Evidence map›Paper›PMID 27673421›Full record

ReviewPediatric research2017

Does prenatal stress alter the developing connectome?

Dustin Scheinost, Rajita Sinha, Sarah N Cross, Soo Hyun Kwon, Gordon Sze, R Todd Constable, Laura R Ment

Abstract readReview
In one paragraph

Review in Pediatric research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers.

0numbers the graph read from it
0cells of the map it votes in
79citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

79 citing papers in PubMed.

  1. Trial
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  8. Early-life neural correlates of behavioral inhibition and anxiety risk.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Review
  9. Article
  10. Article
  11. Review
  12. Article
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  14. Review
  15. Article
  16. The adaptive stochasticity hypothesis: Modeling equifinality, multifinality, and adaptation to adversity.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  17. Article
  18. The patient/physician relationship in a post-Roe world: a neonatologist viewpoint.Journal of perinatology : official journal of the California Perinatal Association · 2023
    Review
  19. Review
  20. Article

19 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Dustin ScheinostDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut.
Rajita SinhaDepartment of Psychiatry, Yale School of Medicine, New Haven, Connecticut.
Sarah N CrossDepartment of Obstetrics, Gynecology, and Reproductive Sciences, Yale School of Medicine, New Haven, Connecticut.
Soo Hyun KwonDepartment of Pediatrics, Yale School of Medicine, New Haven, Connecticut.
Gordon SzeDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut.
R Todd ConstableDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut.
Laura R MentDepartment of Pediatrics, Yale School of Medicine, New Haven, Connecticut.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
NCATS NIH HHS UL1 TR001863
6 · The paper itself

Abstract

Human neurodevelopment requires the organization of neural elements into complex structural and functional networks called the connectome. Emerging data suggest that prenatal exposure to maternal stress plays a role in the wiring, or miswiring, of the developing connectome. Stress-related symptoms are common in women during pregnancy and are risk factors for neurobehavioral disorders ranging from autism spectrum disorder, attention deficit hyperactivity disorder, and addiction, to major depression and schizophrenia. This review focuses on structural and functional connectivity imaging to assess the impact of changes in women's stress-based physiology on the dynamic development of the human connectome in the fetal brain.

Indexed as

ConnectomePregnancy ComplicationsStress, PsychologicalAnxietyAttention Deficit Disorder with HyperactivityAutism Spectrum DisorderBrainFemaleFetal DiseasesHumansMagnetic Resonance ImagingMajor Depressive DisorderMaleNerve NetNeural PathwaysPregnancy

Identifiers

PMID27673421
PMCPMC5313513

What OpenQuestion holds

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LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.