ReviewPediatric research2017
Fifty years of brain imaging in neonatal encephalopathy following perinatal asphyxia.
Review in Pediatric research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 2 syntheses or guidelines pooled it, 101 citations in OpenAlex.
- Brain proton magnetic resonance spectroscopy and neurodevelopment after preterm birth: a systematic review.Pediatric research · 2022Pooled it
- Magnetic Resonance Spectroscopy in Depressed Subjects Treated With Electroconvulsive Therapy-A Systematic Review of Literature.Frontiers in psychiatry · 2021Pooled it
- Early Determination of Prognosis in Neonatal Moderate or Severe Hypoxic-Ischemic Encephalopathy.Pediatrics · 2021Trial
- [Application of magnetic resonance imaging-compatible incubator in cranial magnetic resonance imaging for neonates: a multicenter prospective randomized clinical trial].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2020Trial
- Brain temperature of infants with neonatal encephalopathy following perinatal asphyxia calculated using magnetic resonance spectroscopy.Pediatric research · 2020Trial
- MRI and proton MR spectroscopy in neonatal hypoxic-ischemic encephalopathy: a comprehensive imaging review.Japanese journal of radiology · 2026Review
- Magnetic Resonance Imaging of the Neonatal Brain: Modalities, Scoring Systems, and Clinical Applications.Bioengineering (Basel, Switzerland) · 2026Review
- Microvascular ultrasound imaging of the neonatal brain: a scoping review.European journal of pediatrics · 2026Article
- Magnetic resonance imaging and spectroscopy in neonatal encephalopathy: current consensus position and future opportunities.Pediatric research · 2026Review
- Neuroprognostication in neonatal encephalopathy due to presumed hypoxic-ischemic encephalopathy.Pediatric research · 2025Review
- Does the Maternal Gut Microbiome Influence the Outcome of Perinatal Asphyxia?Antioxidants (Basel, Switzerland) · 2025Review
- Neonatal encephalopathy due to suspected hypoxic-ischaemic encephalopathy.World journal of pediatrics : WJP · 2025Article
- Paediatric cranial ultrasound: abnormalities of the brain in term neonates and young infants.Insights into imaging · 2025Article
- Current Knowledge of Neonatal Birth Asphyxia - a Review of Recent Literature and Novel Approach.Maedica · 2025Review
- Prediction of underweight, short stature, and microcephaly based on brain diffusion-weighted imaging sequence in neonates with stage.2 of hypoxic-ischemic encephalopathy: A follow-up study.International journal of reproductive biomedicine · 2024Article
- Magnetic Resonance Spectroscopy of Brain Metabolism in Fetuses With Congenital Heart Disease.Journal of the American College of Cardiology · 2023Observational
- Longitudinal perturbations of plasma nuclear magnetic resonance profiles in neonatal encephalopathy.Pediatric research · 2023Article
- Conflicting findings on the effectiveness of hydrogen therapy for ameliorating vascular leakage in a 5-day post hypoxic-ischemic survival piglet model.Scientific reports · 2023Article
- 3D doppler ultrasound imaging of cerebral blood flow for assessment of neonatal hypoxic-ischemic brain injury in mice.PloS one · 2023Article
- Value of cranial ultrasound at initiation of therapeutic hypothermia for neonatal encephalopathy.Journal of perinatology : official journal of the California Perinatal Association · 2022Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the past brain imaging of term infants with hypoxic-ischemic encephalopathy (HIE) was performed with cranial ultrasound (cUS) and computed tomography (CT). Both techniques have several disadvantages sensitivity and specificity is limited compared with magnetic resonance imaging (MRI) and CT makes use of radiation. At present MRI including diffusion weighted MRI during the first week of life, has become the method of choice for imaging infants with HIE. In addition to imaging, blood vessels and blood flow can be visualized using MR angiography, MR venography, and arterial spin labeling. Since the use of these techniques additional lesions in infants with HIE, such as arterial ischemic stroke, sinovenous thrombosis, and subdural hemorrhages can be diagnosed, and the incidence appears to be higher than shown previously. Phosphorus magnetic resonance spectroscopy (MRS) has led to the concept of secondary energy failure in infants with HIE, but has not been widely used. Proton MRS of the basal ganglia and thalamus is one of the best predictors of neurodevelopmental outcome. cUS should still be used for screening infants admitted to a NICU with neonatal encephalopathy. In the future magnetic resonance techniques will be increasingly used as early biomarkers of neurodevelopmental outcome in trials of neuroprotective strategies.
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Registered trials
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