); the Centre for Child and Family Studies, Leiden University, Leiden, The Netherlands (Rijlaarsdam); the Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research (CNCR), VU University, Amsterdam, The Netherlands (Polderman, Posthuma); the Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands (Jaddoe, Tiemeier); the Department of Pediatrics, Erasmus MC-Sophia, Rotterdam, The Netherlands (Jaddoe); the Department of Clinical Genetics, VU MC, Amsterdam, The Netherlands (Posthuma); and the Department of Psychiatry, Erasmus MC, Rotterdam,The Netherlands (Tiemeier).
Tinca J C PoldermanFrom the The Generation R Study Group, Erasmus MC, Rotterdam, The Netherlands (Mous, Muetzel, El Marroun, Jaddoe); the Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC-Sophia, Rotterdam, The Netherlands (Mous, White, Muetzel, El Marroun, Verhulst, Posthuma, Tiemeier); the Department of Radiology, Erasmus MC, Rotterdam, The Netherlands (White); the Centre for Child and Family Studies, Leiden University, Leiden, The Netherlands (Rijlaarsdam); the Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research (CNCR), VU University, Amsterdam, The Netherlands (Polderman, Posthuma); the Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands (Jaddoe, Tiemeier); the Department of Pediatrics, Erasmus MC-Sophia, Rotterdam, The Netherlands (Jaddoe); the Department of Clinical Genetics, VU MC, Amsterdam, The Netherlands (Posthuma); and the Department of Psychiatry, Erasmus MC, Rotterdam,The Netherlands (Tiemeier).
Vincent W JaddoeFrom the The Generation R Study Group, Erasmus MC, Rotterdam, The Netherlands (Mous, Muetzel, El Marroun, Jaddoe); the Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC-Sophia, Rotterdam, The Netherlands (Mous, White, Muetzel, El Marroun, Verhulst, Posthuma, Tiemeier); the Department of Radiology, Erasmus MC, Rotterdam, The Netherlands (White); the Centre for Child and Family Studies, Leiden University, Leiden, The Netherlands (Rijlaarsdam); the Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research (CNCR), VU University, Amsterdam, The Netherlands (Polderman, Posthuma); the Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands (Jaddoe, Tiemeier); the Department of Pediatrics, Erasmus MC-Sophia, Rotterdam, The Netherlands (Jaddoe); the Department of Clinical Genetics, VU MC, Amsterdam, The Netherlands (Posthuma); and the Department of Psychiatry, Erasmus MC, Rotterdam,The Netherlands (Tiemeier).
Frank C VerhulstFrom the The Generation R Study Group, Erasmus MC, Rotterdam, The Netherlands (Mous, Muetzel, El Marroun, Jaddoe); the Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC-Sophia, Rotterdam, The Netherlands (Mous, White, Muetzel, El Marroun, Verhulst, Posthuma, Tiemeier); the Department of Radiology, Erasmus MC, Rotterdam, The Netherlands (White); the Centre for Child and Family Studies, Leiden University, Leiden, The Netherlands (Rijlaarsdam); the Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research (CNCR), VU University, Amsterdam, The Netherlands (Polderman, Posthuma); the Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands (Jaddoe, Tiemeier); the Department of Pediatrics, Erasmus MC-Sophia, Rotterdam, The Netherlands (Jaddoe); the Department of Clinical Genetics, VU MC, Amsterdam, The Netherlands (Posthuma); and the Department of Psychiatry, Erasmus MC, Rotterdam,The Netherlands (Tiemeier).
Danielle PosthumaFrom the The Generation R Study Group, Erasmus MC, Rotterdam, The Netherlands (Mous, Muetzel, El Marroun, Jaddoe); the Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC-Sophia, Rotterdam, The Netherlands (Mous, White, Muetzel, El Marroun, Verhulst, Posthuma, Tiemeier); the Department of Radiology, Erasmus MC, Rotterdam, The Netherlands (White); the Centre for Child and Family Studies, Leiden University, Leiden, The Netherlands (Rijlaarsdam); the Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research (CNCR), VU University, Amsterdam, The Netherlands (Polderman, Posthuma); the Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands (Jaddoe, Tiemeier); the Department of Pediatrics, Erasmus MC-Sophia, Rotterdam, The Netherlands (Jaddoe); the Department of Clinical Genetics, VU MC, Amsterdam, The Netherlands (Posthuma); and the Department of Psychiatry, Erasmus MC, Rotterdam,The Netherlands (Tiemeier).
Henning TiemeierFrom the The Generation R Study Group, Erasmus MC, Rotterdam, The Netherlands (Mous, Muetzel, El Marroun, Jaddoe); the Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC-Sophia, Rotterdam, The Netherlands (Mous, White, Muetzel, El Marroun, Verhulst, Posthuma, Tiemeier); the Department of Radiology, Erasmus MC, Rotterdam, The Netherlands (White); the Centre for Child and Family Studies, Leiden University, Leiden, The Netherlands (Rijlaarsdam); the Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research (CNCR), VU University, Amsterdam, The Netherlands (Polderman, Posthuma); the Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands (Jaddoe, Tiemeier); the Department of Pediatrics, Erasmus MC-Sophia, Rotterdam, The Netherlands (Jaddoe); the Department of Clinical Genetics, VU MC, Amsterdam, The Netherlands (Posthuma); and the Department of Psychiatry, Erasmus MC, Rotterdam,The Netherlands (Tiemeier).
Erasmus University Rotterdam · NLErasmus MC · NLLeiden University · NLErasmus MC - Sophia Children’s Hospital · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAttention-deficit/hyperactivity symptoms have repeatedly been associated with poor cognitive functioning. Genetic studies have demonstrated a shared etiology of attention-deficit/hyperactivity disorder (ADHD) and cognitive ability, suggesting a common underlying neurobiology of ADHD and cognition. Further, neuroimaging studies suggest that altered cortical development is related to ADHD. In a large population-based sample we investigated whether cortical morphology, as a potential neurobiological substrate, underlies the association between attention-deficit/hyperactivity symptoms and cognitive problems.

methodsThe sample consisted of school-aged children with data on attention-deficit/hyperactivity symptoms, cognitive functioning and structural imaging. First, we investigated the association between attention-deficit/ hyperactivity symptoms and different domains of cognition. Next, we identified cortical correlates of attention-deficit/hyperactivity symptoms and related cognitive domains. Finally, we studied the role of cortical thickness and gyrification in the behaviour-cognition associations.

resultsWe included 776 children in our analyses. We found that attention-deficit/hyperactivity symptoms were associated specifically with problems in attention and executive functioning (EF; b = -0.041, 95% confidence interval [CI] -0.07 to -0.01, LIMITATIONS: The nature of our study did not allow us to draw inferences regarding temporal associations; longitudinal studies are needed for clarification.

conclusionIn a large, population-based sample of children, we identified a shared cortical morphology underlying attention-deficit/hyperactivity symptoms and EF.

Indexed as

Executive FunctionAttentionAttention Deficit Disorder with HyperactivityBrainChildCognitionCohort StudiesFemaleHumansMaleNeuroimagingNeuropsychological TestsOrgan SizeRegression AnalysisSex Characteristics

Identifiers

PMID27673503
PMCPMC5373699
OpenAlexW2548343009

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.